Results 61 to 70 of about 4,211,438 (402)

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

A systemic review on association between on maternal atmospheric pollution exposure during pregnancy and childhood obesity

环境与职业医学
BackgroundMaternal atmospheric pollution during pregnancy may alter fetal intrauterine development programming, thereby increasing the risk of childhood obesity in the future.ObjectiveTo investigate the effects of atmospheric pollution exposure during ...
Lu ZHENG, Borui LIU, Ningyu WAN, Xiaochuan WANG, Zhe YANG, Jiajin HU   +5 more
doaj   +1 more source

Brain Glucose Metabolism: Integration of Energetics with Function.

Physiological Reviews, 2019
Glucose is the long-established, obligatory fuel for brain that fulfills many critical functions, including ATP production, oxidative stress management, and synthesis of neurotransmitters, neuromodulators, and structural components.
G. Dienel
semanticscholar   +1 more source

Effect of Progressive Weight Loss on Lactate Metabolism: A Randomized Controlled Trial. [PDF]

, 2018
OBJECTIVE:Lactate is an intermediate of glucose metabolism that has been implicated in the pathogenesis of insulin resistance. This study evaluated the relationship between glucose kinetics and plasma lactate concentration ([LAC]) before and after ...
Chondronikola, Maria, Klein, Samuel, Magkos, Faidon, Muehlbauer, Michael J, Newgard, Christopher B, Okunade, Adewole L, Patterson, Bruce W, Yoshino, Jun   +7 more
core   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Metabolic and hormonal studies of Type 1 (insulin-dependent) diabetic patients after successful pancreas and kidney transplantation [PDF]

, 1991
Long-term normalization of glucose metabolism is necessary to prevent or ameliorate diabetic complications. Although pancreatic grafting is able to restore normal blood glucose and glycated haemoglobin, the degree of normalization of the deranged ...
AD Baron, B Glaser, D. Abendroth, DER Sutherland, E Bosi, F. Fiedler, G Tyd�n, GB Bolli, GC Weir, GK Stalla, J Nusser, J �stman, J. Nusser, JD Peuler, K Osei, K Werder v, KF Hanssen, L Luzi, LG Heding, P Diem, P Diem, PG Passon, R Landgraf, R. L. Riepl, R. Landgraf, RJ Jarrett, RL Riepl, RP Eaton, SA Amiel, TW Schwartz, W Land, W Land, W. -D. Illner, W. Land   +33 more
core   +2 more sources

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

The Melanocortin-4 Receptor Integrates Circadian Light Cues and Metabolism [PDF]

, 2015
The melanocortin system directs diverse physiological functions from coat color to body weight homoeostasis. A commonality among melanocortin-mediated processes is that many animals modulate similar processes on a circannual basis in response to longer ...
Arble, Deanna M., Herman, James P., Holland, Jenna, Morano, Rachel, Ottaway, Nickki, Perez-Tilve, Diego, Pressler, Joshua W., Sandoval, Darleen A., Seeley, Randy J., Sorrell, Joyce, Woods, Stephen C.   +10 more
core   +2 more sources

Changes in neuronal activity across the mouse ventromedial nucleus of the hypothalamus in response to low glucose: evaluation using an extracellular multi‐electrode array approach [PDF]

, 2020
The hypothalamic ventromedial nucleus (VMN) is involved in maintaining systemic glucose homeostasis. Neurophysiological studies in rodent brain slices have identified populations of VMN glucose‐sensing neurones: glucose‐excited (GE) neurones, cells which
Beall, Craig, Ellacott, Kate L. J., Hanna, Lydia, Kawalek, Tristan J.   +3 more
core   +2 more sources

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source