Glucocorticoids act on glutamatergic pathways to affect memory processes [PDF]
, 2011 Glucocorticoids can acutely affect memory processes, with both facilitating and impairing effects having been described. Recent work has revealed that glucocorticoids may affect learning and memory processes by interacting with glutamatergic mechanisms ...
Sandi, Carmen, Sandi C, Carmen Sandi
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, 2012 As one class of the most important steroid hormones, glucocorticoids have long been recognised and their therapeutic benefits have been widely used in clinical treatment, especially in anti-inflammation cases.
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MicroRNA-146a is induced by inflammatory stimuli in airway epithelial cells and augments the anti-inflammatory effects of glucocorticoids. [PDF]
PLoS ONE, 2018 BACKGROUND:MicroRNAs (miRNAs) are emerging as central regulators of inflammation, but their role in asthma and airway epithelial cells is not well studied. Glucocorticoids are the cornerstone of therapy in asthma and other inflammatory disease, yet their
Kristin A Lambert +4 more
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Frontiers in Pharmacology, 2021 Aims: To explore the interactive influence of glucocorticoids and cytochrome P450 (CYP450) polymorphisms on voriconazole (VRC) plasma trough concentrations (Cmin) and provide a reliable basis for reasonable application of VRC.Methods: A total of 918 VRC ...
Su-jie Jia +13 more
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Dexamethasone-Induced Expression of Endothelial Mitogen-Activated Protein Kinase Phosphatase-1 Involves Activation of the Transcription Factors Activator Protein-1 and 3',5'-Cyclic Adenosine 5'-Monophosphate Response Element-Binding Protein and the Generation of Reactive Oxygen Species [PDF]
, 2008 We have recently identified the MAPK phosphatase (MKP)-1 as a novel mediator of the antiinflammatory properties of glucocorticoids (dexamethasone) in the human endothelium. However, nothing is as yet known about the signaling pathways responsible for the
Vollmar, Angelika M. +2 more
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Interleukin-10 Enhances the Intestinal Epithelial Barrier in the Presence of Corticosteroids through p38 MAPK Activity in Caco-2 Monolayers: A Possible Mechanism for Steroid Responsiveness in Ulcerative Colitis. [PDF]
PLoS ONE, 2015 Glucocorticosteroids are the first line therapy for moderate-severe flare-ups of ulcerative colitis. Despite that, up to 60% of patients do not respond adequately to steroid treatment.
Violeta Lorén +7 more
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Use of glucocorticoids in the management of immunotherapy‐related adverse effects
Thoracic Cancer, 2020 Immune checkpoint inhibitors (ICIs) activate host antitumor immunity to kill tumor cells. However, ICI therapy may be accompanied by a series of immunotherapy‐related adverse effects (irAEs) caused by activated autoreactive T cells.
Hanping Wang +6 more
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Scientific Reports, 2021 Glucocorticoids might have significant influence on positive fluid balance, mostly due to their mineralocorticoid effect. We assessed the association between glucocorticoid therapy and fluid balance in septic patients, in the intensive care unit (ICU ...
Amit Frenkel +7 more
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, 2010 Оглядова стаття присвячена фізіологічною дією природних глюкокортикоїдів, причин розвитку дисфункції глюкокортикоїдів на системному і реґіонарному рівнях.
Килесса, В.В.
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The influence of glucocorticoids on neuronal survival and synaptic function
Biomolecular Concepts, 2012 Glucocorticoids, recognized as stress-related steroid hormones secreted from adrenal glands, have multiple roles in brain function. The concentration of glucocorticoids is regulated by the hypothalamic-pituitary-adrenal axis, and chronically elevated ...
Numakawa Tadahiro +4 more
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