Results 271 to 280 of about 2,524,396 (364)

Targeting Hsp90 with cemdomespib reduces seizure burden and alters disease course in preclinical epilepsy models

Epilepsia, EarlyView.
Abstract Objective Epilepsy is a chronic neurological disorder characterized by recurrent seizures and frequent cognitive and psychiatric comorbidities. Although current antiseizure medications provide symptomatic relief, they fail to prevent or modify epileptogenesis.
Yara Sheeni, Prince Kumar Singh, Sereen Sandouka, Taige Zhang, Alina Nemirovski, Aseel Saadi, Rhoda Olowe Taiwo, Matthew C. Walker, Tawfeeq Shekh‐Ahmad   +8 more
wiley   +1 more source

Effects of glucocorticoid receptor activation on gene expression and antiviral responses in Atlantic salmon (Salmo salar L.) red blood cells. [PDF]

Vet Res
Tsoulia T, Sundaram AYM, Amundsen MM, Aardal MJ, Mira MS, Ploss FB, Faller R, Jensen I, Gjessing MC, Brauner C, Dahle MK.   +10 more
europepmc   +1 more source

HOXA13 exerts a beneficial effect in albumin-induced epithelial-mesenchymal transition via the glucocorticoid receptor signaling pathway in human renal tubular epithelial cells

, 2016
Li Peng, Qingnan He, Xiaoyan Li, Lanjun Shuai, Hạixia Chen, Yongzhen Li, Zhu-Wen Yi   +6 more
openalex   +2 more sources

From Receptor Balance to Rational Glucocorticoid Therapy

, 2014
E. de Kloet
semanticscholar   +1 more source

Is posttraumatic stress disorder specific to drug‐resistant epilepsy or a common feature of chronic disease? A comparative study with atrial fibrillation and type 1 diabetes

Epilepsia, EarlyView.
Abstract Objective Posttraumatic stress disorder (PTSD) is more prevalent in epilepsy than in the general population. However, it remains unclear whether this association is specific to epilepsy or a broader consequence of experiencing unpredictable acute episodes within chronic diseases.
Lisa‐Dounia Soncin, Capucine Rodet, Mina Aboulmakarim, Bernard Giusiano, Marie Arthuis, Jean‐Claude Deharo, Patrice Darmon, Olivia Ronsin, Sylvane Faure, Fabrice Bartolomei   +9 more
wiley   +1 more source

Prenatal betamethasone–postnatal N‐methyl‐D‐aspartic acid model of spasms: Update on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Infantile epilepsy spasms syndrome (IESS), formerly known as infantile spasms or West Syndrome, is a severe epilepsy syndrome affecting about 3 in 10,000 newborns in the United States. Characterized by clusters of epileptic spasms, interictal hypsarrhythmia, and developmental delays, IESS has diverse causes, including structural‐metabolic ...
Kayla Vieira, Antonia Schonwald, Chian‐Ru Chern, Kamya Shah, Jana Velíšková, Libor Velíšek   +5 more
wiley   +1 more source

<i>O</i>-GlcNAc transferase promotes immune evasion and immunotherapy resistance in uterine corpus endometrial cancer by targeting the glucocorticoid receptor. [PDF]

J Immunother Cancer
Wang J, Xie Y, Liu L, Rong S, Cai H, Zeng H, Zhou L, Deng K, Dai M, Xu C, Zhu Y, Lu Z, Song X, Zeng X, Liu S.   +14 more
europepmc   +1 more source

The multiple hit model of infantile and epileptic spasms: The 2025 update

Epilepsia Open, EarlyView.
Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou, Wenzhu B. Mowrey, Wei Liu, Anna Maria Katsarou, Qianyun Li, Oleksii Shandra, Solomon L. Moshé   +6 more
wiley   +1 more source

Methylation of the Glucocorticoid Receptor Gene in Children with Somatic Symptom Disorder: A Case-Control Study. [PDF]

Epigenomes
Hatta K, Kantake M, Tanaka K, Nakaoka H, Shimizu T, Shoji H.   +5 more
europepmc   +1 more source

Insect‐Derived Bioactives for Glycemic Control and Gut Health: A Review

Food Frontiers, EarlyView.
Insect‐derived bioactive compounds (e.g., peptides, polysaccharides) effectively regulate blood glucose through dual mechanisms: directly inhibiting carbohydrate‐digesting enzymes and glucose transporters, and indirectly modulating gut microbiota to enhance intestinal barrier integrity.
Chaoyi Lv, Yuanyuan Huang, Mokhtar Dabbour, Benjamin Kumah Mintah, Ronghai He, Haile Ma   +5 more
wiley   +1 more source