Results 91 to 100 of about 241,090 (306)

Patients improve, patterns persist: longitudinal stability of RA joint involvement patterns

open access: yesArthritis Care &Research, Accepted Article.
Objective Rheumatoid arthritis is a heterogeneous disease. Data‐driven approaches, from synovial histology to joint involvement patterns (JIPs), have sought to define clinically meaningful subgroups. Whether these subgroups represent stable phenotypes or transient disease states remains unclear.
Tjardo Maarseveen   +24 more
wiley   +1 more source

Endogenous and Exogenous Glucocorticoids in Obesity and Stress-Related Diseases [PDF]

open access: yes, 2021
Glucocorticoids, also known as stress hormones, are essential for survival and for physical and mental adaptation to changing situations. Too much glucocorticoids can however yield a variety of symptoms and comorbidities.
Savas, M. (Mesut)
core  

Glucocorticoids ameliorate TGF-β1-mediated epithelial-to-mesenchymal transition of airway epithelium through MAPK and Snail/Slug signaling pathways

open access: yesScientific Reports, 2017
Chronic rhinosinusitis with nasal polyps (CRSwNP) is closely associated with tissue remodeling. Epithelial-to-mesenchymal transition (EMT), a process of tissue remodeling, can be a therapeutic target of CRSwNP.
Hyun-Woo Yang   +4 more
doaj   +1 more source

Regulation of stem cell factor expression in inflammation and asthma

open access: yesMemorias do Instituto Oswaldo Cruz, 2005
Stem cell factor (SCF) is a major mast cell growth factor, which could be involved in the local increase of mast cell number in the asthmatic airways.
Carla A Da Silva, Nelly Frossard
doaj   +1 more source

Positive Affect Is Associated With Better Physical Function in Early Rheumatoid Arthritis

open access: yesArthritis Care &Research, EarlyView.
Objective This study examined the association between positive affect and physical function in individuals with early rheumatoid arthritis (RA). Methods We analyzed baseline data from 129 adults with early RA (persistent joint symptoms for ≤24 months) and active disease enrolled in the Central Pain in RA 2 (CPIRA‐2) study.
Burcu Aydemir   +9 more
wiley   +1 more source

The Stressed CNS: When Glucocorticoids Aggravate Inflammation

open access: yes, 2009
Glucocorticoids (GCs) are hormones released during the stress response that are well known for their immunosuppressive and anti-inflammatory properties; however, recent advances have uncovered situations wherein they have effects in the opposite ...
Robert M. Sapolsky   +7 more
core   +1 more source

Glucocorticoids and angiogenesis [PDF]

open access: yes, 2005
Angiogenesis is the creation of new blood vessels from the existing vasculature that occurs through a complex series of interactions and is tightly regulated.
Small, Gary Robert
core   +1 more source

Generative AI in clinical practice: how should rheumatologists evaluate and monitor emerging tools?

open access: yesArthritis Care &Research, Accepted Article.
Generative artificial intelligence (AI) is increasingly being used in rheumatology practice, to assist with tasks such as documentation, record summarization, and clinical decision support. Rheumatologists need a practical approach to determining what evidence and oversight each application requires.
Koushan Kouranloo   +2 more
wiley   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

open access: yesAdvanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou   +6 more
wiley   +1 more source

Glucocorticoids induced allergic reaction [PDF]

open access: yes, 2013
Glucocorticoids can cause allergic reaction in rare cases. A ten year old boy, known asthmatic, was treated with intramuscular injection of glucocorticoids, followed by nausea, vomiting and abdominal pain.
Ahmed, Shakeel, Siddiqui, Emad Uddin
core  

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