Glucose-6-Phosphate Isomerase (G6PI) Mediates Hypoxia-Induced Angiogenesis in Rheumatoid Arthritis. [PDF]
Sci Rep, 2017 The higher level of Glucose-6-phosphate isomerase (G6PI) has been found in both synovial tissue and synovial fluid of rheumatoid arthritis (RA) patients, while the function of G6PI in RA remains unclear.
Lu Y +7 more
europepmc +5 more sources
Association of autoantibodies to glucose‐6‐phosphate isomerase with extraarticular complications in rheumatoid arthritis [PDF]
Arthritis & Rheumatism, 2004 OBJECTIVE In the K/BxN mouse model, autoantibodies against glucose-6-phosphate isomerase (GPI) cause arthritis. The relevance of this model for human disease remains a subject of controversy.
Floris A. van Gaalen +6 more
semanticscholar +7 more sources
Arthritogenic T cell epitope in glucose-6-phosphate isomerase-induced arthritis [PDF]
Arthritis Research & Therapy, 2008 IntroductionArthritis induced by immunisation with glucose-6-phosphate isomerase (GPI) in DBA/1 mice was proven to be T helper (Th) 17 dependent. We undertook this study to identify GPI-specific T cell epitopes in DBA/1 mice (H-2q) and investigate the ...
Keiichi Iwanami +7 more
semanticscholar +6 more sources
Molecular Biology and Evolution, 2007 Glucose-6-phosphate isomerase (GPI) has an essential function in both catabolic glycolysis and anabolic gluconeogenesis and is universally distributed among Eukaryotes, Bacteria, and some Archaea. In addition to the cytosolic GPI, land plant chloroplasts
Carina Grauvogel +2 more
semanticscholar +5 more sources
Whole-transcriptome Analysis of Fully Viable Energy Efficient Glycolytic-null Cancer Cells Established by Double Genetic Knockout of Lactate Dehydrogenase A/B or Glucose-6-Phosphate Isomerase. [PDF]
Cancer Genomics Proteomics, 2020 Background/Aim: Nearly all mammalian tumors of diverse tissues are believed to be dependent on fermentative glycolysis, marked by elevated production of lactic acid and expression of glycolytic enzymes, most notably lactic acid dehydrogenase (LDH ...
Mazzio E +6 more
europepmc +2 more sources
B cell depletion reduces the number of autoreactive T helper cells and prevents glucose-6-phosphate isomerase-induced arthritis. [PDF]
PLoS ONE, 2011 The therapeutic benefit of B cell depletion in patients with rheumatoid arthritis has provided proof of concept that B cells are relevant for the pathogenesis of arthritis. It remains unknown which B cell effector functions contribute to the induction or
Oliver Frey +4 more
doaj +3 more sources
Disrupting glucose-6-phosphate isomerase fully suppresses the "Warburg effect" and activates OXPHOS with minimal impact on tumor growth except in hypoxia. [PDF]
Oncotarget, 2017 As Otto Warburg first observed, cancer cells largely favor fermentative glycolysis for growth even under aerobic conditions. This energy paradox also extends to rapidly growing normal cells indicating that glycolysis is optimal for fast growth and ...
de Padua MC +9 more
europepmc +2 more sources
Glucose-6-phosphate Isomerase as a Marker of a Fertility Restorer Gene in Rape - Short Communication [PDF]
Czech Journal of Genetics and Plant Breeding, 2003 In breeding of winter rape (Brassica napus L. var. napus) using the OGU-INRA system, based on cytoplasmic male sterility (CMS), it is necessary to distinguish pollen-sterile lines, carrying CMS factors and the recessive fertility restorer alleles rfrf ...
J. Horáček, M. Ačanová
doaj +2 more sources
Hereditary nonspherocytic hemolytic anemia caused by glucose-6-phosphate isomerase (GPI) deficiency in a Chinese patient: a case report [PDF]
BMC Pediatrics, 2022 Background Glucose phosphate isomerase (GPI) deficiency is a rare autosomal recessive disorder that causes hereditary nonspherocytic hemolytic anemia (HNSHA).
Yumei Zu +3 more
doaj +2 more sources
Oxidation Resistance 1 Modulates Glycolytic Pathways in the Cerebellum via an Interaction with Glucose-6-Phosphate Isomerase. [PDF]
Mol Neurobiol, 2019 Glucose metabolism is essential for the brain: it not only provides the required energy for cellular function and communication but also participates in balancing the levels of oxidative stress in neurons.
Finelli MJ +7 more
europepmc +2 more sources