Modeling Physical Activity Impact on Glucose Dynamics in People with Type 1 Diabetes for a Fully Automated Artificial Pancreas [PDF]
arXiv, 2023 In this paper, models of the blood glucose (BG) dynamics in people with Type 1 diabetes (T1D) in response to moderate intensity aerobic activity are derived from physiology-based first principles and system identification experiments. We show that by enhancing insulin-dependent glucose utilization by the tissues in two phases, a rapid short-term ...
arxiv
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source
Sounding the metabolic orchestra: A delay dynamical systems perspective on the glucose-insulin regulatory response to on-off glucose infusion [PDF]
arXiv, 2023 We investigate the consequences of periodic, on-off glucose infusion on the glucose-insulin regulatory system on the basis of a system-level mathematical model with two explicit time delays. Studying the effects of such infusion protocols is mathematically challenging yet a promising direction for probing the system response to infusion. We pay special
arxiv
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Protein-centric omics analysis reveals circulating complements linked to non-viral liver diseases as potential therapeutic targets [PDF]
Clinical and Molecular HepatologyBackground/Aims To evaluate the causal correlation between complement components and non-viral liver diseases and their potential use as druggable targets.
Yingzhou Shi +14 more
doaj +1 more source
The glucose sensor in HIT cells is the glucose transporter [PDF]
FEBS Letters, 1987 The nature of the rate‐limiting step for glucose utilization by the clonal insulin‐producing cell line HIT‐T15 has been investigated. In contrast to the situation in islets of Langerhans, we find that the HIT cell glucose metabolism is limited by the rate of entry of glucose into the cell. This is evidenced by the low rate of sugar transport and by the
Mark Stubbs, S. J. H. Ashcroft
openaire +3 more sources
Identification of novel small molecule inhibitors of ETS transcription factors
FEBS Letters, EarlyView.ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla +9 more
wiley +1 more source
Autoimmune thyroid disease and ovarian hypofunction: a review of literature
Journal of Ovarian ResearchThyroid hormones(THs) are essential for the proper functioning of the ovaries, and multiple studies have shown that thyroid abnormalities, especially during adolescence and reproductive age, can lead to lifelong ovarian dysfunction.
Ru Wang +5 more
doaj +1 more source
Scalable, Non-Invasive Glucose Sensor Based on Boronic Acid Functionalized Carbon Nanotube Transistors [PDF]
, 2013 We developed a scalable, label-free all-electronic sensor for D-glucose based on a carbon nanotube transistor functionalized with pyrene-1-boronic acid. This sensor responds to glucose in the range 1 uM - 100 mM, which includes typical glucose concentrations in human blood and saliva.
arxiv +1 more source
Learning Absorption Rates in Glucose-Insulin Dynamics from Meal Covariates [PDF]
arXiv, 2023 Traditional models of glucose-insulin dynamics rely on heuristic parameterizations chosen to fit observations within a laboratory setting. However, these models cannot describe glucose dynamics in daily life. One source of failure is in their descriptions of glucose absorption rates after meal events.
arxiv