Results 61 to 70 of about 443,164 (406)
Brief increases in corticosterone affect morphology, stress responses, and telomere length, but not post-fledging movements, in a wild songbird [PDF]
, 2018 Organisms are frequently exposed to challenges during development, such as poor weather and food shortage. Such challenges can initiate the hormonal stress response, which involves secretion of glucocorticoids. Although the hormonal stress response helps organisms deal with challenges, long-term exposure to high levels of glucocorticoids can have ...
arxiv +1 more source
Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma.
New England Journal of Medicine, 2014 BACKGROUND Many patients with severe asthma require regular treatment with oral glucocorticoids despite the use of high-dose inhaled therapy. However, the regular use of systemic glucocorticoids can result in serious and often irreversible adverse ...
E. Bel +7 more
semanticscholar +1 more source
Function changing mutations in glucocorticoid receptor evolution correlate with their relevance to mode coupling [PDF]
, 2015 Nonlinear effects in protein dynamics are expected to play role in function, particularly of allosteric nature, by facilitating energy transfer between vibrational modes. A recently proposed method focusing on the non-Gaussian shape of the population near equilibrium projects this information onto real space in order to identify the aminoacids relevant
arxiv +1 more source
Role of glucocorticoid negative feedback in the regulation of HPA axis pulsatility
Stress, 2018 The hypothalamic–pituitary–adrenal (HPA) axis is the major neuroendocrine axis regulating homeostasis in mammals. Glucocorticoid hormones are rapidly synthesized and secreted from the adrenal gland in response to stress.
Julia K Gjerstad, S. Lightman, F. Spiga
semanticscholar +1 more source
Accessible ecophysiological tools for seabird conservation
Aquatic Conservation: Marine and Freshwater Ecosystems, Volume 32, Issue 12, Page 1983-2002, December 2022., 2022 Abstract Seabirds are the most endangered avian taxa on Earth, with over a third of species globally threatened. To help slow their decline, conservation physiology seeks to determine how seabird responses to climatic and anthropogenic threats influence demographic processes, but it is not widely utilized in monitoring.
Edin A. Whitehead, Brendon J. Dunphy
wiley +1 more source
Türk Osteoporoz Dergisi, 2017 Many side effects are encountered during the use of glucocorticoids. Osteoporosis is a common side effect of bone metabolism. The side effect increase with high dose and long-term use of steroids.
Selda Çiftci +6 more
doaj +1 more source
Glucocorticoid receptor action in metabolic and neuronal function [version 1; referees: 3 approved] [PDF]
, 2017 Glucocorticoids via the glucocorticoid receptor (GR) have effects on a variety of cell types, eliciting important physiological responses via changes in gene expression and signaling.
Garabedian, Michael J +2 more
core +3 more sources
Chronopharmacology of glucocorticoids
Advanced Drug Delivery Reviews, 2019 Glucocorticoids influence a wide array of metabolic, anti-inflammatory, immunosuppressive, and cognitive signaling processes, playing an important role in homeostasis and preservation of normal organ function. Synthesis is regulated by the hypothalamic-pituitary-adrenal (HPA) axis of which cortisol is the primary glucocorticoid in humans.
Megerle L. Scherholz +2 more
openaire +4 more sources
Glucocorticoid-induced osteoporosis: an update
Endocrine, 2018 Glucocorticoid-induced osteoporosis is the most common secondary cause of osteoporosis and the resulting fractures cause significant morbidity. Following initiation of oral glucocorticoids, rapid bone loss occurs, and fracture risk increases within a few
J. Compston
semanticscholar +1 more source
Frontiers in Immunology, 2022 BackgroundSevere autoimmune haemolytic anaemia (AIHA) in systemic lupus erythematosus (SLE) patients could be life-threatening and formidable, especially in those nonresponsive to glucocorticoids (GCs) and immunosuppressants (ISAs).
Ying Jiang +6 more
doaj +1 more source