Results 171 to 180 of about 241,090 (306)

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source

Absence of Interaction Between 5α-Reductase Inhibitors and Glucocorticoids on Incidence of Myocardial Infarction in People With Type 2 Diabetes. [PDF]

Diabetes Obes Metab
Tu H, Ju C, McGurnaghan SJ, Blackbourn LAK, Scottish Diabetes Research Network Epidemiology Group, Pearson ER, Wei L, Andrew R.   +7 more
europepmc   +1 more source

Cortisol homeostasis and glucocorticoid signaling are altered in FMR1 full mutation and premutation carriers [PDF]

Heena mushtaq, Mudasir Manzoor Reshi, Seema Hussain, Adan Hafiz, Abrar Qurashi   +4 more
openalex   +1 more source

Tezepelumab in Chinese Patients With Severe Chronic Rhinosinusitis With Nasal Polyps: A Prespecified Subgroup Analysis of the Phase 3 WAYPOINT Trial

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) in Chinese patients often exhibits a mixed Type 1/2/3 inflammatory phenotype (63%), potentially impacting the efficacy of biologics targeting Type 2 inflammation. This prespecified subgroup analysis of WAYPOINT (NCT04851964) evaluated the efficacy and safety of tezepelumab in Chinese
Li Hu, Houyong Li, Xicai Sun, Quan Liu, Yu Xu, Jiangang Fan, Andrew Foster, Claudia Chen, Yun Chon, Dehui Wang   +9 more
wiley   +1 more source

Architect or Destroyer: The Diversity of Glucocorticoid Receptor Signaling Pathways in the Brain. [PDF]

Int J Mol Sci
Shkarina L, Khaybullina R, Primak A, Bozov K, Dzhauari S, Karagyaur M.   +5 more
europepmc   +1 more source

Hippocampal Glial Alterations Are Associated with Mitochondrial Changes and Reduced Glucocorticoid Receptor Density in Suicides

Andrea Judith Vázquez-Hernández, Yali Escribano-Cadena, Julio César Morales‐Medina, Amira Flores, Laura Alejandra Mendoza-Larios, Roberto Mendoza-Morales, Humberto Nicolini, Hiram Tendilla‐Beltrán, Fernando García‐Dolores, Gonzalo Flores   +9 more
openalex   +1 more source

Microbial‐Metabolite Signatures Are Associated With Glucocorticoid Responsiveness in Chronic Rhinosinusitis With Nasal Polyps

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) exhibit heterogeneous responses to oral glucocorticoids (GCs), but the biological basis of this variability remains unclear. Objective To identify gut microbiome‒plasma metabolomic signatures associated with GC responsiveness in CRSwNP patients and to compare their ...
Ying‐Ying Zhang, Xin‐Yu Ding, Mei‐Ping Lu, Yan‐Bing Chen, Ye Yuan, Lin Jiang, Min Zhang, Lei Cheng   +7 more
wiley   +1 more source

Infliximab Monotherapy as First-Line Treatment for Hepatic, Splenic, and Pulmonary Sarcoidosis in a Patient With High Cardiometabolic Risk. [PDF]

Cureus
Coimbra M, Saca C, Carvalho MC, Neves M, Delgado Alves J.   +4 more
europepmc   +1 more source

Additional B‐Lymphocyte Stimulator Inhibitors Treatment Facilitated Glucocorticoid Withdrawal in Lupus Nephritis Patients: A Real‐World Retrospective Observational Single‐Center Cohort Study

Jingjing Jin, Meng Tan, Minghui Zhao, Ying Tan   +3 more
openalex   +1 more source

A putative pharmacodynamic ceiling for topical corticosteroids in atopic dermatitis: a steroid-primed inflammasome and caspase-1–mediated glucocorticoid receptor cleavage [PDF]

Seung-Yong Seong
openalex   +1 more source