Results 191 to 200 of about 19,271 (221)

Glucagon-like Peptide 1, Glucose-Dependent Insulinotropic Polypeptide, and Glucagon Receptor Agonists in Metabolic Dysfunction-Associated Steatotic Liver Disease: Novel Medication in New Liver Disease Nomenclature. [PDF]

Int J Mol Sci
Chrysavgis LG, Kazanas S, Bafa K, Rozani S, Koloutsou ME, Cholongitas E.   +5 more
europepmc   +1 more source

Caraterização da distribuição relativa de células neuroendócrinas no jejuno-íleo [PDF]

, 2013
Tiago André Pereira Guedes
core  

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Glucose-dependent insulinotropic polypeptide (GIP) and cardiovascular disease

Peptides, 2020
Accumulating evidence suggests that glucose-dependent insulinotropic polypeptide (GIP) in addition to its involvement in type 2 diabetic pathophysiology may be involved in the development of obesity and the pathogenesis of cardiovascular disease. In this review, we outline recent preclinical and clinical cardiovascular-related discoveries about GIP ...
Sebastian M. Heimbürger, Natasha C. Bergmann, Robert Augustin, Lærke S. Gasbjerg, Mikkel B. Christensen, Filip K. Knop   +5 more
openaire   +3 more sources

Glucose-dependent insulinotropic polypeptide/gastric inhibitory polypeptide

Best Practice & Research Clinical Endocrinology & Metabolism, 2004
The 42 amino acid polypeptide glucose-dependent insulinotropic polypeptide/gastric inhibitory polypeptide (GIP) is released from intestinal K-cells in response to nutrient ingestion. Based on animal studies, the peptide was initially assumed to act as an endogenous inhibitor of gastric acid secretion.
Juris J. Meier, Michael A. Nauck
openaire   +1 more source

Evolutionary expression of glucose-dependent-insulinotropic polypeptide (GIP)

Regulatory Peptides, 2011
Glucose-dependent insulinotropic polypeptide (GIP) is a mammalian incretin hormone released into the circulation following nutrient ingestion. We examined the functional evolution of GIP and its relationship with insulin to delineate their respective roles in promoting nutrient efficiency.
Michelle C, Musson, Lisa I, Jepeal, John R, Finnerty, M Michael, Wolfe   +3 more
openaire   +2 more sources

Structure-Activity Relationships of Glucose-Dependent Insulinotropic Polypeptide (GIP)

Biological Chemistry, 2003
Six GIP(1-NH2) analogs were synthesized with modifications (de-protonation, N-methylation, reversed chirality, and substitution) at positions 1, 3, and 4 of the N-terminus, and additionally, a cyclized GIP derivative was synthesized. The relationship between altered structure to biological activity was assessed by measuring receptor binding affinity ...
Simon A, Hinke, Rick, Gelling, Susanne, Manhart, Francis, Lynn, Raymond A, Pederson, Kerstin, Kühn-Wache, Fred, Rosche, Hans-Ulrich, Demuth, David, Coy, Christopher H S, McIntosh   +9 more
openaire   +2 more sources

Glucose‐dependent Insulinotropic Polypeptide (GIP) Stimulates Transepithelial Glucose Transport

Obesity, 2008
The purpose of this study was to characterize the effects of glucose‐dependent insulinotropic peptide (GIP) on small intestinal glucose transport in vitro. Stripped proximal jejunum from fasted mice was mounted in Ussing chambers. The serosal side was bathed in Regular Ringer solution containing 5 mmol/l glucose, and the mucosal side, with solution ...
Satish K, Singh, Aaron C, Bartoo, Selvi, Krishnan, Michael O, Boylan, John H, Schwartz, M, Michael Wolfe   +5 more
openaire   +2 more sources

Functional analysis of glucose-dependent insulinotropic polypeptide fusion proteins

Peptides, 2001
To generate functional fluorescently tagged glucose-dependent insulinotropic polypeptide (GIP), a series of GIP expression constructs were devised. These included G1 (complete preprohormone), G2 (lacking the C-terminal extension), G3 (lacking both N- and C-terminal extensions), G4 (G2 fused to green fluorescent protein, GFP), and G5 (G3 fused to GFP ...
K H, Ding, C M, Isales, Q, Zhong, R J, Bollag   +3 more
openaire   +2 more sources

Central Regulation of Glucose-Dependent Insulinotropic Polypeptide Secretion

2010
Glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1) are potent stimulators of glucose-dependent insulin secretion, a phenomenon known as incretin effect. After food ingestion, the circulating levels of GIP and GLP-1 rise more quickly than could be explained by the arrival of unabsorbed nutrients that have a direct ...
Maria P, Yavropoulou, John G, Yovos
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