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Glucocorticoid resistance in inflammatory diseases
The Lancet, 2009Glucocorticoid resistance or insensitivity is a major barrier to the treatment of several common inflammatory diseases-including chronic obstructive pulmonary disease and acute respiratory distress syndrome; it is also an issue for some patients with asthma, rheumatoid arthritis, and inflammatory bowel disease.
Peter J, Barnes, Ian M, Adcock
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2010
Changes in glucocorticoid (GC) receptor sensitivity can be categorized in three different types. First, generalized GC resistance syndrome is a hereditary disease. Patients present with signs and symptoms of increased androgen and/or mineralocorticoid action, combined with biochemical hypercortisolism, but lack of cushingoid features.
E F C, van Rossum, E L T, van den Akker
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Changes in glucocorticoid (GC) receptor sensitivity can be categorized in three different types. First, generalized GC resistance syndrome is a hereditary disease. Patients present with signs and symptoms of increased androgen and/or mineralocorticoid action, combined with biochemical hypercortisolism, but lack of cushingoid features.
E F C, van Rossum, E L T, van den Akker
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Glucocorticoid Feedback Resistance
Trends in Endocrinology & Metabolism, 1997Glucocorticoid feedback resistance can be inherited or locally acquired. The implications of these two forms of resistance for disease are strikingly different. The inherited form is characterized by enhanced adrenocortical function and hypercorticism to compensate for a generalized deficit in the glucocorticoid receptor gene, but these individuals ...
de Kloet, E.R. +3 more
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Glucocorticoid-resistant asthma
Current Allergy and Asthma Reports, 2002Glucocorticoids are currently the most effective anti-inflammatory therapy for asthma. However, a small subset of asthma sufferers do not respond to clinically relevant doses of glucocorticoids and are termed "glucocorticoid resistant." These patients are characterized by increased bronchial hyperreactivity, lower morning peak expiratory flow rates ...
Loke, T K +3 more
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Glucocorticoid Resistance and Hypersensitivity
Endocrinology and Metabolism Clinics of North America, 2005This article emphasizes the disorders caused by mutations and polymorphisms of the alpha form of the glucocorticoid receptor. These disorders usually present with increased circulating cortisol concentrations and must be distinguished from Cushing's syndrome, because the therapies are markedly different.
Carl D, Malchoff, Diana M, Malchoff
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Biochemistry (Moscow), 2006
Glucocorticoids contribute fundamentally to the maintenance of basal and stress-related homeostasis in all higher organisms. The major roles of these steroids in physiology are amply matched by their remarkable contributions to pathology. Glucocorticoid resistance is a rare familial, or sporadic condition characterized by partial end-organ ...
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Glucocorticoids contribute fundamentally to the maintenance of basal and stress-related homeostasis in all higher organisms. The major roles of these steroids in physiology are amply matched by their remarkable contributions to pathology. Glucocorticoid resistance is a rare familial, or sporadic condition characterized by partial end-organ ...
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Syndromes of Glucocorticoid Resistance
Annals of Internal Medicine, 1993Glucocorticoid resistance results from the partial, albeit apparently generalized, inability of glucocorticoids to exert their effects on target tissues. The condition is associated with compensatory increases in circulating pituitary corticotropin and cortisol, with the former causing excess secretion of both adrenal androgens and adrenal steroid ...
G P, Chrousos +2 more
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Glucocorticoid resistance in humans
Trends in Endocrinology & Metabolism, 1995Generalized inherited glucocorticoid resistance is a rare disorder caused by glucocorticoid receptor mutations and characterized clinically by hypercortisolism. Pituitary and peripheral resistance are balanced so that neither adrenal insufficiency nor Cushingoid features develop.
C D, Malchoff, D M, Malchoff
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Molecular mechanisms of glucocorticoid resistance
European Journal of Clinical Investigation, 2022AbstractBackgroundAs a powerful anti‐inflammatory, immunosuppressive, and antiproliferative drug, glucocorticoid (GC) plays an important role in the treatment of various diseases. However, some patients may experience glucocorticoid resistance (GCR) in clinical, and its molecular mechanism have not been determined.MethodsThe authors performed a review ...
Huanming Huang, Wenqing Wang
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Glucocorticoid Resistance in Asthma
American Journal of Respiratory and Critical Care Medicine, 1995Glucocorticoids are highly effective in the control of asthma and other chronic inflammatory or immune diseases. The value of steroids in asthma became apparent soon after the introduction of adrenocorticotrophic hormone in 1949 (1). The efficacy of steroids was rapidly confirmed by clinical trials (2,3), and steroids quickly became established as an ...
P J, Barnes +2 more
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