Results 111 to 120 of about 460,157 (392)

Synthesis of budesonide conjugates and their anti-inflammatory effects: a preliminary study

Drug Design, Development and Therapy, 2019
Yan Yan,1,2 Pengchong Wang,2 Ruiying Li,3 Ying Sun,2 Rui Zhang,2 Chuanchuan Huo,2 Jianfeng Xing,2 Yalin Dong1 1Department of Pharmacy, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China; 2Department of ...
Yan Y, Wang P, Li R, Sun Y, Zhang R, Huo C, Xing J, Dong Y   +7 more
doaj  

Behavioral neuroadaptation to alcohol : from glucocorticoids to histone acetylation

Frontiers in Psychiatry, 2016
A prime mechanism that contributes to the development and maintenance of alcoholism is the dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis activity and the release of glucocorticoids (cortisol in humans and primates, corticosterone in ...
Daniel Beracochea, Nicole Mons
doaj   +1 more source

Effects of intrauterine exposure to synthetic glucocorticoids on fetal, newborn, and infant hypothalamic-pituitary-adrenal axis function in humans : a systematic review [PDF]

, 2009
BACKGROUND: Synthetic glucocorticoids are commonly used in reproductive medicine. Fetal organ systems are highly sensitive to changes in the intrauterine environment, including overexposure to glucocorticoids.
1994 Effect of corticosteroids for fetal maturation on perinatal outcomes, Alkalay, Anderson, Andrews, Arlt, Arnold, Asa, Ashwood, Audus, Baker, Ballabh, Ballard, Ballard, Bamberger, Banks, Banks, Barbazanges, Battin, Baulieu, Benassayag, Benediktsson, Bertram, Bettendorf, Blanford, Blettner, Blumenfeld, Bolt, Bolt, Bradley, Bresson, Brosnan, Brown, Burlet, Buske-Kirschbaum, Buske-Kirschbaum, Buske-Kirschbaum, Buske-Kirschbaum, Buttgereit, Carroll, Cattarelli, Charmandari, Christopher Pryce, Chrousos, Cintra, Clifton, Cole, Condon, Crowley, Crowley, Cummings, Czock, Dalziel, Davis, Davis, Dawes, De Kloet, De Kloet, de Kloet, De Kloet, de Kloet, de Weerth, Dean, Dean, Diederich, Diego, Dobbing, Doyle, Dörr, Dörr, Dwan, Easterbrook, Ebrecht, Felszeghy, Fiad, Ford, French, French, Fries, Gatelais, Gayrard, Gennser, Giannakoulopoulos, Giannakoulopoulos, Gibbs, Gitau, Gitau, Glover, Goland, Grier, Grossmann, Gunther Meinlschmidt, Gutteling, Haley, Hanna, Hauser, Haussmann, Heckmann, Heim, Herman, Hingre, Holsboer, Högger, Ioannidis, Jahnukainen, Jaquier, Jeffray, Jobe, Jüni, Kairalla, Kajantie, Kajantie, Kalabis, Kalabis, Kamphuis, Kanitz, Kapoor, Kapoor, Karemaker, Kari, Karlsson, Karssen, Kauppila, Kavelaars, Keene, Kirschbaum, Klemcke, Kononen, Korte, Krauer, Lee, Lee, Lee, Levine, Levitt, Liggins, Liggins, Lindh, Lindsay, Little, Loebstein, MacArthur, Macnaughton, Manabe, Marinoni, Marion Tegethoff, Mark, Mark, Matthews, McAlister, Meadow, Mears, Meijer, Melby, Mesiano, Miller, Modi, Moss, Muneoka, Murphy, Murphy, Murphy, Murphy, National Institutes of Health Consensus Development Panel, Nelson, Nelson, Ng, Ng, Ng, Ng, Ng, Ng, Ng, Noguchi, Nomura, Noorlander, Nordenström, Nykänen, O'Regan, O'Shea, Oelkers, Ohrlander, Ohrlander, Oken, Olufemi, Osathanondh, Owen, Ozawa, Pacheco, Paddock, Parker Jr, Parker Jr, Patel, Peets, Pepe, Pepe, Petersen, Petersen, Petraglia, Petropoulos, Phillips, Pryce, Pryce, Reichardt, Reis, Rizvi, Roberts, Rocci Jr, Rosati, Samtani, Sandesh Kiran, Sapolsky, Sánchez, Schatz, Schwab, Schwab, Seckl, Seckl, Seckl, Serón-Ferré, Shulman, Sippell, Sloboda, Speirs, Speiser, Stein, Streeten, Stroup, Sucheston, Sun, Sybulski, Szabó, Taylor, Tenhola, Teramo, Terrone, Terrone, Thliveris, Trestman, Tsigos, Uhr, Uno, van der Heide-Jalving, Van Hoof, van Runnard Heimel, van Runnard Heimel, Veldhuis, Veldhuis, Vogl, Walters, Watterberg, Welberg, White, Whittaker, Wilson, Wittekind, Yates, Yeh, Yeh   +257 more
core   +2 more sources

Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy

Advanced Therapeutics, EarlyView.
This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar, Weiwei Guo, Xin Shen, Yimeng Fang, Yilin Liu, Peng‐Yuan Wang, Roey Elnathan, Yaping Chen   +7 more
wiley   +1 more source

Maternal-Fetal Circadian Communication During Pregnancy

Frontiers in Endocrinology, 2020
This article reviews evidence for maternal-fetal communication about the time of day. We explore the hypothesis that key maternal hormones synchronize daily rhythms in the fetus to regulate gestation duration.
Keenan Bates, Erik D. Herzog
doaj   +1 more source

The glucocorticoid receptor in inflammatory processes : transrepression is not enough [PDF]

, 2015
Glucocorticoids (GCs) are the most commonly used anti-inflammatory agents to treat inflammatory and immune diseases. However, steroid therapies are accompanied by severe side-effects during long-term treatment. The dogma that transrepression of genes, by
Dejager, Lien, Hübner, Sabine, Libert, Claude, Tuckermann, Jan P   +3 more
core   +2 more sources

Viral‐Mediated Connexin 26 Expression Combined with Dexamethasone Rescues Hearing in a Conditional Gjb2 Null Mice Model

Advanced Science, EarlyView.
AAV2.7m8 serotype combined with the gfaABC1D promoter targets infection of supporting cells (SCs). AAV2.7m8‐gfaABC1D‐Gjb2 administration to mice results in excessive immune responses. The combination of AAV2.7m8‐gfaABC1D‐Gjb2 with dexamethasone (DEX) shows a synergistic effect and enhances the gene therapy effect in a conditional Cx26 null mice model ...
Xiaohui Wang, Li Zhang, Sen Chen, Le Xie, Yue Qiu, Chenyang Kong, Ge Yin, Weijia Kong, Yu Sun   +8 more
wiley   +1 more source

The role of brain-derived neurotrophic factor (BDNF) in comorbid depression: possible linkage with steroid hormones, cytokines, and nutrition

Frontiers in Psychiatry, 2014
Increasing evidence demonstrates a connection between growth factor function (including brain-derived neurotrophic factor, BDNF), glucocorticoid levels (one of the steroid hormones), and the pathophysiology of depressive disorders.
Tadahiro eNumakawa, Misty eRichards, Shingo eNakajima, Naoki eAdachi, Miyako eFuruta, Haruki eOdaka, Hiroshi eKunugi   +6 more
doaj   +1 more source

MicroRNA-433 Dampens Glucocorticoid Receptor Signaling, Impacting Circadian Rhythm and Osteoblastic Gene Expression [PDF]

, 2016
FUNDING This work was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health [AR44877]; the National Institutes for Dental and Craniofacial Research [5T90DE21989]; a Grant-in-Aid award ...
Delany, Anne M, Dole, Neha S, Franceschetti, Tiziana, Hrdlicka, Henry C, Smith, Spenser S   +4 more
core   +1 more source

Colonic Submucosa Targeted Delivery of Probiotic and Rhein for Ulcerative Colitis Treatment

Advanced Science, EarlyView.
A novel orally drug‐probiotic co‐delivery system designated as Rh‐YBS for UC treatment, which highlights three innovations: (i) YPs involves colonic submucosa delivery via M cells; (ii) Rh (drug) promotes the colonization and growth of BS (probiotic) in the colon.
Lingqiang Li, Linxin Dai, Meisi Lin, Shuang He, Hongye Du, Dasheng Lin, Yanbin Wang, Fenglian Zhang, Sian Tao, Xiaoluo Sun, Xinggui Huang, Haihui Liu, Qian Wang, Lingling He, Kunhe Wu, Jieshu You, Minyue Zhang, Chaomei Fu, He Tu, Naijing Ye, Jibin Liu, Fei Gao   +21 more
wiley   +1 more source