Results 41 to 50 of about 393,042 (353)

Glucocorticoids Suppress Antimicrobial Autophagy and Nitric Oxide Production and Facilitate Mycobacterial Survival in Macrophages

Scientific Reports, 2017
Chronic administration of glucocorticoids has been shown to render individuals highly susceptible to mycobacterial infection and lead to reactivation of latent bacilli.
Jinli Wang, Ruining Wang, Hui Wang, Xiaofan Yang, Jiahui Yang, Wenjing Xiong, Qian Wen, Li Ma   +7 more
doaj   +1 more source

High‐dose glucocorticoids for the treatment of ipilimumab‐induced hypophysitis is associated with reduced survival in patients with melanoma

Cancer, 2018
It remains unclear whether high doses of glucocorticoids have a negative impact on the efficacy of checkpoint inhibitors. To control for the potential association between immune‐related adverse events (irAEs) and improved survival, this study examined a ...
A. Faje, D. Lawrence, K. Flaherty, C. Freedman, Riley M. Fadden, Krista M. Rubin, J. Cohen, R. Sullivan   +7 more
semanticscholar   +1 more source

A novel human glucocorticoid receptor SNP results in increased transactivation potential. [PDF]

, 2017
Glucocorticoids are one of the most widely used therapeutics in the treatment of a variety of inflammatory disorders. However, it is known that there are variable patient responses to glucocorticoid treatment; there are responders and non-responders, or ...
Cho, Kiho, Green, Tajia L, Greenhalgh, David G, Leventhal, Stacey M, Lim, Debora, Tung, Kelly   +5 more
core   +3 more sources

Trends and Patterns of Systemic Glucocorticoid Prescription in Primary Care Institutions in Southwest China, from 2018 to 2021

Risk Management and Healthcare Policy, 2023
Xiaoyi Li,1,* Zhen Zeng,2,* Xingying Fan,1,3 Wenju Wang,4 Xiaobo Luo,4 Junli Yang,1 Yue Chang1,3,* 1School of Medicine and Health Management, Guizhou Medical University, Guiyang, Guizhou Province, People’s Republic of China; 2Second ...
Li X, Zeng Z, Fan X, Wang W, Luo X, Yang J, Chang Y   +6 more
doaj  

Tissue-Specific Actions of Glucocorticoids on Apoptosis: A Double-Edged Sword

Cells, 2013
First described for their metabolic and immunosuppressive effects, glucocorticoids are widely prescribed in clinical settings of inflammation. However, glucocorticoids are also potent inducers of apoptosis in many cell types and tissues. This review will
Amanda L. Gruver-Yates, John A. Cidlowski   +1 more
doaj   +1 more source

Neuroenhancement of exposure therapy in anxiety disorders [PDF]

, 2015
Although exposure-based treatments and anxiolytic medications are more effective than placebo for treating anxiety disorders, there is still considerable room for further improvement.
Curtiss, Joshua, Hofmann, Stefan G., Mundy, Elizabeth A.   +2 more
core   +2 more sources

Glucocorticoid-Remediable Aldosteronism [PDF]

Cardiology in Review, 2004
Glucocorticoid-remediable aldosteronism (GRA) is a monogenic form of human hypertension that predisposes to cerebral hemorrhage. As a result of a chimeric gene duplication, aldosterone is ectopically synthesized in the cortisol-secreting zona fasciculata of the adrenal gland under the control of adrenocorticotropin (ACTH).
Graham T, McMahon, Robert G, Dluhy
openaire   +3 more sources

Changes in adenosine 5'-monophosphate-activated protein kinase as a mechanism of visceral obesity in Cushing's syndrome [PDF]

, 2008
OBJECTIVE: Features of the metabolic syndrome such as central obesity with insulin resistance and dyslipidemia are typical signs of Cushing's syndrome and common side effects of prolonged glucocorticoid treatment.
Blerina Kola, Mirjam Christ-Crain, Francesca Lolli, Giorgio Arnaldi, Gilberta Giacchetti, Marco Boscaro, Ashley B. Grossman, Márta Korbonits, Kola, Gudbjornsson, van Staa, Walsh, Arnaldi, Mayo-Smith, Kahn, Christ-Crain, Tataranni, Steinberg, Hojlund, Bandyopadhyay, Kola, Hawley, Terzolo, Mantero, Barzon, Bujalska, Seckl, Daval, Wang, Vander Kooi, Shaw, Clark   +31 more
core   +1 more source

Impacts of different methylprednisolone administration routes in patients with sudden hearing loss or Meniere’s disease

Journal of Otology, 2020
Background: Evidence suggests that glucocorticoids are important in the treatment of sudden hearing loss (SHL) and Meniere’s disease (MD). However, different glucocorticoid administration methods may have a significant impact on treatment outcomes ...
Dan Chen, Zhipeng Li, Qilin Zhou, Yubin Chen, Luoying Yang, Jingqian Tan, Xiangli Zeng, Peng Li   +7 more
doaj   +1 more source

Brief increases in corticosterone affect morphology, stress responses, and telomere length, but not post-fledging movements, in a wild songbird

, 2018
Organisms are frequently exposed to challenges during development, such as poor weather and food shortage. Such challenges can initiate the hormonal stress response, which involves secretion of glucocorticoids. Although the hormonal stress response helps
Haussmann, Mark F., Pegan, Teresa M., Vitousek, Maren N., Winkler, David W.   +3 more
core   +1 more source