Results 31 to 40 of about 173,033 (308)

Glucocorticoid-induced osteoporosis – a disorder of mesenchymal stromal cells?

Frontiers in Endocrinology, 2011
Glucocorticoids are a class of steroid hormones that are essential to life but cause serious harm in excess. The main clinical features of glucocorticoid excess are due to adverse effects on cells and tissues that arise from a common developmental ...
Mark Stuart Cooper, Rowan eHardy
doaj   +1 more source

Improvement of Treg immune response after treatment with tocilizumab in giant cell arteritis

Clinical & Translational Immunology, 2021
Objectives To study the percentage, suppressive function and plasticity of Treg in giant cell arteritis (GCA), and the effects of glucocorticoids and tocilizumab.
Maxime Samson, Hélène Greigert, Marion Ciudad, Claire Gerard, Thibault Ghesquière, Malika Trad, Marc Corbera‐Bellalta, Coraline Genet, Sethi Ouandji, Claudie Cladière, Marine Thebault, Kim Heang Ly, Eric Liozon, François Maurier, Boris Bienvenu, Benjamin Terrier, Loïc Guillevin, Pierre Charles, Valérie Quipourt, Hervé Devilliers, Pierre‐Henry Gabrielle, Catherine Creuzot‐Garcher, Georges Tarris, Laurent Martin, Philippe Saas, Sylvain Audia, Maria Cinta Cid, Bernard Bonnotte   +27 more
doaj   +1 more source

Single-Cell Resolution and Quantitation of Targeted Glucocorticoid Delivery in the Thymus

Cell Reports, 2019
Summary: Glucocorticoids are lipid-soluble hormones that signal via the glucocorticoid receptor (GR), a ligand-dependent transcription factor. Circulating glucocorticoids derive from the adrenals, but it is now apparent that paracrine glucocorticoid ...
Matthew D. Taves, Paul R. Mittelstadt, Diego M. Presman, Gordon L. Hager, Jonathan D. Ashwell   +4 more
doaj   +1 more source

Glucocorticoids and resilience [PDF]

Hormones and Behavior, 2019
All organisms endure frequent challenges to homeostasis, or stressors, that require adaptation. Depending on the individual, the context, and the magnitude of stress, this active adaptation can lead to behavioral susceptibility or resilience. The latter is an under-appreciated consequence of stress, as the damaging effects of chronic stress and ...
Joanna L, Spencer-Segal, Huda, Akil
openaire   +2 more sources

Fibrotic pathways and fibroblast-like synoviocyte phenotypes in osteoarthritis

Frontiers in Immunology
Osteoarthritis (OA) is the most common form of arthritis, characterized by osteophyte formation, cartilage degradation, and structural and cellular alterations of the synovial membrane.
Alexandra Damerau, Alexandra Damerau, Emely Rosenow, Dana Alkhoury, Frank Buttgereit, Frank Buttgereit, Timo Gaber, Timo Gaber   +7 more
doaj   +1 more source

Trends and Patterns of Systemic Glucocorticoid Prescription in Primary Care Institutions in Southwest China, from 2018 to 2021

Risk Management and Healthcare Policy, 2023
Xiaoyi Li,1,* Zhen Zeng,2,* Xingying Fan,1,3 Wenju Wang,4 Xiaobo Luo,4 Junli Yang,1 Yue Chang1,3,* 1School of Medicine and Health Management, Guizhou Medical University, Guiyang, Guizhou Province, People’s Republic of China; 2Second ...
Li X, Zeng Z, Fan X, Wang W, Luo X, Yang J, Chang Y   +6 more
doaj  

Glucocorticoids Suppress Antimicrobial Autophagy and Nitric Oxide Production and Facilitate Mycobacterial Survival in Macrophages

Scientific Reports, 2017
Chronic administration of glucocorticoids has been shown to render individuals highly susceptible to mycobacterial infection and lead to reactivation of latent bacilli.
Jinli Wang, Ruining Wang, Hui Wang, Xiaofan Yang, Jiahui Yang, Wenjing Xiong, Qian Wen, Li Ma   +7 more
doaj   +1 more source

Bad to the Bone: The Effects of Therapeutic Glucocorticoids on Osteoblasts and Osteocytes

Frontiers in Endocrinology, 2022
Despite the continued development of specialized immunosuppressive therapies in the form of monoclonal antibodies, glucocorticoids remain a mainstay in the treatment of rheumatological and auto-inflammatory disorders.
Manuel Gado, Ulrike Baschant, Ulrike Baschant, Lorenz C. Hofbauer, Lorenz C. Hofbauer, Lorenz C. Hofbauer, Holger Henneicke, Holger Henneicke, Holger Henneicke   +8 more
doaj   +1 more source

Glucocorticoids [PDF]

, 2010
Оглядова стаття присвячена фізіологічною дією природних глюкокортикоїдів, причин розвитку дисфункції глюкокортикоїдів на системному і реґіонарному рівнях.
Килесса, В.В.
core   +5 more sources

Life Course Impact of Glucocorticoids During Pregnancy on Muscle Development and Function

Frontiers in Animal Science, 2021
Maternal stress, such as maternal obesity, can induce severe gestational disease and hormonal disorder which may disrupt fetal organ maturation and further cause endangered early or future health in offspring.
Yang Liu, Qiyue Ding, Wei Guo
doaj   +1 more source