Results 211 to 220 of about 140,006 (312)

Monogenic and syndromic obesity in children: Clinical recognition, genetics, and precision management

Pediatric Investigation, EarlyView.
Monogenic and syndromic obesity in children often arises from defects in the leptin–melanocortin pathway. Understanding these rare genetic causes not only clarifies mechanisms of appetite regulation but also enables precision therapies, offering hope beyond lifestyle interventions.
Hadel Khalil, Eugene Feigin, Hussein Zaitoon   +2 more
wiley   +1 more source

Glucagon-Like Peptide-1 Receptor Agonists Across the Heart Failure Spectrum: A Systematic Review and Meta-Analysis. [PDF]

Cureus
Muller Ferreira V, Ayres Muller V.
europepmc   +1 more source

Living Well With Type 1 Diabetes in Middle School: A Student‐Centered Perspective

Psychology in the Schools, EarlyView.
ABSTRACT Type 1 diabetes (T1D) is among the most common chronic illnesses affecting children and adolescents, meaning that all schools regularly include students with T1D. Supporting their well‐being requires understanding how they experience middle school to address their specific needs.
Isabelle Joing, Gaëlle Marais, Aurore Huchez, Elodie Lespagnol, Elsa Heyman   +4 more
wiley   +1 more source

Association of fasting plasma glucagon with osteopenia/osteoporosis in Chinese patients with type 2 diabetes. [PDF]

BMC Endocr Disord
Zhang L, Zhang P, Shi R.
europepmc   +1 more source

When Fat Goes Astray: Your Liver and Pancreas Get Into Trouble

Portal Hypertension &Cirrhosis, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) and intrapancreatic fat deposition (IPFD) are both common manifestations of ectopic fat accumulation. Although they share multiple risk factors, they also show notable differences in pathological features, standardization of diagnosis, and research maturity.
Yuying Chen, Li Ding, Shan Zhao, Weihong Wang, Jing Zhong, Qiang Yan   +5 more
wiley   +1 more source

CHD4 and NKX2.2 Cooperate to Regulate β-Cell Function by Repressing Non-β-Cell Gene Programs. [PDF]

Diabetes
Sarbaugh D, Oliveira TG, Guney MA, Casey MR, Hoelscher VM, Hill CJ, Michel CR, Wells KL, Benninger RKP, Sussel L.   +9 more
europepmc   +1 more source

From cytokine storm to renal scarring in diabetic kidney disease: Biomarkers, risk stratification, and precision therapeutics

Precision Medical Sciences, EarlyView.
Hyperglycemia‐driven cytokine activation initiates a sustained inflammatory cascade in diabetic kidney disease, promoting cellular injury and fibrogenic signaling. Integrating cytokine‐based biomarkers with risk stratification enables precision therapeutics that target inflammation and fibrosis, ultimately aiming to halt progression from early renal ...
Emmanuel Ifeanyi Obeagu
wiley   +1 more source

Glucagon promotes net hepatic glycogen repletion following meal ingestion. [PDF]

JCI Insight
Kejriwal N, Bouslov D, Castle CR, Karve RS, Arkharova GA, Sargsyan A, Drucker DJ, Zhang GF, D'Alessio DA, Campbell JE, Capozzi ME.   +10 more
europepmc   +1 more source

Impact of Stabilizing Osmolytes on the Conformational Dynamics of Human and Rat Islet Amyloid Polypeptides

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The aggregation of human islet amyloid polypeptide (hIAPP) into cytotoxic oligomers and amyloid fibrils is a hallmark of type 2 diabetes mellitus (T2DM), leading to pancreatic β‐cell dysfunction. In contrast, rat IAPP (rIAPP) is largely non‐amyloidogenic. Osmolytes such as glucose, glycerol, and sorbitol are known to stabilize globular protein
Kiara A. Kidman, Claudio Pedrick, Cara A. Kreck, Ricardo L. Mancera   +3 more
wiley   +1 more source

The expanding landscape of the glucagon signaling network: mechanisms and outcomes.

Endocrinology
Foollee A, Wu Y, Rusu PM, Rose AJ.
europepmc   +1 more source