Results 91 to 100 of about 173,033 (308)

Glucocorticoids and Obesity [PDF]

open access: yes, 2018
Glucocorticoids are a class of hormones which affect virtually every aspect of physiology, including metabolism, behavior and immunity. The most important glucocorticoid in humans is cortisol.
Wester, Vincent, Wester, V.L. (Vincent)
core  

Assessing the Sensitivity and the Clinical Impact of the 2023 American College of Rheumatology/EULAR Classification Criteria in Obstetric Antiphospholid Syndrome: Findings From a Multicenter Italian Cohort With a Long‐Term Follow‐Up

open access: yesArthritis Care &Research, EarlyView.
Objective The aim of this study was to evaluate the sensitivity of the 2023 American College of Rheumatology (ACR)/EULAR classification criteria for antiphospholipid syndrome (APS) in a real‐world cohort of women diagnosed with primary obstetric APS (oAPS) and to assess their ability to identify patients at risk of future pregnancy complications ...
Francesca Ruffilli   +10 more
wiley   +1 more source

Regulation of CYP3A genes by glucocorticoids in human lung cells [v2; ref status: indexed, http://f1000r.es/1z6]

open access: yesF1000Research, 2013
Inhaled glucocorticoids are the first-line treatment for patients with persistent asthma.  However, approximately thirty percent of patients exhibit glucocorticoid insensitivity, which may involve excess metabolic clearance of the glucocorticoids by ...
Jessica K Roberts   +5 more
doaj   +1 more source

Cumulative Social Disadvantage and Disease Activity in Juvenile Idiopathic Arthritis: A Childhood Arthritis and Rheumatology Research Alliance Registry Study

open access: yesArthritis Care &Research, EarlyView.
Objective Social determinants of health (SDOH) contribute to juvenile idiopathic arthritis (JIA) disparities, but most studies have assessed SDOH independently rather than cumulatively across individual, family, and neighborhood levels. Using a socioecological framework, we investigated the relationship among cumulative social disadvantage ...
William Daniel Soulsby   +448 more
wiley   +1 more source

The role of endogenous annexin A1 on leukocyte biology [PDF]

open access: yes, 2005
PhDInflammation is the body's innate immune response to the damage caused to its cells and vascularised tissue, either by injury or microbial pathogens.
Yona, Simon
core  

Glucocorticoids modulate TGF-β production [PDF]

open access: yes, 2002
TGF-beta is thought to play a central role in pulmonary fibrosis inducing fibroblast differentiation and extracellular matrix synthesis. In human lung fibroblasts, it is still unclear how various TGB-beta isoforms affect TGF-beta production and whether ...
Liu, X   +15 more
core   +1 more source

Comparative Efficacy and Safety of Medical Treatments for IgG4-Related Disease: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials

open access: yesJournal of Clinical Question
Introduction: IgG4-related disease (IgG4-RD) is a chronic, immune-mediated fibroinflammatory disorder commonly treated with glucocorticoids; however, relapse and steroid-related toxicity remain major challenges.
Rui Zhang   +3 more
doaj   +1 more source

The Association of Physical Function With Psychosocial Patient‐Reported Outcomes in People With Systemic Lupus Erythematosus

open access: yesArthritis Care &Research, EarlyView.
Objective To evaluate how modifiable psychosocial factors and fatigue relate to physical functioning in patients with systemic lupus erythematosus (SLE). Methods In this cross‐sectional study of two demographically distinct cohorts (Approaches to Positive, Patient‐Centered Experiences of Aging with Lupus [APPEAL] and California Lupus Epidemiology Study
Mrinalini Dey   +8 more
wiley   +1 more source

Glucocorticoids, chronic stress, and obesity [PDF]

open access: yes, 2006
Glucocorticoids either inhibit or sensitize stress-induced activity in the hypothalamo-pituitary-adrenal (HPA) axis, depending on time after their administration, the concentration of the steroids, and whether there is a concurrent stressor input.
Ginsberg, Abigail B.   +21 more
core   +1 more source

Glucocorticoid Resistance

open access: yes, 2019
Primary generalized glucocorticoid resistance or Chrousos syndrome is a rare disorder, which affects all tissues expressing the human glucocorticoid receptor. It is characterized by generalized, partial tissue insensitivity to glucocorticoids caused by genetic defects in the NR3C1 gene.
Nicolaides, N.C., Charmandari, E.
openaire   +3 more sources

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