Results 181 to 190 of about 443,164 (406)

The thioredoxin system: Balancing redox responses in immune cells and tumors

European Journal of Immunology, Volume 53, Issue 1, January 2023., 2023
The thioredoxin (TRX) system is a critical contributor to cellular redox homeostasis in all living cells. Here, we review the key roles of TRX for activation, proliferation, and responses in T cells, B cells, and myeloid cells. Further, we conceptualize how this knowledge may be therapeutically exploited for cancer treatment.
Jonathan Muri, Manfred Kopf
wiley   +1 more source

Glucocorticoid Suppression of Urinary Testosterone Excretion in Patients with Idiopathic Hirsutism [PDF]

, 1966
Thomas E. Nichols, Charles A. Nugent, Frank H. Tyler   +2 more
openalex   +1 more source

SGK1 in the kidney: disrupted sodium transport in diabetes and beyond [PDF]

, 2009
Renal complications of diabetes can be severe; however, the mechanisms that underlie the development and progression of diabetic nephropathy are poorly understood.
Bland, Rosemary, Hills, Claire E., Squires, Paul E.   +2 more
core  

Comparative Analysis of Pre-trained Deep Learning Models and DINOv2 for Cushing's Syndrome Diagnosis in Facial Analysis [PDF]

arXiv
Cushing's syndrome is a condition caused by excessive glucocorticoid secretion from the adrenal cortex, often manifesting with moon facies and plethora, making facial data crucial for diagnosis. Previous studies have used pre-trained convolutional neural networks (CNNs) for diagnosing Cushing's syndrome using frontal facial images.
arxiv  

Atherosclerotic Plaque Progression and Incident Cardiovascular Events in a 10‐Year Prospective Study of Patients With Systemic Lupus Erythematosus: The Impact of Persistent Cardiovascular Risk Factor Target Attainment and Sustained DORIS Remission

Arthritis &Rheumatology, EarlyView.
Objective Cardiovascular disease (CVD) is a leading cause of death in individuals with systemic lupus erythematosus (SLE). We assessed atherosclerotic plaque progression and incident cardiovascular events in patients with SLE over a 10‐year follow‐up.
Nikolaos Papazoglou, Petros P. Sfikakis, Maria G. Tektonidou   +2 more
wiley   +1 more source

Pleural CD14+ monocytes/macrophages of healthy adolescents show a high expression of metallothionein family genes

European Journal of Immunology, Volume 53, Issue 1, January 2023., 2023
Modern surgical (technical) possibilities enable pleural macrophage isolation and analyses regardless the person`s age. Transcriptome profiling of macrophages from healthy or sick individuals revealed that these cells express high levels of metallothioneins, metal‐binding proteins that are involved in heavy metal detoxification, antioxidative defense ...
Nagoud Schukfeh, Bin Liu, David S. DeLuca, Srinu Tumpara, Christoph Nikolin, Stephan Immenschuh, Benno M. Ure, Joachim F. Kuebler, Tobias Welte, Dorothee Viemann, Sabina M. Janciauskiene, Gertrud Vieten   +11 more
wiley   +1 more source

An Immunosenescent CD8+ T Cell Subset in Patients with Axial Spondyloarthritis and Psoriatic Arthritis Links Spontaneous Motility to Telomere Shortening and Dysfunction

Arthritis &Rheumatology, EarlyView.
Objective A pathogenetic role of CD8+ T lymphocytes in radiographic axial spondyloarthritis (r‐axSpA) and other spondyloarthritis (SpA) is sustained by genome‐wide association studies and by the expansion of public T cell clonotypes in the target tissues.
Giorgia Paldino, Valentina Tedeschi, Valentina Proganò, Erica Salvati, Valerio Licursi, Eleonora Vertecchi, Alexandru L. Bivolaru, Emanuele Molteni, Rossana Scrivo, Mattia Congia, Alberto Cauli, Rosalba Caccavale, Marino Paroli, Martina Kunkl, Loretta Tuosto, Rosa Sorrentino, Maria Teresa Fiorillo   +16 more
wiley   +1 more source

Effects of altered salt intake and diet on cytokines in humans: A 20‐week randomized cross‐over intervention study

European Journal of Immunology, Volume 53, Issue 1, January 2023., 2023
The effect of habitual Western diet and salt‐reduced diet on the levels of systemic blood cytokines was analyzed in a placebo‐controlled nutritional intervention study. The results showed that reduced salt intake did not alter the concentrations of any of the analyzed 34 cytokines in blood.
Teemu Niiranen, Iris Erlund, Sirpa Jalkanen, Antti Jula, Marko Salmi   +4 more
wiley   +1 more source

Tumor dissemination in cancer patients treated with acth, glucocorticoid, and oxidated nitrogen mustard [PDF]

, 1963
J Arraztoa, Julián Rodrı́guez, Luis Vargas   +2 more
openalex   +1 more source

Proteomic Profiling of the Large‐Vessel Vasculitis Spectrum Identifying Shared Signatures of Innate Immune Activation and Stromal Remodeling

Arthritis &Rheumatology, EarlyView.
Objective Takayasu arteritis (TAK) and giant cell arteritis (GCA), the most common forms of large‐vessel vasculitis (LVV), can result in serious morbidity. Understanding the molecular basis of LVV should aid in developing better biomarkers and treatments. Methods Plasma proteomic profiling of 184 proteins was performed in two cohorts. Cohort 1 included
Robert T. Maughan, Erin Macdonald‐Dunlop, Lubna Haroon‐Rashid, Louise Sorensen, Natalie Chaddock, Shauna Masters, Andrew Porter, Marta Peverelli, Charis Pericleous, Andrew Hutchings, James Robinson, Taryn Youngstein, Raashid A. Luqmani, Justin C. Mason, Ann W. Morgan, James E. Peters   +15 more
wiley   +1 more source