Results 111 to 120 of about 241,090 (306)
Advanced Science, EarlyView.Under normal conditions, MACF1 interacts with Rab14 and facilitates KIF16B‐mediated FGFR vesicle trafficking along microtubules to the plasma membrane, thereby supporting BMSC differentiation. In contrast, chronic GC exposure suppresses MACF1 expression, disrupting this transport and causing intracellular FGFR retention, which blunts osteogenic ...
Peihong Su +14 more
wiley +1 more source
Advanced Science, EarlyView.This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan +6 more
wiley +1 more source
New dimension of glucocorticoids in cancer treatment
, 2016 [[abstract]]Glucocorticoids have been used in clinical oncology for over half of the century. The clinical applications of glucocorticoids in oncology are mainly dependent on their pro-apoptotic action to treat lymphoproliferative disorders, and also on ...
Lin, KT;Wang, LH
core +1 more source
Advanced Science, EarlyView.Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo +10 more
wiley +1 more source
Exogenous glucocorticoids and adverse cerebral effects in children
, 2011 Glucocorticoids are commonly used in treatment of paediatric diseases, but evidence of associated adverse cerebral effects is accumulating. The various pharmacokinetic profiles of the exogenous glucocorticoids and the changes in pharmacodynamics during ...
Paulson, Olaf B +7 more
core +1 more source
Advanced Science, EarlyView.Glucocorticoids transcriptionally activate LCN2 expression via GR nuclear translocation. Secreted LCN2 binds MMP9 to degrade skeletal muscle ECM collagen, blocks integrin‐mediated mechanotransduction, bidirectionally disrupts muscle protein homeostasis, and reveals a novel target for steroid‐induced muscle atrophy.
Hongwei Shi +11 more
wiley +1 more source
New glucocorticoids on the horizon: Repress, don't activate!
, 2005 Glucocorticoids are highly effective drugs; their immunosuppressive and antiinflammatory actions are used in the treatment of many rheumatic and other inflammatory diseases.
Buttgereit, F. +4 more
core +1 more source
Proceedings: The Many Facets of Glucocorticoid Actions from Stress and Beyond
Poultry ScienceSummary: Glucocorticoids have many physiological functions and the stress response is just one of them. However, in much of poultry science, glucocorticoids are considered solely as stress hormones and that assumption may lead to an unintentional ...
G. Bédéccarrats +5 more
doaj +1 more source
Advanced Science, EarlyView.Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang +12 more
wiley +1 more source
Steroidal antiinflammatory drugs: glucocorticoids [PDF]
Einstein (São Paulo), 2008 Glucocorticoids are largely used drugs because of theirimmunosuppressive and anti-infl ammatory effects in the treatment ofmany rheumatic and other infl ammatory diseases. However, their useis sometimes limited by numerous adverse reactions.
Sônia Maria Alvarenga Anti +2 more
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