Results 131 to 140 of about 162,740 (383)

Gluconeogenesis and risk for fasting hyperglycemia in Black and White women.

JCI Insight, 2018
Black women, compared with White women, have high rates of whole-body insulin resistance but a lower prevalence of fasting hyperglycemia and hepatic steatosis. This dissociation of whole-body insulin resistance from fasting hyperglycemia may be explained
Stephanie T Chung, Amber B Courville, Anthony U Onuzuruike, Mirella Galvan-De La Cruz, Lilian S. Mabundo, Christopher W Dubose, Kannan Kasturi, H. Cai, A. Gharib, Peter J. Walter, H. Martin Garraffo, S. Chacko, Morey W. Haymond, Anne E Sumner   +13 more
semanticscholar   +1 more source

A Drosophila model of prion disease and its metabolic changes in the brain

Animal Models and Experimental Medicine, EarlyView.
We developed a Drosophila model for prion disease, and flies were capable of expressing the hamster prion protein (HaPrP) under the control of the GAL4/UAS system. The model exhibited some characteristics of the disease in mammals and displayed alterations in protein, sphingolipid, and carbohydrate metabolism. Preliminary applications have demonstrated
Dongdong Wang, Zhixin Sun, Pei Wen, Mengyang Zhao, Yuheng He, Fengting Gou, Jingjing Wang, Qing Fan, Xueyuan Li, Tianying Ma, Xiaoyu Wang, Wen Li, Sen Chen, Deming Zhao, Lifeng Yang   +14 more
wiley   +1 more source

The promoter polymorphism -232C/G of the PCK1 gene is associated with type 2 diabetes in a UK-resident South Asian population [PDF]

, 2009
Background: The PCK1 gene, encoding cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C), has previously been implicated as a candidate gene for type 2 diabetes (T2D) susceptibility.
A Valera, Abigail C Britten, AG Gomez-Valades, AH Barnett, Anthony H Barnett, BF Voight, CJ Willer, EG Beale, EH Hani, H Cao, H Zouali, HD Shin, I Gouni-Berthold, J Paul O'Hare, JC Barrett, L Wegner, M Ann Kelly, S Bellary, S Purcell, SD Rees, Simon D Rees, Srikanth Bellary, Sudhesh Kumar, The International HapMap Consortium, Y Dong   +24 more
core   +6 more sources

TGF-β1/Smad3 Pathway Targets PP2A-AMPK-FoxO1 Signaling to Regulate Hepatic Gluconeogenesis*

Journal of Biological Chemistry, 2017
Maintenance of glucose homeostasis is essential for normal physiology. Deviation from normal glucose levels, in either direction, increases susceptibility to serious medical complications such as hypoglycemia and diabetes.
H. Yadav, Samir Devalaraja, S. Chung, S. Rane   +3 more
semanticscholar   +1 more source

Growth Hormone Promotes Lipolysis and Impairs Insulin Sensitivity by Activating the ERK/HSL Signaling Pathway in Bovine Adipocytes

Animal Research and One Health, EarlyView.
This study was to evaluate the role of GH in lipolysis and insulin sensitivity in bovine adipocytes and clarify the underlying mechanism. Our findings demonstrate that GH activates ERK/HSL signaling pathway, promotes lipolysis, and impairs insulin sensitivity in bovine adipocytes.
Xinxing Gao, Hao Yu, Erminio Trevisi, Cai Lin, Zhiyuan Fang, Xinwei Li, Yuxiang Song, Wenwen Gao, Lin Lei, Xiliang Du, Guowen Liu   +10 more
wiley   +1 more source

CPS1 augments hepatic glucagon response through CaMKII/FOXO1 pathway

Frontiers in Pharmacology
Introduction: Elevated glucagon levels are a characteristic feature of type 2 diabetes. This abnormal increase in glucagon can lead to an accelerated rate of gluconeogenesis.
Xiao-Meng Sun, Xiao-Meng Sun, Xin Wu, Meng-Guang Wei, Meng-Guang Wei, Li-Zeng Zhu, Li-Zeng Zhu, Wen-hui Wu, Wen-hui Wu, Xin-Yue Zhou, Xin-Yue Zhou, Lian-Wen Qi, Qun Liu, Qun Liu   +13 more
doaj   +1 more source

Gluconeogenesis in the eel. IV. Gluconeogenesis in the hydrocortisone-administered eel.

NIPPON SUISAN GAKKAISHI, 1975
Gluconeogenesis of the hydrocortisone-administered eel was studied. Hydrocortisone administration produced a marked hyperglycemia. The liver of the treated eel showed an increase in weight with a concomitant increase in the amount of liver glycogen and in the activities of liver GOT, liver FDP, and liver PFK.
Yasuo Inui, Motoyoshi Yokote
openaire   +3 more sources

Compensation Response to Hepatic Gluconeogenesis via β‐Hydroxybutyrylation of FBP1 and PCK1 in Dairy Cows

Animal Research and One Health, EarlyView.
(1) Kbhb modification of FBP1 and PCK1 is involved in regulation of the gluconeogenesis pathway. (2) Kbhb of FBP1 and PCK1 is catalyzed by p300 and removed by HDACs. (3) BHB induced an increase in the enzymatic activity of FBP1 and PCK1 through Kbhb modification at the K43 site of FBP1 and the K191 site of PCK1.
DingPing Feng, GuoYan Wang, YuanYuan Zhu, YiNing Zheng, JunHu Yao, Lei Chen, Lu Deng   +6 more
wiley   +1 more source

Overview of Encapsulated Lysine and Methionine and Their Impacts on Transition Cow Performance and Health

Animal Research and One Health, EarlyView.
The transition period in dairy cows, spanning 3 weeks before and after calving, is a critical phase characterized by increased nutrient demands, reduced dry matter intake (DMI), and elevated risk of metabolic disorders such as negative nutrient balance (NNB), lipolysis, proteolysis, and oxidative stress.
Mohammed S. Seleem, Samy A. Elsaadawy, Zhaohai Wu, Lu Ma, Todd R. Callaway, Dengpan Bu   +5 more
wiley   +1 more source

Dietary supplement of sodium butyrate improves the growth performance and intestinal health by targeting Wnt/β‐catenin signaling pathway in rabbits

Animal Research and One Health, EarlyView.
Dietary supplement of sodium butyrate, may relate to regulating intestinal health and thus the growth performance and meat quality of rabbits by regulating the continuous process of promoting the periodic cycle of cecal epithelial cells. Abstract Supplementation of sodium butyrate (SB) has been proved to be beneficial for improving the growth ...
Mengke Ni, Zhitong Wang, Zhichao Li, Mengjuan Chen, Hui He, Hanfang Cai, Zhi Chen, Ming Li, Huifen Xu   +8 more
wiley   +1 more source