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Glucocorticoid resistance — what is known?
Current Opinion in Pharmacology, 2002It has become apparent in recent years that the glucocorticoid receptor is not a simple on/off switch, but instead orchestrates subtle and complex interactions between large numbers of proteins. This more sophisticated understanding awaits a unifying concept that will explain mechanisms of glucocorticoid resistance and allow new approaches to enhancing
Michael Norman, M Norman
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Glucocorticoid resistance—a defect of the glucocorticoid receptor
, 2011 Abstract The first case of glucocorticoid resistance was reported in 1976 by Vingerhoeds et al. (1). The patient was suffering from hypercortisolism with none of the tissue effects of Cushing’s disease. Further evaluation revealed that the ligand-binding affinity of the glucocorticoid receptor (GR) was diminished. His son and nephew were
Elisabeth F. C. van Rossum +1 more
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The genetic basis of glucocorticoid resistance
Trends in Endocrinology & Metabolism, 1995 Familial glucocorticoid resistance is a rare syndrome characterized by elevated levels of plasma cortisol but lacking the symptoms of Cushing's syndrome. Biochemically, the condition is characterized by a relative resistance to glucocorticoids that can be compensated for by the elevated levels of cortisol.
M, Brönnegård, J, Carlstedt-Duke
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2010
Changes in glucocorticoid (GC) receptor sensitivity can be categorized in three different types. First, generalized GC resistance syndrome is a hereditary disease. Patients present with signs and symptoms of increased androgen and/or mineralocorticoid action, combined with biochemical hypercortisolism, but lack of cushingoid features.
van Rossum, Liesbeth, Lamberts, S.W.J.
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Changes in glucocorticoid (GC) receptor sensitivity can be categorized in three different types. First, generalized GC resistance syndrome is a hereditary disease. Patients present with signs and symptoms of increased androgen and/or mineralocorticoid action, combined with biochemical hypercortisolism, but lack of cushingoid features.
van Rossum, Liesbeth, Lamberts, S.W.J.
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Glucocorticoid Feedback Resistance
Trends in Endocrinology & Metabolism, 1997Glucocorticoid feedback resistance can be inherited or locally acquired. The implications of these two forms of resistance for disease are strikingly different. The inherited form is characterized by enhanced adrenocortical function and hypercorticism to compensate for a generalized deficit in the glucocorticoid receptor gene, but these individuals ...
de Kloet, E.R. +3 more
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Glucocorticoid Resistance and Hypersensitivity
Endocrinology and Metabolism Clinics of North America, 2005This article emphasizes the disorders caused by mutations and polymorphisms of the alpha form of the glucocorticoid receptor. These disorders usually present with increased circulating cortisol concentrations and must be distinguished from Cushing's syndrome, because the therapies are markedly different.
Carl D, Malchoff, Diana M, Malchoff
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Syndromes of Glucocorticoid Resistance
Annals of Internal Medicine, 1993Glucocorticoid resistance results from the partial, albeit apparently generalized, inability of glucocorticoids to exert their effects on target tissues. The condition is associated with compensatory increases in circulating pituitary corticotropin and cortisol, with the former causing excess secretion of both adrenal androgens and adrenal steroid ...
G P, Chrousos +2 more
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Glucocorticoid Resistance in Asthma
American Journal of Respiratory and Critical Care Medicine, 1995Glucocorticoids are highly effective in the control of asthma and other chronic inflammatory or immune diseases. The value of steroids in asthma became apparent soon after the introduction of adrenocorticotrophic hormone in 1949 (1). The efficacy of steroids was rapidly confirmed by clinical trials (2,3), and steroids quickly became established as an ...
P J, Barnes +2 more
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Glucocorticoid-resistant asthma
Current Allergy and Asthma Reports, 2002Glucocorticoids are currently the most effective anti-inflammatory therapy for asthma. However, a small subset of asthma sufferers do not respond to clinically relevant doses of glucocorticoids and are termed "glucocorticoid resistant." These patients are characterized by increased bronchial hyperreactivity, lower morning peak expiratory flow rates ...
Loke, T K +3 more
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Glucocorticoid resistance in humans
Trends in Endocrinology & Metabolism, 1995Generalized inherited glucocorticoid resistance is a rare disorder caused by glucocorticoid receptor mutations and characterized clinically by hypercortisolism. Pituitary and peripheral resistance are balanced so that neither adrenal insufficiency nor Cushingoid features develop.
C D, Malchoff, D M, Malchoff
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