Results 151 to 160 of about 2,524,396 (364)

Self‐Assembled Myricetin‐Arginine Conjugate Nanozymes for Targeted Suppression of Joint Inflammation and Osteoclastogenesis in Rheumatoid Arthritis

Advanced Science, EarlyView.
Carrier‐free myricetin‐arginine conjugate nanozymes (MANZs) have been fabricated through a Mannich reaction and spontaneous self‐assembly. MANZs selectively accumulate in inflamed joints by targeting M1 macrophages via CAT2‐mediated uptake. The nanozymes can effectively modulate macrophage polarization, suppress osteoclast differentiation, and mitigate
Jiachang Hong, Penghao Ji, Jinxi An, Junchao Huang, Ziheng Bu, Xudong Zhang, Wei Liu, Tingyu Wu, Sen Wang, Wei Zhu, Yuhui Li, Jixian Wan, Sudan Xu, Minfeng Huo, Peng Wu   +14 more
wiley   +1 more source

A Kinase-Independent Activity of Cdk9 Modulates Glucocorticoid Receptor-Mediated Gene Induction [PDF]

, 2014
Rong Zhu, Xinping Lu, Madhumita Pradhan, Stephen P. Armstrong, Geoffrey B. Storchan, Carson C. Chow, S. Stoney Simons   +6 more
openalex   +1 more source

Identification of Compound Heterozygous CYP11A1 Variants via Reanalysis of Clinical Sequencing Data

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT A molecular diagnosis is currently achievable in approximately 50% of patients assessed by clinical geneticists at tertiary care centres. Next‐Generation Sequencing Panels contain a defined group of genes associated with a clinically defined set of phenotypes.
Ana Acosta Bedón, Vahid Akbari, Ralph Rothstein, Alexandra Inman, Sanjiv Bhalla, Jianghong An, Jan M. Friedman, Rosanna Weksberg, Cornelius Boerkoel, Steven J. M. Jones, William T. Gibson   +10 more
wiley   +1 more source

Glucocorticoid Receptor [PDF]

, 2020
openaire   +1 more source

Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responses

Epigenetics, 2008
T. Oberlander, J. Weinberg, M. Papsdorf, R. Grunau, S. Misri, A. Devlin   +5 more
semanticscholar   +1 more source

New approaches to treating chronic obstructive pulmonary disease with Colla corii asini

Animal Models and Experimental Medicine, EarlyView.
Colla corii asini improves chronic obstructive pulmonary disease (COPD) treatment through anti‐inflammatory, antioxidant, immune‐modulatory, and lung‐nourishing effects, addressing current therapeutic challenges via multitarget mechanisms. Abstract Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death and disability ...
Wenchao Zhang, Siman Sun, Xiaoyu Fan, Jiuming He, Qing Li, Hongtao Jin   +5 more
wiley   +1 more source

Glucocorticoid Receptor

, 2018
Nicolas C. Nicolaides, Evangelia Charmandari, George P. Chrousos   +2 more
openaire   +3 more sources

Glucocorticoids regulate the glucocorticoid receptor in the AtT-20 cell.

, 1981
František Švec, Mary Rudis
openalex   +1 more source

Polydatin alleviates mitochondrial damage and apoptosis of lung epithelial cells by inhibiting toll‐like receptor 4‐dependent macrophage activation in asthma

Animal Models and Experimental Medicine, EarlyView.
The alleviation of asthma by polydatin is dependent on the blockage of the toll‐like receptor 4 (TLR4)/P2X7R synergy in macrophages. The blockage of the TLR4/P2X7R synergy results in decreased release and secretion of interleukin‐1β (IL‐1β) and IL‐18. In epithelial cells, low IL‐1β and IL‐18 levels inhibit mitochondrial damage and apoptosis.
Guangxing Li, Ruobai Liu, Chang Xu, Jianing Yang, Yilan Song, Li Li, Jingzhi Jiang, Liangchang Li, Chongyang Wang, Guanghai Yan   +9 more
wiley   +1 more source

The paradoxical effect of glucocorticoid-induced tumor necrosis factor receptor family-related gene (GITR) activation on alloreactive CD4 and CD8 T cells and the development of GVHD

, 2004
Stephanie J. Muriglan, Teresa Ramirez‐Montagut, Önder Alpdoğan, T. van Huystee, Jeffrey M. Eng, Vanessa M. Hubbard, Adam A. Kochman, Kartono H. Tjoe, Marcel R.M. van den Brink   +8 more
openalex   +1 more source