Results 91 to 100 of about 446,689 (286)

Purification and properties of an unusual UDP-glucose dehydrogenase, NADPH-dependent, from Xanthomonas albilineans

, 2008
Xanthomonas albilineans produces a UDP-glucose dehydrogenase growing on sucrose. The enzyme oxidizes UDP-glucose to UDP-glucuronic acid by using molecular oxygen and NADPH.
Legaz González, María Estrella, Vicente Córdoba, Carlos, Blanch Rojo, María   +2 more
core   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Glucose-6-phosphate dehydrogenase contributes to the regulation of glucose uptake in skeletal muscle

, 2016
Objective: The development of skeletal muscle insulin resistance is an early physiological defect, yet the intracellular mechanisms accounting for this metabolic defect remained unresolved.
Hoffman, NJ (15694352), Iliades, P (15694364), Bruce, CR (15693713), McConell, GK (15515774), Gregorevic, P (15694163), Lynch, GS (15611264), Murphy, KT (15694355), Zivanovic, B (15694367), Colgan, TD (15694370), Kraakman, MJ (15694127), Febbraio, MA (15498638), Lee-Young, RS (15560264), Kingwell, BA (15526766), Hong, YH (15611255), Darren Henstridge (14738965), Greenfield, JR (15694373), Samocha-Bonet, D (15694358), Siebel, AL (15694361), Drummond, GR (15620900)   +18 more
core   +1 more source

Cloning, expression and characterization of P2-glucose-6P dehydrogenase from barley (Hordeum vulgare) and poplar (Populus trichocarpa. Effects of Abscissic acid (ABA) on activity, occurrence and expression of different isoforms of glucose-6P dehydrogenase in barley

, 2010
Glucose 6-phosphate dehydrogenase (G6PDH, EC 1.1.1.49) is the main regulatory enzyme of the oxidative pentose phosphate pathway (OPPP), an important provider of NADPH.
Cardi, Manuela
core  

Host erythrocyte polymorphisms and exposure to Plasmodium falciparum in Papua New Guinea. [PDF]

, 2008
Contains fulltext : 69991.pdf (Publisher’s version ) (Open Access)BACKGROUND: The protection afforded by human erythrocyte polymorphisms against the malaria parasite, Plasmodium falciparum, has been proposed to be due to reduced ability
Pilling, L, Michon, P., Ripley, R.M., Luty, A.J.F., Fowkes, FJ, Luty, AJ, Mgone, CS, Fowkes Freya JI, Ripley, Ruth, Woods, C.M., Imrie Heather J, Ripley Ruth M, Imrie, H.J., Tavul Livingstone, Luty, AJF, Pilling Lynn, Fowkes, FJI, Michon, P, Fowkes, F.J., Day, K.P., Woods, CM, Woods Caira M, Tavul, L., Tavul, L, Ripley, RM, Pilling, L., Mgone Charles S, Day Karen P, Luty Adrian JF, Mgone, C.S., Imrie, HJ, Michon Pascal, Day, KP   +32 more
core   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

The NRF2-CARM1 axis links glucose sensing to transcriptional and epigenetic regulation of the pentose phosphate pathway in gastric cancer

Cell Death and Disease
Cancer cells autonomously alter metabolic pathways in response to dynamic nutrient conditions in the microenvironment to maintain cell survival and proliferation.
Miaomiao Ping, Guangyao Li, Qijiao Li, Yang Fang, Taotao Fan, Jing Wu, Ruiyi Zhang, Lesha Zhang, Bing Shen, Jizheng Guo   +9 more
doaj   +1 more source

Electrospun membranes for implantable glucose biosensors [PDF]

, 2012
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel UniversityThe goal for this thesis was to apply electrospun biomimetic coatings on implantable glucose biosensors and test their efficacy as mass-transport limiting ...
Wang, Ning
core  

The level of mendione redox-cycling in pancreatic β-cells is proportional to the glucose concentration: role of NADH and consequences for insulin secretion

, 2012
Pancreatic β-cells release insulin in response to elevation of glucose from basal (4–7 mM) to stimulatory (8–16 mM) levels. Metabolism of glucose by the β-cell results in the production of low levels of reactive oxygen intermediates (ROI), such as ...
Womack, Trayce, Gray, Joshua P., Joshua P. Gray, Peter J.S. Smith, Smith, Peter J. S., Meridith Palo, Heart, Emma, Trayce Womack, Emma Heart   +8 more
core   +1 more source

The role of 11β-hydroxysteroid dehydrogenase type 1 in bile acid homeostasis [PDF]

, 2013
Bile acids (BAs) are important modulators of metabolic functions such as lipid, triglyceride and glucose homeostasis. Intrahepatic accumulation of BAs is known to cause liver injury in cholestatic conditions, where normal trans-hepatic BA flow is ...
Penno, Carlos Alberto
core   +1 more source