Results 41 to 50 of about 114,692 (269)
Molecular Oncology, EarlyView.The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu +3 more
wiley +1 more source
eLife, 2016 The hormones insulin and glucagon both play important roles in the development of diabetes.
Lena Eliasson, Anna Wendt
doaj +1 more source
Alpha-cell paracrine signaling in the regulation of beta-cell insulin secretion
Frontiers in Endocrinology, 2022 As an incretin hormone, glucagon-like peptide 1 (GLP-1) lowers blood glucose levels by enhancing glucose-stimulated insulin secretion from pancreatic beta-cells.
Marlena M. Holter +3 more
doaj +1 more source
A Local Counter-Regulatory Motif Modulates the Global Phase of Hormonal Oscillations [PDF]
, 2016 Counter-regulatory elements maintain dynamic equilibrium ubiquitously in living systems. The most prominent example, which is critical to mammalian survival, is that of pancreatic {\alpha} and {\beta} cells producing glucagon and insulin for glucose homeostasis.
arxiv +1 more source
FEBS Open Bio, EarlyView.GPR142, a tryptophan‐sensing receptor, stimulates gastrointestinal hormones like ghrelin and is linked to inflammation regulation. Proinflammatory cytokines suppress ghrelin production, while tryptophan levels decrease via IDO1 activation. Our findings reveal that proinflammatory cytokines directly regulate GPR142 expression in ghrelin‐producing cells,
Yoko Ueda +15 more
wiley +1 more source
Frontiers in Physiology, 2019 BackgroundInterleukin-6 (IL-6) is released from skeletal muscle during exercise and systemic IL-6 levels therefore increase acutely in response to a single bout of exercise.
Louise Lang Lehrskov +22 more
doaj +1 more source
In vitro assessment of pancreatic hormone secretion from isolated porcine islets
Frontiers in Endocrinology, 2022 The potential use of porcine islets for transplantation in humans has triggered interest in understanding porcine islet physiology. However, the number of studies dedicated to this topic has remained limited, as most islet physiologists prefer to use the
Nizar I. Mourad +2 more
doaj +1 more source
Bayesian Analysis of Glucose Dynamics during the Oral Glucose Tolerance Test (OGTT) [PDF]
arXiv, 2020 In this paper, we propose a model of the dynamics of the blood glucose level during an Oral Glucose Tolerance Test (OGTT). This dynamic includes the action of insulin and glucagon in the glucose homeostasis process as the reaction of an oral stimulus.
arxiv
Beneficial effects of intercellular interactions between pancreatic islet cells in blood glucose regulation [PDF]
, 2009 Glucose homeostasis is controlled by the islets of Langerhans which are equipped with alpha-cells increasing the blood glucose level, beta-cells decreasing it, and delta-cells the precise role of which still needs identifying. Although intercellular communications between these endocrine cells have recently been observed, their roles in glucose ...
arxiv +1 more source
Liraglutide for idiopathic intracranial hypertension: a real‐world propensity score‐matched study
Annals of Clinical and Translational Neurology, EarlyView.Abstract Objective Idiopathic intracranial hypertension (IIH) is a neurological disorder predominantly affecting young women with obesity, characterized by elevated intracranial pressure. While current treatments include weight loss counseling, medical therapies, and surgical interventions, their limitations necessitate exploring novel therapeutic ...
Ahmed Y. Azzam +13 more
wiley +1 more source