Results 211 to 220 of about 213,470 (338)

Intranasal Naloxone During Recurrent Exercise in Individuals with Type‐1 Diabetes Mellitus: Evaluation of the Clinical Predictors of Pharmacokinetics and Exposure–Response

The Journal of Clinical Pharmacology, EarlyView.
Abstract Impaired awareness of hypoglycemia (IAH) impacts 25%–30% of individuals with type 1 diabetes mellitus (T1D), potentially leading to severe outcomes due to reduced symptom perception. Naloxone, a mu‐opioid receptor antagonist, shows promise as a preventive measure against IAH.
Omar N. Al Yacoub, Shen Cheng, Mohamed S. Fayed, James Fisher, Jillian Brooks, Elizabeth Seaquist, Anjali Kumar, Amir Moheet, Lynn Eberly, Lisa D. Coles   +9 more
wiley   +1 more source

Utilization of Proteomic Measures for Early Detection of Drug Benefits and Adverse Effects

The Journal of Clinical Pharmacology, EarlyView.
Abstract Recognition of benefits and adverse effects of therapies in earlier clinical trial phases could improve the safety, efficiency, and cost of clinical trials. Using four clinical trials representing a diverse set of diseases and drug classes (EXSCEL: exenatide/GLP‐1 RA, SUGAR‐DM‐HF: empagliflozin/SGLT2i, PRADA: epirubicin/anthracycline, and ...
Jessica Chadwick, Colin Berry, Meredith A. Carpenter, Geeta Gulati, Siri Lagethon Heck, Michael A. Hinterberg, Rury R. Holman, Matthew M.Y. Lee, Torbjørn Omland, Clare Paterson, Mark C. Petrie, Naveed Sattar, Svati H. Shah, Sama Shrestha, Harald Sourij, Emma V Troth, Victoria Vinje, Stephen A. Williams   +17 more
wiley   +1 more source

Allosteric communication mechanism in the glucagon receptor. [PDF]

J Biol Chem
van der Velden WJC, Mukhaleva E, Vaidehi N.   +2 more
europepmc   +1 more source

Mortality and cardiovascular disease after cholecystectomy in type 2 diabetes: A nationwide longitudinal cohort study

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
Abstract Background The long‐term effects of cholecystectomy on mortality and cardiovascular disease (CVD) in patients with diabetes have not been evaluated. In the present study, we investigated the longitudinal effects of cholecystectomy on mortality and CVD in a population‐based cohort with type 2 diabetes (T2D). Methods In total, 2 216 930 national
Han Na Jung, Ji Hye Heo, Eun Roh, Kyung‐Do Han, Jun Goo Kang, Seong Jin Lee, Sung‐Hee Ihm   +6 more
wiley   +1 more source

GLP-1R in diabetes mellitus: from basic discovery to therapeutics development. [PDF]

Front Pharmacol
Li S, Huang N, Wang M, Huang W, Luo Y, Huang J.   +5 more
europepmc   +1 more source

Genetically‐targeted control of the spinal cord and peripheral nervous system

Journal of Intelligent Medicine, EarlyView.
Application of genetically‐targeted stimulation for treating diseases or injuries outside the brain. Optogenetic and chemogenetic systems have been developed for dysfunction in the cochlea, spinal cord, dorsal root ganglia (DRGs), peripheral nerves, lower urinary tract, and enteric nervous system (ENS). Created with Biorender.com.
Anakaren Romero Lozano, Victoria Koptelova, Zoya Ahmad, Huiliang (Evan) Wang   +3 more
wiley   +1 more source

Retatrutide-A Game Changer in Obesity Pharmacotherapy. [PDF]

Biomolecules
Katsi V, Koutsopoulos G, Fragoulis C, Dimitriadis K, Tsioufis K.   +4 more
europepmc   +1 more source

State‐of‐the‐art review of blenderized diets—Status and future directions

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract This state‐of‐the‐art review was produced by a multidisciplinary team composed of pediatric gastroenterology and nutrition healthcare providers to provide a comprehensive overview of the use of blenderized tube feeds (BTFs). The team developed 12 vital questions to address gaps in the current understanding and practice of using BTFs, then ...
Sharon Weston, Anushree Algotar, Sara Karjoo, Megan Gabel, Patrice Kruszewski, Debora Duro, Senthilkumar Sankararaman, Danielle Wendel, Shweta S. Namjoshi, Ruba A. Abdelhadi, David Kawatu, Mark R. Corkins, Timothy Sentongo   +12 more
wiley   +1 more source

Glucagon-like peptide-1 receptor agonists in neuropathic pain: hype or hope? [PDF]

Korean J Pain
Choi JI.
europepmc   +1 more source

ABILITY OF GLUCAGON TO PRODUCE CARDIAC STIMULATION WITHOUT ARRHYTHMIAS IN HALOTHANE-ANAESTHETIZED ANIMALS

, 1969
Ronald L. Katz, Llynda Hinds, C J Mills
openalex   +1 more source