Glucocorticoids rapidly inhibit oxytocin-stimulated adrenocorticotropin release from rat anterior pituitary cells, without modifying intracellular calcium transients [PDF]
, 1993 Glucocorticoid hormones suppress the secretion of ACTH evoked by secretagogues such as CRF and arginine vasopressin. In this study, we investigated the effects of glucocorticoids on ACTH release induced by oxytocin (OT) and on intracellular free calcium ...
Link, H., Dayanithi, G., Gratzl, Manfred
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Glucocorticoid-induced osteoporosis – a disorder of mesenchymal stromal cells?
Frontiers in Endocrinology, 2011 Glucocorticoids are a class of steroid hormones that are essential to life but cause serious harm in excess. The main clinical features of glucocorticoid excess are due to adverse effects on cells and tissues that arise from a common developmental ...
Mark Stuart Cooper, Rowan eHardy
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Improvement of Treg immune response after treatment with tocilizumab in giant cell arteritis
Clinical & Translational Immunology, 2021 Objectives To study the percentage, suppressive function and plasticity of Treg in giant cell arteritis (GCA), and the effects of glucocorticoids and tocilizumab.
Maxime Samson +27 more
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Single-Cell Resolution and Quantitation of Targeted Glucocorticoid Delivery in the Thymus
Cell Reports, 2019 Summary: Glucocorticoids are lipid-soluble hormones that signal via the glucocorticoid receptor (GR), a ligand-dependent transcription factor. Circulating glucocorticoids derive from the adrenals, but it is now apparent that paracrine glucocorticoid ...
Matthew D. Taves +4 more
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Fibrotic pathways and fibroblast-like synoviocyte phenotypes in osteoarthritis
Frontiers in ImmunologyOsteoarthritis (OA) is the most common form of arthritis, characterized by osteophyte formation, cartilage degradation, and structural and cellular alterations of the synovial membrane.
Alexandra Damerau +7 more
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Risk Management and Healthcare Policy, 2023 Xiaoyi Li,1,* Zhen Zeng,2,* Xingying Fan,1,3 Wenju Wang,4 Xiaobo Luo,4 Junli Yang,1 Yue Chang1,3,* 1School of Medicine and Health Management, Guizhou Medical University, Guiyang, Guizhou Province, People’s Republic of China; 2Second ...
Li X +6 more
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Scientific Reports, 2017 Chronic administration of glucocorticoids has been shown to render individuals highly susceptible to mycobacterial infection and lead to reactivation of latent bacilli.
Jinli Wang +7 more
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Tissue-Specific Actions of Glucocorticoids on Apoptosis: A Double-Edged Sword
Cells, 2013 First described for their metabolic and immunosuppressive effects, glucocorticoids are widely prescribed in clinical settings of inflammation. However, glucocorticoids are also potent inducers of apoptosis in many cell types and tissues. This review will
Amanda L. Gruver-Yates +1 more
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Bad to the Bone: The Effects of Therapeutic Glucocorticoids on Osteoblasts and Osteocytes
Frontiers in Endocrinology, 2022 Despite the continued development of specialized immunosuppressive therapies in the form of monoclonal antibodies, glucocorticoids remain a mainstay in the treatment of rheumatological and auto-inflammatory disorders.
Manuel Gado +8 more
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Extra-adrenal regeneration of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1:physiological regulator and pharmacological target for energy partitioning [PDF]
, 2007 The major glucocorticoid in man, cortisol, plays important roles in regulating fuel metabolism, energy partitioning and body fat distribution.
Walker, Brian R
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