Results 161 to 170 of about 134,956 (333)

Selinexor Reduces the Immunosuppression of Macrophages and Synergizes With CD19 CAR‐T Cells Against B‐Cell Lymphoma

Cancer Science, EarlyView.
In the tumor microenvironment, selinexor suppresses tumor cell growth and prevents macrophages from polarizing to M2 populations. The lower concentration of selinexor decreases CAR‐T cell exhaustion, enhances its cytotoxicity, and upregulates NGFR expression to prompt CAR‐T cell proliferation.
Wenjing Luo, Jia Xu, Chenggong Li, Lu Tang, Yingying Li, Xindi Wang, Zhuolin Wu, Yinqiang Zhang, Heng Mei, Yu Hu   +9 more
wiley   +1 more source

The Fixation of Carbon Dioxide by Rat Liver Mitochondria and Its Relation to Gluconeogenesis

, 1965
Robert C. Haynes
openalex   +1 more source

RENAL GLUCONEOGENESIS. 2. THE GLUCONEOGENIC CAPACITY OF THE KIDNEY CORTEX OF VARIOUS SPECIES [PDF]

, 1963
HA KREBS, Takatoshi Yoshida
openalex   +1 more source

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source

Acid-Base Alterations and Renal Gluconeogenesis: Effect of pH, Bicarbonate Concentration, and PCO2*

, 1967
Donald E. Kamm, Robert E. Fuisz, Andrew Goodman, George F. Cahill   +3 more
openalex   +1 more source

Targeting Regulation of Macrophage to Treat Metabolic Disease: Role of Phytochemicals

Cell Proliferation, EarlyView.
One‐third of the world's population is affected by metabolic syndrome. Complicated pathogenesis and limited drugs cause the growing prevalence of metabolic syndrome. Macrophage‐mediated metaflammation is closely associated with the development of metabolic syndrome. The role of phytochemicals targeting macrophages in the treatment of metabolic syndrome
Zeting Ye, Yanlin Li, Xiaolin Yang, Chenglin Li, Rui Yu, Guangjuan Zheng, Zuqing Su   +6 more
wiley   +1 more source

Rapid and Effective Neuronal Conversion of Human Glioblastoma In Vitro and In Vivo Using Potent Small Molecules

Cell Proliferation, EarlyView.
A potent combination of small molecules YFSS (Y27632, Forskolin, SB431542, SP600125) that were screened through a neuronal‐specific promoter–reporter system TUBB3::mCherry effectively induces neuronal‐GBM conversion in vitro and in vivo, unveiling molecular mechanisms that offer a theoretical basis and a potential therapeutic strategy for treating GBM.
Ya'nan Hu, Jinming Liu, Jian Tu, Min Yang, Qisheng He, Fei Li, Xiaojing Xu, Zhongqing Ji, Jianwei Xu, Wentao Zhong, Mengwen Yan, Ying Yang, Huanxiang Zhang   +12 more
wiley   +1 more source

Regulation of gluconeogenesis during exposure of young rats to hypoxic conditions [PDF]

, 1971
F J Ballard
openalex   +1 more source

Lactate and Lactylation in AKI‐to‐CKD: Epigenetic Regulation and Therapeutic Opportunities

Cell Proliferation, EarlyView.
ABSTRACT Lactate is not only a byproduct of glycolysis, but is also considered an energy source, gluconeogenic precursor, signalling molecule and protein modifier during the process of cellular metabolism. The discovery of lactylation reveals the multifaceted functions of lactate in cellular metabolism and opens new avenues for lactate‐related research.
Yi Hou, Dongwei Liu, Zuishuang Guo, Cien Wei, Fengyu Cao, Yue Xu, Qi Feng, Fengxun Liu   +7 more
wiley   +1 more source

Paths of Carbon in Gluconeogenesis and Lipogenesis

, 1967
Myron A. Mehlman, Paul Walter, Henry A. Lardy   +2 more
openalex   +1 more source