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Glucocorticoid Receptors and Resistance to Glucocorticoids in Hematologic Malignancies
Leukemia & Lymphoma, 1994Glucocorticoids are highly effective in inducing the cytolysis of cells of lymphocytic origin. This property has resulted in their incorporation into chemotherapy regimens used in the treatment of hematologic malignancies. Studies at the molecular and cellular levels have demonstrated that the hormone-induced cytolytic response is mediated through a ...
P A, Moalli, S T, Rosen
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Antiprogestins and iatrogenic glucocorticoid resistance
Life Sciences, 1997The antiglucocorticoid action of the antiprogestin RU 38486 has interfered with its successful clinical application in long-term treatment. Several new antiprogestins (Org 31710, Org 31806 and ZK 98299) have recently been developed with the aim to eliminate this side-effect.
Koper, Frans +4 more
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Molecular mechanisms of glucocorticoid resistance
European Journal of Clinical Investigation, 2022AbstractBackgroundAs a powerful anti‐inflammatory, immunosuppressive, and antiproliferative drug, glucocorticoid (GC) plays an important role in the treatment of various diseases. However, some patients may experience glucocorticoid resistance (GCR) in clinical, and its molecular mechanism have not been determined.MethodsThe authors performed a review ...
Huanming Huang, Wenqing Wang
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Syndromes of glucocorticoid and mineralocorticoid resistance
Steroids, 1995Glucocorticoid resistance results from incomplete but apparently generalized inability of glucocorticoids to exert their effects on their target tissues. The condition is associated with compensatory elevation of circulating ACTH and cortisol, with the former causing excess secretion of both adrenal androgens and adrenal steroid biosynthesis ...
K, Arai, G P, Chrousos
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Update on glucocorticoid action and resistance
Journal of Allergy and Clinical Immunology, 2006Extensive development of inhaled and oral glucocorticoids has resulted in highly potent molecules that have been optimized to target activity to the lung and minimize systemic exposure. These have proved highly effective for most asthmatic subjects, but despite these developments, there are a number of subjects with asthma who fail to respond to even ...
Kazuhiro, Ito +2 more
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Glucocorticoid resistance in inflammatory diseases
The Lancet, 2009Glucocorticoid resistance or insensitivity is a major barrier to the treatment of several common inflammatory diseases-including chronic obstructive pulmonary disease and acute respiratory distress syndrome; it is also an issue for some patients with asthma, rheumatoid arthritis, and inflammatory bowel disease.
Peter J, Barnes, Ian M, Adcock
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Update on glucocorticoid action and resistance
Journal of Allergy and Clinical Immunology, 2003Glucocorticoids (GCs) are the most common group of medications used in the treatment of allergic and autoimmune disorders. They produce potent anti-inflammatory effects by inducing or repressing the expression of target genes. Although most patients with allergic diseases and autoimmune disorders respond to GC therapy, a small subset of patients ...
Harold S. Nelson +2 more
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Molecular mechanisms of glucocorticoid resistance
Journal of Endocrinology, 1996Abstract Both generalised and tissue-specific glucocorticoid resistance is increasingly being recognised. In one study, 1–2% of patients evaluated for adrenal disorders were glucocorticoid-resistant (Werner et al. 1992). At the molecular level, resistance to glucocorticoids is usually defined using specific markers.
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Syndromes of glucocorticoid and mineralocorticoid resistance
European Journal of Endocrinology, 1998s of the 13th International Symposium of the Journal of Steroid Biochemistry and Molecular Biology Monaco, May 25– 28199733-L. 60 Marver D. The mineralocorticoid receptor. In Biochemical Actions of Hormones, edn 12, pp 385–431. Ed J Litwacks. New York: Academic Press Inc, 1985. 61 Reul JMHM & de Kloet ER.
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