Results 81 to 90 of about 393,042 (353)

Sarilumab in Polyarticular‐Course Juvenile Idiopathic Arthritis: Dose‐Finding and 1‐Year Analysis of a Phase 2b, Open‐Label, Multicenter Study

Arthritis Care &Research, EarlyView.
Objective This study assessed sarilumab in treating patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods This phase 2b, open‐label study (NCT02776735) consisted of three sequential parts (each with a core‐treatment and extension phase).
Fabrizio De Benedetti, Inmaculada C. Penadés, Irina Nikishina, Ivan Foeldvari, Alberto J. Spindler, Anna Kozlova, Nadina Rubio‐Pérez, Pierre Quartier, Zbigniew Żuber, Raul Barria, Daniel Clemente, Gabriel V. Cornejo, Katherine Marzan, Nancy Liu, Christine Xu, Stephen DiMartino, Angeliki Giannelou, Fei Cao‐Ghoul, Bolanle Akinlade, Lydie Baret‐Cormel   +19 more
wiley   +1 more source

Glycometabolic Alterations in Secondary Adrenal Insufficiency: Does Replacement Therapy Play a Role? [PDF]

, 2018
Secondary adrenal insufficiency (SAI) is a potentially life-threatening endocrine disorder due to an impairment of corticotropin (ACTH) secretion from any process affecting the hypothalamus or pituitary gland.
Gianfrilli, Daniele, Graziadio, Chiara, Hasenmajer, Valeria, Isidori, Andrea M., Sbardella, Emilia, Venneri, Mary A.   +5 more
core   +6 more sources

Postoperative glucocorticoids in patients with acute type A aortic dissection (GLAD): study protocol for a prospective, single-center, randomized controlled trial

BMC Anesthesiology, 2023
Background Patients receiving surgical treatment of acute type A Aortic Dissection (aTAAD) are common to suffer organ dysfunction in the intensive care unit due to overwhelming inflammation.
Yi-zhi Deng, Ming-hao Luo, Jing-chao Luo, Jia-kun Li, Jia-qi Chen, Yi-jie Zhang, Jun-yi Hou, Ying Su, Guo-wei Tu, Zhe Luo   +9 more
doaj   +1 more source

Evaluation of glucocorticoids utilization in central kerala using pharmacy sales overview

Indian Journal of Endocrinology and Metabolism, 2021
Background: Misuse of prescription drugs is a major public health problem in India and developing countries. Emerging evidence indicates that glucocorticoids are a class of drugs that are silently misused. These drugs are inexpensive and easily available
Sara Mathew, Philip Finny, Abel K Samuel Johnson, Mridula Maria, Preethy S Samuel, Lois J Armstrong, Alice David   +6 more
doaj   +1 more source

A Qualitative Analysis of Patient Perspectives and Preferences in Lupus Management to Guide Lupus Guidelines Development

Arthritis Care &Research, EarlyView.
Objective A patient‐centered approach for chronic disease management, including systemic lupus erythematosus (SLE), aligns treatment with patients’ values and preferences, leading to improved outcomes. This paper summarizes how patient experiences, perspectives, and priorities informed the American College of Rheumatology (ACR) 2024 Lupus Nephritis (LN)
Shivani Garg, Izzy Hartel, Lisa R. Sammaritano, Anca Askanase, Bonnie L. Bermas, Maria Dall'Era, Alí Duarte‐García, Victoria P. Werth, Brad Rovin, Reem A. Mustafa, Amy S. Turner, Bené Williams, Brian L. Ung, Hiya Bhavsar, Monique C. Gore‐Massy, Nahirannette Pulido, Natacha Guerrero, Natalie M. Smith, Wambui Machua, Linda T. Hiraki, Mary Beth Son   +20 more
wiley   +1 more source

Application of glucocorticoids in oral mucosal diseases [PDF]

Kouqiang yixue
Glucocorticoids possess potent anti-inflammatory and immunosuppressive properties, rendering them a common therapeutic option for oral mucosal diseases.
YING Minqian, LI Kaiyue, LIU Chuanxia
doaj   +1 more source

Adrenal crises: perspectives and research directions [PDF]

, 2017
Adrenal crises (AC) are life-threatening complications of adrenal insufficiency (AI). These events have an estimated incidence of between 5 and 10 ACs/100 patient years (PY) and are responsible for some of the increased morbidity and excess mortality ...
Falhammar, H, Rushworth, R, Torpy, D
core   +2 more sources

Performance Characteristics of Anti–Collagen II Antibodies in Relapsing Polychondritis and Related Diseases: Prospective Analysis, Systematic Review, and Meta‐Analysis

Arthritis Care &Research, EarlyView.
Objective Relapsing polychondritis (RP) is a rare disease defined by recurrent cartilaginous inflammation. Anti–collagen II (Col2) antibodies have been proposed as a diagnostic biomarker for RP, but their performance characteristics are not well defined.
Karyssa Stonick, Marcela A. Ferrada, Alice Fike, Kaitlin A. Quinn, Benjamin A. Turturice, Casey Stein, Peter C Grayson   +6 more
wiley   +1 more source

Systematic review of the clinical effect of glucocorticoids on nonhematologic malignancy

BMC Cancer, 2008
Background Glucocorticoids are often used in the treatment of nonhematologic malignancy. This review summarizes the clinical evidence of the effect of glucocorticoid therapy on nonhematologic malignancy. Methods A systematic review of clinical studies of
Keith Bruce D
doaj   +1 more source

The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids

Endocrine reviews, 2016
ESSENTIAL POINTS The daily rhythmicity of plasma glucocorticoid (GC) levels is a strong modulator of many physiological and psychological processes, although its functional significance is poorly understood.
H. Oster, E. Challet, Volker Ott, E. Arvat, E. de Kloet, D. Dijk, S. Lightman, A. Vgontzas, E. van Cauter   +8 more
semanticscholar   +1 more source