Results 41 to 50 of about 125,192 (190)

A Facile Procedure for One-Pot Stable Conjugation of Two Proglucagon Cysteine-Containing Peptide Analogs

Frontiers in Endocrinology, 2021
Optimization of peptides for therapeutic purposes often includes chemical conjugation or modification with substituents that serve to broaden pharmacology or improve pharmacokinetics.
Rongjun He, Stephanie A. Mowery, Joseph Chabenne, Brian Finan, John P. Mayer, Richard D. DiMarchi   +5 more
doaj   +1 more source

Liver regeneration in dogs: Morphologic and chemical changes [PDF]

, 1978
Forty-four percent and 72% hepatectomy were carried out in dogs and the animals were sacrificed for biochemical and pathologic studies from 0.5 to 6 days later.
Antonio Francavilla, Arthur F. Jones, Bucher, Bucher, Burton, Duguay, Faloona, Farivar, Fisher, Giles, Grisham, Harper, Herbert, Holley, Joseph Benichou, Kendrick A. Porter, Krishna, Leffert, Leffert, Loud, Lowry, MacManus, Makman, Moody, Price, Salomon, Schneider, Short, Starzl, Starzl, Starzl, Thomas E. Starzl, Weinbren, White, Whittemore   +34 more
core   +1 more source

Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1 diabetes

eLife, 2021
Insulin-induced hypoglycemia is a major treatment barrier in type-1 diabetes (T1D). Accordingly, it is important that we understand the mechanisms regulating the circulating levels of glucagon.
Angela Kim, Jakob G Knudsen, Joseph C Madara, Anna Benrick, Thomas G Hill, Lina Abdul Kadir, Joely A Kellard, Lisa Mellander, Caroline Miranda, Haopeng Lin, Timothy James, Kinga Suba, Aliya F Spigelman, Yanling Wu, Patrick E MacDonald, Ingrid Wernstedt Asterholm, Tore Magnussen, Mikkel Christensen, Tina Vilsbøll, Victoria Salem, Filip K Knop, Patrik Rorsman, Bradford B Lowell, Linford JB Briant   +23 more
doaj   +1 more source

The origin, hormonal nature, and action of hepatotrophic substances in portal venous blood [PDF]

, 1973
The hepatotrophic factors previously reported to be in splanchnic venous blood are pancreatic hormones and specifically insulin and glucagon. Of these, insulin is anabolic and glucagon is mainly catabolic but not exclusively so, since glucagon also has ...
Brown, TH, Francavilla, A, Francavilla, FR, Halgrimson, CG, Porter, KA, Putnam, CW, Starzl, TE   +6 more
core  

Evidence that host size determines liver size: Studies in dogs receiving orthotopic liver transplants [PDF]

, 1987
Orthotopic liver transplantation was performed in two groups of dogs; Group I animals consisted of large dogs that served as recipients of livers obtained from smaller dogs while Group II animals consisted of dogs that received liver from donor dogs of ...
Bucher, Bucher, Kahn, Koch, Leffert, Leffert, Leffert, McGowan, Morley, Putman, Richman, Rubin, Russell, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Strecker, Van Thiel, Van Thiel, Wagle   +28 more
core   +1 more source

Partners for life

eLife, 2016
The hormones insulin and glucagon both play important roles in the development of diabetes.
Lena Eliasson, Anna Wendt
doaj   +1 more source

Alpha-cell paracrine signaling in the regulation of beta-cell insulin secretion

Frontiers in Endocrinology, 2022
As an incretin hormone, glucagon-like peptide 1 (GLP-1) lowers blood glucose levels by enhancing glucose-stimulated insulin secretion from pancreatic beta-cells.
Marlena M. Holter, Mridusmita Saikia, Mridusmita Saikia, Bethany P. Cummings   +3 more
doaj   +1 more source

Effects of Exercise Training and IL-6 Receptor Blockade on Gastric Emptying and GLP-1 Secretion in Obese Humans: Secondary Analyses From a Double Blind Randomized Clinical Trial

Frontiers in Physiology, 2019
BackgroundInterleukin-6 (IL-6) is released from skeletal muscle during exercise and systemic IL-6 levels therefore increase acutely in response to a single bout of exercise.
Louise Lang Lehrskov, Regitse Højgaard Christensen, Anne-Sophie Wedell-Neergaard, Grit Elster Legaard, Emma Dorph, Monica Korsager Larsen, Marie Henneberg, Natja Launbo, Sabrina Ravn Fagerlind, Sidsel Kofoed Seide, Stine Nymand, Maria Ball, Nicole Vinum, Camilla Dahl, Nicolai Jacob Wewer Albrechtsen, Nicolai Jacob Wewer Albrechtsen, Jens Juul Holst, Mathias Ried-Larsen, Jaya Birgitte Rosenmeier, Rikke Krogh-Madsen, Kristian Karstoft, Bente Klarlund Pedersen, Helga Ellingsgaard   +22 more
doaj   +1 more source

In vitro assessment of pancreatic hormone secretion from isolated porcine islets

Frontiers in Endocrinology, 2022
The potential use of porcine islets for transplantation in humans has triggered interest in understanding porcine islet physiology. However, the number of studies dedicated to this topic has remained limited, as most islet physiologists prefer to use the
Nizar I. Mourad, Daela Xhema, Pierre Gianello   +2 more
doaj   +1 more source

Metabolic and hormonal studies of Type 1 (insulin-dependent) diabetic patients after successful pancreas and kidney transplantation [PDF]

, 1991
Long-term normalization of glucose metabolism is necessary to prevent or ameliorate diabetic complications. Although pancreatic grafting is able to restore normal blood glucose and glycated haemoglobin, the degree of normalization of the deranged ...
AD Baron, B Glaser, D. Abendroth, DER Sutherland, E Bosi, F. Fiedler, G Tyd�n, GB Bolli, GC Weir, GK Stalla, J Nusser, J �stman, J. Nusser, JD Peuler, K Osei, K Werder v, KF Hanssen, L Luzi, LG Heding, P Diem, P Diem, PG Passon, R Landgraf, R. L. Riepl, R. Landgraf, RJ Jarrett, RL Riepl, RP Eaton, SA Amiel, TW Schwartz, W Land, W Land, W. -D. Illner, W. Land   +33 more
core   +2 more sources