Results 41 to 50 of about 291,048 (366)

Repression of the Glucocorticoid Receptor Aggravates Acute Ischemic Brain Injuries in Adult Mice. [PDF]

, 2018
Strokes are one of the leading causes of mortality and chronic morbidity in the world, yet with only limited successful interventions available at present.
Concepcion, Katherine R, Fu, Yingjie, Huang, Lei, Li, Yong, Ma, Qingyi, Song, Minwoo A, Xiao, Daliao, Zhang, Lubo, Zhang, Peng   +8 more
core   +2 more sources

Fibrotic pathways and fibroblast-like synoviocyte phenotypes in osteoarthritis

Frontiers in Immunology
Osteoarthritis (OA) is the most common form of arthritis, characterized by osteophyte formation, cartilage degradation, and structural and cellular alterations of the synovial membrane.
Alexandra Damerau, Alexandra Damerau, Emely Rosenow, Dana Alkhoury, Frank Buttgereit, Frank Buttgereit, Timo Gaber, Timo Gaber   +7 more
doaj   +1 more source

Trends and Patterns of Systemic Glucocorticoid Prescription in Primary Care Institutions in Southwest China, from 2018 to 2021

Risk Management and Healthcare Policy, 2023
Xiaoyi Li,1,* Zhen Zeng,2,* Xingying Fan,1,3 Wenju Wang,4 Xiaobo Luo,4 Junli Yang,1 Yue Chang1,3,* 1School of Medicine and Health Management, Guizhou Medical University, Guiyang, Guizhou Province, People’s Republic of China; 2Second ...
Li X, Zeng Z, Fan X, Wang W, Luo X, Yang J, Chang Y   +6 more
doaj  

Bad to the Bone: The Effects of Therapeutic Glucocorticoids on Osteoblasts and Osteocytes

Frontiers in Endocrinology, 2022
Despite the continued development of specialized immunosuppressive therapies in the form of monoclonal antibodies, glucocorticoids remain a mainstay in the treatment of rheumatological and auto-inflammatory disorders.
Manuel Gado, Ulrike Baschant, Ulrike Baschant, Lorenz C. Hofbauer, Lorenz C. Hofbauer, Lorenz C. Hofbauer, Holger Henneicke, Holger Henneicke, Holger Henneicke   +8 more
doaj   +1 more source

The glucocorticoid-Angptl4-ceramide axis induces insulin resistance through PP2A and PKCζ. [PDF]

, 2017
Chronic glucocorticoid exposure is associated with the development of insulin resistance. We showed that glucocorticoid-induced insulin resistance was attenuated upon ablation of Angptl4, a glucocorticoid target gene encoding the secreted protein ...
Benjamin, Daniel I, Chen, Tzu-Chieh, Costello, Damian E, Kuo, Taiyi, Lee, Rebecca A, Li, Mei-Lan, Mar, Darryl J, Nomura, Daniel K, Wang, Jen-Chywan   +8 more
core   +1 more source

Glucocorticoids Suppress Antimicrobial Autophagy and Nitric Oxide Production and Facilitate Mycobacterial Survival in Macrophages

Scientific Reports, 2017
Chronic administration of glucocorticoids has been shown to render individuals highly susceptible to mycobacterial infection and lead to reactivation of latent bacilli.
Jinli Wang, Ruining Wang, Hui Wang, Xiaofan Yang, Jiahui Yang, Wenjing Xiong, Qian Wen, Li Ma   +7 more
doaj   +1 more source

Tissue-Specific Actions of Glucocorticoids on Apoptosis: A Double-Edged Sword

Cells, 2013
First described for their metabolic and immunosuppressive effects, glucocorticoids are widely prescribed in clinical settings of inflammation. However, glucocorticoids are also potent inducers of apoptosis in many cell types and tissues. This review will
Amanda L. Gruver-Yates, John A. Cidlowski   +1 more
doaj   +1 more source

Life Course Impact of Glucocorticoids During Pregnancy on Muscle Development and Function

Frontiers in Animal Science, 2021
Maternal stress, such as maternal obesity, can induce severe gestational disease and hormonal disorder which may disrupt fetal organ maturation and further cause endangered early or future health in offspring.
Yang Liu, Qiyue Ding, Wei Guo
doaj   +1 more source

気管支喘息における気管支肺胞洗浄液中の細胞成分に対する加齢および副腎皮質ホルモンの影響 [PDF]

, 2002
Effects of aging and glucocorticoid therapy on bronchoalveolar lavage (BAL) cells, particularly lymphocytes, neutrophils and eosinophils, were examined in 81 patients with asthma. 1.
Ashida, Kozo, Hosaki, Yasuhiro, Mitsunobu, Fumihiro, Nishida, Norikazu, Okamoto, Makoto, Takata, Shingo, Tanizaki, Yoshiro, Tsugeno, Hirofumi, Yokoi, Tadashi   +8 more
core   +1 more source

Alendronate or alfacalcidol in glucocorticoid-induced osteoporosis [PDF]

, 2006
BACKGROUND: Treatment with glucocorticoids is associated with bone loss starting soon after therapy is initiated and an increased risk of fracture. METHODS: We performed a randomized, double-placebo, double-blind clinical trial of 18 months' duration ...
Ale Algra, Anne-Margriet Huisman, Ans C.M. Oostveen, Ben A.C. Dijkmans, Chris E.D. de Laet, de Nijs RN, Erik Buskens, George A.W. Bruyn, Johannes W.G. Jacobs, Johannes W.J. Bijlsma, Michel BA, Piet P.M.M. Geusens, Roland F.J. Laan, Ron N.J. de Nijs, Willem F. Lems   +14 more
core   +4 more sources