Arthritogenic T cell epitope in glucose-6-phosphate isomerase-induced arthritis [PDF]
Arthritis Research & Therapy, 2008 IntroductionArthritis induced by immunisation with glucose-6-phosphate isomerase (GPI) in DBA/1 mice was proven to be T helper (Th) 17 dependent. We undertook this study to identify GPI-specific T cell epitopes in DBA/1 mice (H-2q) and investigate the ...
Keiichi Iwanami +7 more
semanticscholar +8 more sources
Glucose-6-phosphate isomerase is not a specific autoantigen in rheumatoid arthritis [PDF]
Rheumatology, 2003 OBJECTIVE To test the hypothesis that glucose-6-phosphate isomerase (GPI) is a novel autoantigen in RA. METHODS Eighty-eight serum samples from 23 patients with rheumatoid arthritis (RA), 25 with Sjögren's syndrome, 20 with systemic lupus erythematosus
Christine Hervé
semanticscholar +4 more sources
Molecular Biology and Evolution, 2007 Glucose-6-phosphate isomerase (GPI) has an essential function in both catabolic glycolysis and anabolic gluconeogenesis and is universally distributed among Eukaryotes, Bacteria, and some Archaea. In addition to the cytosolic GPI, land plant chloroplasts
Carina Grauvogel +2 more
semanticscholar +5 more sources
Glucose-6-phosphate isomerase is necessary for embryo implantation in the domestic ferret [PDF]
Proceedings of the National Academy of Sciences, 2003 The mechanism of implantation in carnivores is poorly understood. However, a previously unidentified 60-kDa protein has been shown to be necessary for embryo implantation in ferrets. Here we identify this protein as glucose-6-phosphate isomerase (GPI).
Laura C. Schulz, Janice M. Bahr
semanticscholar +5 more sources
A putative glucose 6-phosphate isomerase has pleiotropic functions on virulence and other mechanisms in Acidovorax citrulli [PDF]
Frontiers in Plant Science, 2023 Acidovorax citrulli (Ac) is a causal agent of watermelon bacterial fruit blotch (BFB) disease. Because resistance cultivars/lines have not yet been developed, it is imperative to elucidate Ac’s virulence factors and their mechanisms to develop resistant ...
Lynn Heo +5 more
doaj +2 more sources
Whole-transcriptome Analysis of Fully Viable Energy Efficient Glycolytic-null Cancer Cells Established by Double Genetic Knockout of Lactate Dehydrogenase A/B or Glucose-6-Phosphate Isomerase. [PDF]
Cancer Genomics Proteomics, 2020 Background/Aim: Nearly all mammalian tumors of diverse tissues are believed to be dependent on fermentative glycolysis, marked by elevated production of lactic acid and expression of glycolytic enzymes, most notably lactic acid dehydrogenase (LDH ...
Mazzio E +6 more
europepmc +2 more sources
Case report: Glucose 6-phosphate-isomerase deficiency combine with avascular necrosis of bilateral femoral head [PDF]
Frontiers in Pediatrics, 2022 BackgroundGlucose 6-phosphate-isomerase deficiency (GPI) is an uncommon autosomal recessive genetic disorder characterized by chronic asphoric hemolytic anemia, jaundice, and hepatospleenomegaly of varying degrees.
Zhenqi Song +6 more
doaj +2 more sources
B cell depletion reduces the number of autoreactive T helper cells and prevents glucose-6-phosphate isomerase-induced arthritis. [PDF]
PLoS ONE, 2011 The therapeutic benefit of B cell depletion in patients with rheumatoid arthritis has provided proof of concept that B cells are relevant for the pathogenesis of arthritis. It remains unknown which B cell effector functions contribute to the induction or
Oliver Frey +4 more
doaj +3 more sources
Disrupting glucose-6-phosphate isomerase fully suppresses the "Warburg effect" and activates OXPHOS with minimal impact on tumor growth except in hypoxia. [PDF]
Oncotarget, 2017 As Otto Warburg first observed, cancer cells largely favor fermentative glycolysis for growth even under aerobic conditions. This energy paradox also extends to rapidly growing normal cells indicating that glycolysis is optimal for fast growth and ...
de Padua MC +9 more
europepmc +2 more sources
Hereditary nonspherocytic hemolytic anemia caused by glucose-6-phosphate isomerase (GPI) deficiency in a Chinese patient: a case report [PDF]
BMC Pediatrics, 2022 Background Glucose phosphate isomerase (GPI) deficiency is a rare autosomal recessive disorder that causes hereditary nonspherocytic hemolytic anemia (HNSHA).
Yumei Zu +3 more
doaj +2 more sources