Results 131 to 140 of about 2,312,594 (289)

Ferroptosis-mediated metabolic reprogramming as a driver of the inflammatory microenvironment in neutrophilic asthma: a perspective

Frontiers in Immunology
Neutrophilic asthma is a severe asthma subtype marked by persistent airway neutrophilia, Th17-skewed inflammation, and poor responsiveness to glucocorticoids.
Mei-zhen Song, Xue-hui Wang
doaj   +1 more source

Research progress of glucocorticoid resistance in chronic rhinosinusitis with nasal polyps: A review. [PDF]

Medicine (Baltimore), 2023
Chen L, Fan X, Yang L, Han L, Wang N, Bian K.   +5 more
europepmc   +1 more source

Short‐term clinical responses in horses and ponies treated with canagliflozin: A clinical field study

Equine Veterinary Journal, EarlyView.
Abstract Background Treatment with the sodium‐glucose co‐transporter 2 (SGLT2) inhibitor canagliflozin in insulin dysregulated (ID) horses has shown promising results in randomised clinical trials. Larger field studies are needed to further evaluate treatment responses and potential adverse effects under real‐world conditions.
Moa Hällbom, Sanna Truelsen Lindåse, Monika Wartel, Johan Bröjer   +3 more
wiley   +1 more source

JUN mediates glucocorticoid resistance by stabilizing HIF1a in T cell acute lymphoblastic leukemia. [PDF]

iScience, 2023
Zhang Z, Shi J, Wu Q, Zhang Z, Liu X, Ren A, Zhao G, Dong G, Wu H, Zhao J, Zhao Y, Hu J, Li H, Zhang T, Zhou F, Zhu H.   +15 more
europepmc   +1 more source

Acupuncture Alleviates Allergic Rhinitis by Activating the AMPK/PGC‐1α Pathway to Attenuate Mitochondrial Oxidative Stress and Restore Epithelial Barrier Function

Flavour and Fragrance Journal, EarlyView.
Acupuncture at Feishu (BL13), Shenshu (BL23), Yingxiang (LI20), and Dazhui (GV14) alleviates allergic rhinitis by activating the AMPK/PGC‐1α/NRF1/TFAM signalling axis. This activation improves mitochondrial biogenesis and function, reduces mtROS‐mediated oxidative stress, restores ATP production and respiratory complex I/IV activity, suppresses IgE and
Fengying Zhang, Wei Meng, Renzhong Wang, Huijun Du   +3 more
wiley   +1 more source

MOLECULAR MECHANISMS AND METABOLIC CONSEQUENCES OF GLUCOCORTICOID RESISTANCE

Glucocorticoids are vital steroid hormones that govern metabolism, stress responses, and immune functions through intricate, tissue-specific mechanisms, both genomic and non-genomic.
Martinez, Genesee J.
core   +1 more source

Convergence of MTOR and Glucocorticoid receptor signalling in the human placenta: effects of pre-term labour, nutrition and maternal stress [PDF]

, 2011
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.A vital factor for foetal development is the nutrient transport at placental level.
Mparmpakas, Dionisis G.
core   +1 more source

Transcutaneous auricular vagus nerve stimulation inhibits mental stress‐induced cortisol release—Potential implications for inflammatory conditions

Physiological Reports
Elevated glucocorticoid levels with reduced glucocorticoid responsiveness have been reported in chronic inflammatory conditions. Activation of neurons in the nucleus of the solitary tract by transcutaneous auricular vagus nerve stimulation (taVNS) may ...
Ely Cuberos Paredes, Domenica Goyes, Sadie Mak, Raffi Yardimian, Nickolas Ortiz, Ayana McLaren, Harald M. Stauss   +6 more
doaj   +1 more source

Beyond Gut Modulation: A Critical Review of the Therapeutic Potential, Safety, and Clinical Prospects of Natural Polysaccharides for IBD

Food Safety and Health, EarlyView.
In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso, A. M. Abd El‐Aty, Kwaku Amoah, Xianghong Ju   +3 more
wiley   +1 more source

A novel mutation in the NR3C1 gene associated with reversible glucocorticoid resistance: Reversible glucocorticoid resistance: case report

International audienceAbstract Objective Glucocorticoid resistance is a rare endocrine disease caused by variants of the NR3C1 gene encoding the glucocorticoid receptor (GR).
Perrot, Julie, Lebigot, Elise, Amazit, Larbi, Lombès, Marc, Martinerie, Laetitia, Kamenickỷ, Peter, Viengchareun, Say, Bouligand, Jérôme, Fagart, Jérôme, Laulhé, Margaux, Kuhn, Emmanuelle   +10 more
core   +1 more source