Results 181 to 190 of about 195,219 (266)

Asymmetric Synthesis and Biological Evaluation of 1,3‐ and 1,4‐Disubstituted Isoquinoline‐Containing Lipoxin A4 Analogues

Chemistry – A European Journal, EarlyView.
(1R)‐ and (1S)‐Epimers of novel isoquinoline‐derived SPMs were prepared, with a Pd‐catalyzed Heck reaction and a Ru(II)‐catalyzed asymmetric transfer hydrogenation as the key synthetic steps. Biological assessment demonstrated that several analogues significantly attenuate lipopolysaccharide‐induced NF‐κB activation and downstream pro‐inflammatory ...
Denise Moran, Monica de Gaetano, Braden Millar, Catherine Godson, Patrick J. Guiry   +4 more
wiley   +1 more source

Effects of Adrenal Glucocorticoids on Polyoma Virus Replication [PDF]

, 1973
Vera B. Morhenn, Zelig Rabinowitz, Gordon M. Tomkins   +2 more
openalex   +1 more source

Rare presentation of immunoglobulin G4-related disease as tracheal stenosis: a case report and review of the literature. [PDF]

Clin Rheumatol
Ata EB, Tekgöz E, Çolak S, Karaçalı E, Doğan FM, Çınar M, Yılmaz S.   +6 more
europepmc   +1 more source

Combined Immediate‐Release and Extended‐Release Formulation of Sodium Valproate Provides Stable Plasma Levels for Inhibition of Histone Deacetylation

Clinical Pharmacology in Drug Development, EarlyView.
Abstract A modified controlled‐release sodium valproate formulation (VAL001, test) was compared with an approved enteric‐coated tablet formulation (Absenor, reference). Pharmacokinetics and safety/tolerability were evaluated in healthy subjects to bridge with positive efficacy results from an early‐phase patient trial of valproate in combination with ...
Nikhil Ahuja, Susanna Kääriäinen, Zsófia Lovró, Mia Lundblad, Kristina Drott, Elsa Lilienberg, Marica T. Engström, Karla Saukkonen, Mika Scheinin   +8 more
wiley   +1 more source

Specific Cytoplasmic Glucocorticoid Hormone Receptors in Hepatoma Tissue Culture Cells

, 1971
John D. Baxter, Gordon M. Tomkins
openalex   +1 more source

Heterogeneity of Glucocorticoid Binders: A Unique and a Classical Dexamethasone-Binding Site in Bovine Tissues* [PDF]

, 1979
S. YUNG, David S. Loose, David Feldman
openalex   +1 more source

Integration of Adjunctive Therapy for Congenital Adrenal Hyperplasia. [PDF]

Children (Basel)
Speiser PW.
europepmc   +1 more source

Pharmacokinetics, Safety, and Skin Irritation and Sensitization Potential of Clascoterone Cream in Early‐Phase Clinical Study Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Clascoterone is an androgen receptor inhibitor approved for the treatment of acne vulgaris in patients 12 years of age and older. Here, we report results of 5 phase 1 studies that assessed the pharmacokinetics (PK), safety, and skin irritation and sensitization potential of clascoterone cream 1% in healthy participants and patients with acne ...
Andrea Francesco Daniele Di Stefano, Milko Massimiliano Radicioni, Gerhard Garhöfer, Martina Cartwright, Markus Müller, Iris Kopeloff, Luigi Moro, Nicholas Squittieri, Alessandro Mazzetti   +8 more
wiley   +1 more source

Purification of the glucocorticoid receptor from rat liver cytosol.

, 1979
Örjan Wränge, Jan Carlstedt‐Duke, Jan Gustafsson   +2 more
openalex   +1 more source

Risk factors for glucocorticoid induced osteoporosis in young adults. [PDF]

Front Endocrinol (Lausanne)
Florez H, Carrasco JL, Barberá M, Hernández-Rodríguez J, Muxi A, Mocritcaia A, Prieto-González S, Cid MC, Monegal A, Guañabens N, Peris P.   +10 more
europepmc   +1 more source