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Frontiers in Nutrition, 2022 Branched-chain amino acids (BCAAs), composed of leucine, isoleucine, and valine, are important essential amino acids in human physiology. Decades of studies have revealed their roles in protein synthesis, regulating neurotransmitter synthesis, and the ...
Chuang Du +16 more
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GLUT2, glucose sensing and glucose homeostasis [PDF]
Diabetologia, 2014 The glucose transporter isoform GLUT2 is expressed in liver, intestine, kidney and pancreatic islet beta cells, as well as in the central nervous system, in neurons, astrocytes and tanycytes. Physiological studies of genetically modified mice have revealed a role for GLUT2 in several regulatory mechanisms.
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BMC Medical Genomics, 2023 Background Colorectal cancer is a malignant tumor that poses a serious threat to human health. The main objective of this study is to investigate the mechanism by which Jatrorrhizine (JAT), a root extract from Stephania Epigaea Lo, exerts its anticancer ...
Lingyu Huang +8 more
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Circulation, 1999 The homeostasis of plasma glucose levels is essential for survival of the mammalian organism. Since blood glucose concentration is maintained within a narrow range, glucose is a most reliable substrate for energy production in the heart. The importance of glucose metabolism via glycolysis is well appreciated in ischemic and hypertrophied heart muscle,1
Heinrich Taegtmeyer +2 more
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Frontiers in Microbiology, 2022 BackgroundObesity has become a global health and socioeconomic problem because of an inadequate balance between energy intake and energy expenditure. Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) are the two most commonly used strategies ...
Jing Yang +19 more
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Machine learning for the diagnosis of early stage diabetes using temporal glucose profiles [PDF]
, 2020 Machine learning shows remarkable success for recognizing patterns in data. Here we apply the machine learning (ML) for the diagnosis of early stage diabetes, which is known as a challenging task in medicine. Blood glucose levels are tightly regulated by two counter-regulatory hormones, insulin and glucagon, and the failure of the glucose homeostasis ...
arxiv +1 more source
Role of leptin up-regulated GRP78 expression in migration of lung cancer cells
Di-san junyi daxue xuebao, 2020 Objective To investigate the effect of leptin on the migration of lung cancer cell lines A549 and H460 and the potential mechanisms. Methods The GEPIA website was used to analyze the correlation of the expression levels of leptin and glucose-regulated ...
WU Youqile +4 more
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Zhongguo gonggong weishengA growing body of research suggests a correlation between probiotic supplementation during pregnancy and the prevention and treatment of pregnancy complications.
Jing YANG +5 more
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