Results 61 to 70 of about 142,613 (313)

The Glucocorticoid Receptor: A Revisited Target for Toxins

Toxins, 2010
The hypothalamic-pituitary-adrenal (HPA) axis activation and glucocorticoid responses are critical for survival from a number of bacterial, viral and toxic insults, demonstrated by the fact that removal of the HPA axis or GR blockade enhances mortality ...
Jeanette I. Webster Marketon, Esther M. Sternberg   +1 more
doaj   +1 more source

Glucocorticoid modulates angiotensin II receptor expression patterns and protects the heart from ischemia and reperfusion injury. [PDF]

PLoS ONE, 2014
Glucocorticoid regulates angiotensin II receptor (ATR) expression via activating glucocorticoid receptors and binding to glucocorticoid response elements.
Qin Xue, Andrew J Patterson, Daliao Xiao, Lubo Zhang   +3 more
doaj   +1 more source

Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice [PDF]

, 2003
Obesity is closely associated with the metabolic syndrome, a combination of disorders including insulin resistance, diabetes, dyslipidemia, and hypertension.
Kenyon, C J, Joel K. Elmquist, Elmquist, Joel K., Flier, Jeffrey S., Jonathan R. Seckl, Yamamoto, H, Yamamoto, Hiroshi, Mullins, J J, John J. Mullins, Shinyama, H, Shinyama, Hiroshi, Masuzaki, H, Nicholas M. Morton, Janice M. Paterson, Paterson, Janice M., Sharp, M G F, Jeffrey S. Flier, Seckl, J R, Sharp, Matthew G. F., Masuzaki, Hiroaki, Paterson, J M, Matthew G.F. Sharp, Seckl, Jonathan R., Hiroshi Yamamoto, Morton, Nicholas M., Stewart Fleming, Elmquist, J K, Morton, N M, Hiroaki Masuzaki, Flier, J S, Mullins, John J., Fleming, S, Hiroshi Shinyama, Fleming, Stewart, Kenyon, Christopher J., Christopher J. Kenyon   +35 more
core   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

PU.1 eviction at lymphocyte-specific chromatin domains mediates glucocorticoid response in acute lymphoblastic leukemia

Nature Communications
The epigenetic landscape plays a critical role in cancer progression, yet its therapeutic potential remains underexplored. Glucocorticoids are essential components of treatments for lymphoid cancers, but resistance, driven in part by epigenetic changes ...
Dominik Beck, Honghui Cao, Feng Tian, Yizhou Huang, Miao Jiang, Han Zhao, Xiaolu Tai, Wenqian Xu, Hansen J. Kosasih, David J. Kealy, Weiye Zhao, Samuel J. Taylor, Timothy A. Couttas, Gaoxian Song, Diego Chacon-Fajardo, Yashna Walia, Meng Wang, Adam A. Dowle, Andrew N. Holding, Katherine S. Bridge, Chao Zhang, Jin Wang, Jian-Qing Mi, Richard B. Lock, Charles E. de Bock, Duohui Jing   +25 more
doaj   +1 more source

GR and LSD1/KDM1A-Targeted Gene Activation Requires Selective H3K4me2 Demethylation at Enhancers

Cell Reports, 2019
Summary: KDM1A-mediated H3K4 demethylation is a well-established mechanism underlying transcriptional gene repression, but its role in gene activation is less clear.
Erin A. Clark, Feizhen Wu, Yirui Chen, Paco Kang, Ursula B. Kaiser, Rui Fang, Yujiang G. Shi   +6 more
doaj   +1 more source

Effect of acute adrenalectomy on rat liver glucocorticoid receptor [PDF]

Archives of Biological Sciences, 2006
In order to improve current clinical treatment of human hypocortisolism, it is necessary to understand molecular aspects of this pathophysiology. In this study liver tissues from male Wistar rats were used as an experimental model to study structural and
Isenović Esma R., Radojčić Marija, Žakula Zorica, Korićanac Goran, Ribarac-Stepić Nevena   +4 more
doaj   +1 more source

3D models of lamprey corticoid receptor complexed with 11-deoxycortisol and deoxycorticosterone

, 2011
The serum of Atlantic sea lamprey, a basal vertebrate, contains two corticosteroids, 11-deoxycortisol and deoxycorticosterone. Only 11-deoxycortisol has high affinity [Kd~3 nM] for the corticoid receptor [CR] in lamprey gill cytosol. To investigate the
Paiyuam Asnaashari, Michael E. Baker, Kayla Y. Uh   +2 more
core   +1 more source

CAR T‐Cell Therapy in Neurology: A Scoping Review of Neuro‐Oncology, Autoimmune Diseases & Neurotoxicity

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi, Mohammed Dibas, Patricia Tai, Ala Dibas, Osama Souied, Suhair Al‐Ghabeesh   +5 more
wiley   +1 more source

Plasma Proteomics in Healthy Subjects with Differences in Tissue Glucocorticoid Sensitivity Identifies A Novel Proteomic Signature

Biomedicines, 2022
Significant inter-individual variation in terms of susceptibility to several stress-related disorders, such as myocardial infarction and Alzheimer’s disease, and therapeutic response has been observed among healthy subjects.
Nicolas C. Nicolaides, Manousos Makridakis, Rafael Stroggilos, Vasiliki Lygirou, Eleni Koniari, Ifigeneia Papageorgiou, Amalia Sertedaki, Jerome Zoidakis, Evangelia Charmandari   +8 more
doaj   +1 more source