Results 11 to 20 of about 310,312 (350)
Regulation of Glucose Homeostasis by Glucocorticoids [PDF]
Advances in Experimental Medicine and Biology, 2015 Glucocorticoids are steroid hormones that regulate multiple aspects of glucose homeostasis. Glucocorticoids promote gluconeogenesis in liver, whereas in skeletal muscle and white adipose tissue they decrease glucose uptake and utilization by antagonizing
Wang, Jen-Chywan +7 more
core +2 more sources
Clinical evidence of an interferon–glucocorticoid therapeutic synergy in COVID-19
Signal Transduction and Targeted Therapy, 2021 Synthetic glucocorticoid dexamethasone is the first trial-proven drug that reduces COVID-19 mortality by suppressing immune system. In contrast, interferons are a crucial component of host antiviral immunity and can be directly suppressed by ...
Yingying Lu +11 more
doaj +1 more source
Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis
New England Journal of Medicine, 2020 BACKGROUND More effective and safer treatments are needed for antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis. METHODS We conducted a randomized trial with a 2-by-2 factorial design to evaluate the use of plasma exchange and two regimens
M. Walsh +34 more
semanticscholar +1 more source
Glucocorticoids in Sepsis: To Be or Not to Be
Frontiers in Immunology, 2020 Sepsis is a highly lethal syndrome resulting from dysregulated immune and metabolic responses to infection, thereby compromising host homeostasis. Activation of the hypothalamic-pituitary-adrenal (HPA) axis and subsequently adrenocortical glucocorticoid (GC) production during sepsis are important regulatory processes to maintain homeostasis.
Jolien Vandewalle +3 more
openaire +4 more sources
Intra-articular glucocorticoid injection site: best practice guidelines
Медицинский совет, 2021 The article presents modern recommendations for the use of systemic administration of glucocorticoids. It is indicated that there is a clear tendency to minimize the doses and timing of the appointment of systemic glucocorticoids in rheumatoid arthritis,
N. V. Chichasova, A. M. Lila
doaj +1 more source
Effects of different doses of glucocorticoids on postoperative atrial fibrillation: a meta-analysis
BMC Cardiovascular Disorders, 2023 Background Postoperative atrial fibrillation (POAF) is the most common arrhythmia after cardiac surgery, and its occurrence is closely related to inflammation. This paper intends to apply meta-analysis to investigate the effect of glucocorticoids on POAF.
Zhongzheng Zhou +3 more
doaj +1 more source
Frontiers in Immunology, 2021 BackgroundGlucocorticoid is one of the common and important strategies for the treatment of chimeric antigen receptor T (CAR-T) cell therapy-related toxicity.
Zhen Sun +4 more
doaj +1 more source
Glucocorticoids for human skin: New aspects of the mechanism of action [PDF]
, 2005 Topical glucocorticoids have always been considered first-line drugs for inflammatory diseases of the skin and bronchial system. Applied systemically, glucocorticoids are used for severe inflammatory and immunological diseases and the inhibition of ...
Korting, Hans Christian +4 more
core +1 more source
International Journal of Infectious Diseases, 2021 Background: Glucocorticoid therapy has emerged as an effective therapeutic option in hospitalized patients with coronavirus disease 2019 (COVID-19). This study aimed to focus on the impact of relevant clinical and laboratory factors on the protective ...
Matteo Pagnesi +39 more
doaj +1 more source
MAPK phosphatase-1 represents a novel antiinflammatory target of glucocorticoids in the human endothelium [PDF]
, 2007 Glucocorticoids are well-established anti- inflammatory drugs thought to mainly act by inhibition of proinflammatory transcription factors like NF-κB.
Timm Schroeder +20 more
core +1 more source