mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue [PDF]
, 2016 Activation of non-shivering thermogenesis (NST) in brown adipose tissue (BAT) has been proposed as an anti-obesity treatment. Moreover, cold-induced glucose uptake could normalize blood glucose levels in insulin-resistant patients.
Albert V +12 more
core +4 more sources
Ambient but not local lactate underlies neuronal tolerance to prolonged glucose deprivation [PDF]
, 2018 Neurons require a nearly constant supply of ATP. Glucose is the predominant source of brain ATP, but the direct effects of prolonged glucose deprivation on neuronal viability and function remain unclear.
Mennerick, Steven +3 more
core +3 more sources
Effects of aging on glucose-mediated glucose disposal and glucose transport. [PDF]
Journal of Clinical Investigation, 1986 To assess the effects of aging on glucose-mediated glucose disposal and glucose transport, glucose disposal rates were measured in 10 nonelderly (32 +/- 4 yr) and 11 elderly (64 +/- 4 yr) subjects at five different plasma glucose concentrations. Glucose disposal was decreased by 30-35% in the elderly at each level of glycemia (100-350 mg/dl) in the ...
Penny Wallace +2 more
openaire +3 more sources
Glucose Metabolism and Glucose Transporters in Breast Cancer [PDF]
Frontiers in Cell and Developmental Biology, 2021 Breast cancer is the most common malignancy in women worldwide and is associated with high mortality rates despite the continuously advancing treatment strategies. Glucose is essential for cancer cell metabolism owing to the Warburg effect. During the process of glucose metabolism, various glycolytic metabolites, such as serine and glycine metabolites,
Ja Seung Koo, Eunah Shin
openaire +5 more sources
Glucose enhancement of memory is modulated by trait anxiety in healthy adolescent males [PDF]
, 2011 Glucose administration is associated with memory enhancement in healthy young individuals under conditions of divided attention at encoding. While the specific neurocognitive mechanisms underlying this ‘glucose memory facilitation effect’ are currently ...
Chiron C +14 more
core +1 more source
Bivariate genetic modelling of the response to an oral glucose tolerance challenge: A gene x environment interaction approach [PDF]
, 2009 AIMS/HYPOTHESIS: Twin and family studies have shown the importance of genetic factors influencing fasting and 2 h glucose and insulin levels. However, the genetics of the physiological response to a glucose load has not been thoroughly investigated ...
AJ Hanley +36 more
core +4 more sources
Dose-response between frequency of breaks in sedentary time and glucose control in type 2 diabetes: a proof of concept study [PDF]
, 2019 Objectives This study aimed to investigate dose-response between frequency of breaks in sedentary time and glucose control.DesignRandomised three-treatment, two-period balanced incomplete block trial.MethodsTwelve adults with type 2 diabetes (age, 60 ...
Chastin, Sebastien F.M. +5 more
core +2 more sources
GLUT2, glucose sensing and glucose homeostasis [PDF]
Diabetologia, 2014 The glucose transporter isoform GLUT2 is expressed in liver, intestine, kidney and pancreatic islet beta cells, as well as in the central nervous system, in neurons, astrocytes and tanycytes. Physiological studies of genetically modified mice have revealed a role for GLUT2 in several regulatory mechanisms.
openaire +4 more sources
Niosomes and polymeric chitosan based vesicles bearing transferrin and glucose ligands for drug targeting [PDF]
, 2000 PURPOSE: To prepare polymeric vesicles and niosomes bearing glucose or transferrin ligands for drug targeting. METHODS: A glucose-palmitoyl glycol chitosan (PGC) conjugate was synthesised and glucose-PGC polymeric vesicles prepared by sonication of ...
Couet, W. +7 more
core +1 more source