Results 71 to 80 of about 241,090 (306)

The NorthStar Ambulatory Assessment in Duchenne muscular dystrophy: considerations for the design of clinical trials [PDF]

, 2016
With the emergence of experimental therapies for Duchenne muscular dystrophy (DMD), it is fundamental to understand the natural history of this disorder to properly design clinical trials.
Main, M, Pane, M, Ricotti, V, Manzur, AY, on behalf of UK NorthStar Clinical Network, ., Muntoni, F, Ridout, DA, Mercuri, E, Mayhew, A, Toms B., Childs A., Roper, H., Pallant L., Toms, B, Messina, S, Chow, G, Palmer, J., White C., Sarkozy, A, McMurchie, H., Emery N., Bateman, E., Quinlivan, R, Groves L., Jungbluth, H., Keddie, A, Parsons, B., Senior M., Ridout, Deborah A., Shillington, A., Geary, M, Robb, S., Eagle, M, Childs, A, Mongini, T, Horrocks I., Spinty, S., Muntoni F., Sarkozy, A., Keddie A., Sheehan, J., De Goede C., Manzur, Adnan Y., Scott, E, Greenfield, K., Spahr, R, Willis, T, Wraige E., Mayhew, Anna, Pysden, K., Thomas, N., Bushby, K., Jenkins, L., Baxter, P, Hartley, L, Majumdar A., Thomas N., Robb, S, Pane, Marika, Bateman E., Willis T., Main, Marion, Pallant, L., Ridout D. A., Guglieri M., Roper, H, Pini, A, Robb S., Mercuri E., Wraige, E., Pallant, L, Groves, L., Chow, G., White, C, Jungbluth H., Majumdar, A, Bruno, C, Childs, A., Senior, M, Miah, A, Straub V., Battini, R, POLITANO, Luisa, Hartley L., MESSINA, Sonia, Cammiss, C, Bateman, E, Pysden K., Senior, M., Scott E., White, C., Muntoni, Francesco, Jenkins L., McMurchie H., Eagle, M., Peachey G., Peachey, G., Chow G., Bushby, K, Guglieri, M, Miah, A., Di Marco, M, Miah A., de Goede, C, Greenfield K., Butler, J., Hartley, L., Horrocks, I., Jenkins, L, Cammiss C., Hughes, I., Straub, V, Parsons B., Baxter, P., Bushby K., Cammiss, C., Parsons, B, Pane M., Greenfield, K, Keddie, A., Mercuri, Eugenio, Mayhew A., Hughes I., Naismith, K., Pysden, K, Roper H., D'Amico, A, Mcmurchie, H, Emery, N, Scott, E., Jungbluth, H, Toms, B., Ricotti, Valeria, Di Marco M., Spahr R., Butler J., Shillington, A, Wilson I., Geary, M., Quinlivan R., Groves, L, De Goede, C., Quinlivan, R., Butler, J, Manzur A. Y., Emery, N., Willis, T., Horrocks, I, Spahr, R., Di Marco, M., Hughes, I, Bertini, E, Peachey, G, Morandi, L., Shillington A., Spinty S., Main M., Spinty, S, Pegoraro, E, Naismith, K, Eagle M., Wilson, I., Palmer, J, Sheehan J., Baxter P., Guglieri, M., Comi, G, Sarkozy A., Ricotti V., Wilson, I, Naismith K., Thomas, N, Berardinelli, A, Wraige, E, Geary M., Sheehan, J, Palmer J., Straub, V., Majumdar, A.   +178 more
core   +1 more source

Associations between glucocorticoids and habitat selection reflect daily and seasonal energy requirements

Movement Ecology
Background Glucocorticoids are often associated with stressful environments, but they are also thought to drive the best strategies to improve fitness in stressful environments. Glucocorticoids improve fitness in part by regulating foraging behaviours in
Levi Newediuk, Gabriela F. Mastromonaco, Eric Vander Wal   +2 more
doaj   +1 more source

Clinician and Patient Factors Associated With Long‐Term Glucocorticoid Use in People With Rheumatoid Arthritis Receiving Advanced Therapies

Arthritis Care &Research, EarlyView.
Objective Despite guideline recommendations, long‐term glucocorticoid (GC) use is common in rheumatoid arthritis (RA). We conducted a clinician survey nested within a large registry to identify patient and clinician factors associated with GC use. Methods Clinicians contributing patients to the CorEvitas Rheumatoid Arthritis Registry were surveyed ...
Michael D. George, George Reed, Matthew D. Kearney, Peter F. Cronholm, Kevin Kane, Jeffrey R. Curtis, Dimitrios A. Pappas, Joel M. Kremer   +7 more
wiley   +1 more source

Short‐Term Response to Biologic Therapy in Psoriatic Arthritis Is Not Influenced by Disease Duration at Initiation of Therapy

Arthritis Care &Research, EarlyView.
Objective We aimed to determine whether the short‐term response to biologics in biologic‐naive psoriatic arthritis (PsA) is better in patients initiating biologic treatment early in the disease course. Methods Patients with PsA who started on biologic therapy from the year 2000 to 2025 were included for analysis.
Sung Min Cho, Shangyi Gao, Daniel Pereira, Richard J. Cook, Dafna D. Gladman   +4 more
wiley   +1 more source

Nongenomic Effects of Glucocorticoids, an Important Mechanism of Inhaled Glucocorticoids Action in Asthma

, 2009
Authors describe the clinical implications of nongenomic effects of glucocorticoids, important also for the inhaled drugs. Data suggest that these rapid actions of glucocorticoids are important in the pharmacotherapy of asthma, particularly for ...
Alicja Grzanka, Jerzy Jarząb
core   +1 more source

Glucocorticoids in Poison Frogs

, 2023
Data on glucocorticoids present in water samples collected from 5 different species of poison frogs. Glucocorticoid release rate data from ACTH challenges on adult Dendrobates tinctorius. 
Sarah Westrick (7573355)
core   +1 more source

Employment Trajectories of Patients With Systemic Lupus Erythematosus and Factors Driving Transitions Between States

Arthritis Care &Research, EarlyView.
Objective Systemic lupus erythematosus (SLE) significantly impacts employment capacity. This study aimed to investigate the impact of burden of disease activity, damage, and treatment on employment outcomes and transitions in patients with SLE. Methods Using data from a single center, we analyzed employment transitions, adjusted mean disease activity ...
Javier Mencia‐Ledo, Zahi Touma, Laura Whittall Garcia, Dafna D. Gladman, Behdin Nowrouzi‐Kia   +4 more
wiley   +1 more source

Glucocorticoids Regulate the Vascular Remodeling of Aortic Dissection Via the p38 MAPK-HSP27 Pathway Mediated by Soluble TNF-RII

EBioMedicine, 2018
Increasing researches suggest that inflammatory response is involved in vascular remodeling, which plays an important role in the development of aortic dissection.
Lei Zhang, Jian Zhou, Zaiping Jing, Yu Xiao, Yudong Sun, Yani Wu, Huiying Sun   +6 more
doaj   +1 more source

Optimizing Hydroxychloroquine Blood Levels and Long‐Term Hydroxychloroquine Intake Could Lower Atherosclerotic Cardiovascular Disease Risk and Prevent Polypharmacy in Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective Hydroxychloroquine (HCQ) is the cornerstone of systemic lupus erythematosus (SLE) management with benefits extending beyond SLE control, including protection against atherosclerotic cardiovascular disease (ASCVD). Although HCQ blood levels reflect recent exposure and long‐term intake reflects medication adherence, the impact of longitudinal ...
Shivani Garg, Murray Urowitz, Charlie Dentz, Niriti Adhikari, Fauzia Hollnagel, Nathalie Costedoat‐Chalumeau   +5 more
wiley   +1 more source

Glucocorticoids modulate TGF-β production

, 2002
TGF-beta is thought to play a central role in pulmonary fibrosis inducing fibroblast differentiation and extracellular matrix synthesis. In human lung fibroblasts, it is still unclear how various TGB-beta isoforms affect TGF-beta production and whether ...
Liu, X, Rennard, Stephen I., Stoner, Julie A., Zhu, YK, Liu, Xiangde, Romberger, Debra J., Stoner, J, Kohyama, T, Wen, Fu Qiang, Rennard, SI, Zhu, Yun Kiu, Sköld, C. Magnus, Romberger, DJ, Wen, F-Q, Kohyama, Tadashi, Sköld, CM   +15 more
core   +1 more source