Results 251 to 260 of about 126,176 (294)
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Glucocorticoid Resistance in Childhood Leukemia
Leukemia & Lymphoma, 1994Glucocorticoids (GC) are being used in the treatment of childhood leukemia for several decades, most successfully in newly diagnosed acute lymphoblastic leukemia (ALL). However, GC resistance is seen in 10-30% of untreated ALL patients, and is much more frequent in relapsed ALL and in acute nonlymphoblastic leukemia (ANLL). Sensitivity or resistance to
Kaspers, G. J.L. +4 more
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Antiprogestins and iatrogenic glucocorticoid resistance
Life Sciences, 1997The antiglucocorticoid action of the antiprogestin RU 38486 has interfered with its successful clinical application in long-term treatment. Several new antiprogestins (Org 31710, Org 31806 and ZK 98299) have recently been developed with the aim to eliminate this side-effect.
Koper, Frans +4 more
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Baillière's Clinical Endocrinology and Metabolism, 1994
Summary Familial glucocorticoid resistance results from the partial inability of glucocorticoids to exert their effects on their target tissues throughout the organism. The condition is associated with compensatory elevations of circulating ACTH and cortisol, with the former causing excess abnormal secretion of steroids with mineralocorticoid and ...
Keiko Arai, George P. Chrousos
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Summary Familial glucocorticoid resistance results from the partial inability of glucocorticoids to exert their effects on their target tissues throughout the organism. The condition is associated with compensatory elevations of circulating ACTH and cortisol, with the former causing excess abnormal secretion of steroids with mineralocorticoid and ...
Keiko Arai, George P. Chrousos
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Glucocorticoid‐resistant asthma
Clinical & Experimental Allergy Reviews, 2004SummaryIn the past decade it has become clear that asthmatic patients who are clinically unresponsive, or “resistant” to glucocorticoid therapy may have T cells which manifest resistance to glucocorticoid inhibition. This is shown by failure of glucocorticoid not only to repress the production of pro‐inflammatory, asthma‐relevant cytokines such as IL‐5,
C. J. Corrigan +3 more
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Glucocorticoid resistance — what is known?
Current Opinion in Pharmacology, 2002It has become apparent in recent years that the glucocorticoid receptor is not a simple on/off switch, but instead orchestrates subtle and complex interactions between large numbers of proteins. This more sophisticated understanding awaits a unifying concept that will explain mechanisms of glucocorticoid resistance and allow new approaches to enhancing
Michael, Norman, Stephen D, Hearing
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Tissue glucocorticoid resistance/hypersensitivity syndromes
The Journal of Steroid Biochemistry and Molecular Biology, 2003Glucocorticoids have a broad array of life-sustaining functions and play an important role in the therapy of many diseases. Thus, changes of tissue sensitivity to glucocorticoids may be associated with and influence the course and treatment of many pathologic states.
Tomoshige, Kino +4 more
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Current concepts in glucocorticoid resistance
Steroids, 2012Glucocorticoids (GCs) are the most potent anti-inflammatory agents known. A major factor limiting their clinical use is the wide variation in responsiveness to therapy. The high doses of GC required for less responsive patients means a high risk of developing very serious side effects. Variation in sensitivity between individuals can be due to a number
Yang, Nan +2 more
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Glucocorticoid Receptors and Resistance to Glucocorticoids in Hematologic Malignancies
Leukemia & Lymphoma, 1994Glucocorticoids are highly effective in inducing the cytolysis of cells of lymphocytic origin. This property has resulted in their incorporation into chemotherapy regimens used in the treatment of hematologic malignancies. Studies at the molecular and cellular levels have demonstrated that the hormone-induced cytolytic response is mediated through a ...
P A, Moalli, S T, Rosen
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Glucocorticoid resistance—a defect of the glucocorticoid receptor
2011Abstract The first case of glucocorticoid resistance was reported in 1976 by Vingerhoeds et al. (1). The patient was suffering from hypercortisolism with none of the tissue effects of Cushing’s disease. Further evaluation revealed that the ligand-binding affinity of the glucocorticoid receptor (GR) was diminished. His son and nephew were
Elisabeth F. C. van Rossum +1 more
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