Results 171 to 180 of about 88,788 (276)

NSUN4‐dependent m5C modification facilitates mitochondrial fission to accelerate diabetic nephropathy process via regulating SMURF1/CAMK1 axis

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
NSUN4‐mediated upregulation of SMURF1 promoted mitochondrial fission and inhibited mitochondrial fusion to accelerate DN progression via increasing CAMK1 ubiquitination. Abstract Background NOP2/Sun RNA methyltransferase family member 4 (NSUN4)‐mediated 5‐methylcytosine (m5C) modification has been implicated in diabetes‐related diseases.
Danyi Yang, Yinyin Chen, Hao Li, Guoyong Liu, Yang Gao, Liyu He   +5 more
wiley   +1 more source

Glucosamine/chitosan blend surface-engineered rutin-loaded polymer/lipid hybrid nanoparticles for neuroprotection in induced schizophrenia model. [PDF]

Sci Rep
Salama A, Elgohary R, Salama AH, Elmotasem H.   +3 more
europepmc   +1 more source

Comparing Chemoenzymatic and Conventional Synthetic Strategies to Wall Teichoic Acid Peptidoglycan Fragments

Israel Journal of Chemistry, Volume 66, Issue 5, September 2026.
The Gram‐positive bacteria, Staphylococcus aureus, contain wall teichoic acid (WTA, a glycopolymer (green and yellow)) is a virulence factor in their cell wall. Synthesis of the peptidoglycan‐(PG)‐WTA conjugate (blue squares) was developed via the phospho‐donor and PG acceptor (structures at the bottom right).
Min Liu, Kathleen C. Stathoulopoulos, Catherine Leimkuhler Grimes   +2 more
wiley   +1 more source

Glycoconjugate strategy for GLUT-driven curcumin delivery and anticancer activity in breast cancer cells. [PDF]

Sci Rep
Hassan SS, Rashidi FB, Seddik RG, El-Sayed AW, Mohamed HA, Mohamed HW, Kenawy MM, Hussein NB, Afify NA, Megahed NM, Zeinhom RM, Abdultawab ZA, Elgohary A, Hamido N, Elwakil AI, Alzoghaly HA, Nabil MO, Ahmed EA, Ismail KM.   +18 more
europepmc   +1 more source

Profiling the Glycosignature of Commercial Pepsin‐Soluble Type I Collagen Preparations: A MultiModal Lectin Strategy Reveals Latent Batch Variability

Journal of Biomedical Materials Research Part A, Volume 114, Issue 9, September 2026.
ABSTRACT Type I collagen (Col‐I) is widely used in biomaterials and cell biology, yet the glycosignature of commercial Col‐I preparations remains poorly characterized. Here, we established an integrated lectin‐based workflow to profile the glycan landscape of commercially sourced bovine pepsin‐soluble Col‐I as supplied for biomaterial use.
Mohamed EL‐Melegy, Amir M. Alsharabasy, Abhay Pandit   +2 more
wiley   +1 more source

A Comparison of Clinical Outcomes Among Undenatured Collagen Type II, Glucosamine Sulfate, and Diacerein on Osteoarthritic Knee Treatment: A Randomized Clinical Trial. [PDF]

JB JS Open Access
Narkbunnam R, Awirotananon K, Chareancholvanich K, Achawakulthep C, Adulkasem N, Chatmaitri S, Hirunyachoke P, Pornrattanamaneewong C.   +7 more
europepmc   +1 more source

Proteo‐Metabolomic Profiling of PMM2‐CDG Reveals Dysregulation of Retinoic Acid Synthesis, Myo‐Inositol, and the Hexosamine Pathway

Journal of Inherited Metabolic Disease, Volume 49, Issue 5, September 2026.
ABSTRACT Phosphomannomutase deficiency (PMM2‐CDG), the most common congenital disorder of glycosylation (CDG), is characterized by multisystem involvement and a lack of disease‐modifying therapies. While previous transcriptomic studies have uncovered disrupted cellular pathways, the functional consequences of these alterations remain poorly understood.
Diana Gallego, Giuseppina Andreotti, Maria Monticelli, Debora Paris, Arturo Martín‐Martínez, Alejandra Gámez, Mercedes Serrano, José Córdoba‐Caballero, Pedro Seoane, Juan A. G. Ranea, Belén Pérez   +10 more
wiley   +1 more source

Glucosamine induces apoptosis of cholangiocarcinoma cells by suppressing high-mannose type <i>N</i>-glycosylation and EGFR/STAT3 signaling. [PDF]

Future Sci OA
Waenphimai O, Taebprakhon C, Phoomak C, Chu C, Silsirivanit A, Wongkham S, Saengboonmee C.   +6 more
europepmc   +1 more source

Heparan Sulfate Proteoglycans: Master Regulators of Cellular Signaling, Tissue Development, and Neural Function

Journal of Neuroscience Research, Volume 104, Issue 9, September 2026.
Ubiquitous cell‐associated, cytoplasmic, synaptic and extracellular matrix HS‐proteoglycans are multifunctional regulators of tissue form and function. HS‐proteoglycans have diverse functions as growth factor co‐receptors in cell proliferation, differentiation, tissue development, mechanical stabilization, synaptogenesis, synaptic plasticity, and ...
James Melrose
wiley   +1 more source

Metabolic reprogramming in polyol pathway contributes to anti-inflammatory effect of glucosamine salts on synovial fibroblasts. [PDF]

NPJ Metab Health Dis
Okada J, Nakano R, Kitanaka N, Kitanaka T, Namba S, Nakano M, Naruke A, Nunomura J, Suwabe Y, Konno T, Tohi T, Kuno S, Kimura T, Uechi M, Nakayama T, Yamazaki J, Sugiya H.   +16 more
europepmc   +1 more source