Results 41 to 50 of about 446,689 (286)

Hsp90β knockdown in DIO mice reverses insulin resistance and improves glucose tolerance

Nutrition & Metabolism, 2018
Background Inhibition of Hsp90 has been shown to improve glucose tolerance and insulin sensitivity in mouse models of diabetes. In the present report, the specific isoform Hsp90ab1, was identified as playing a major role in regulating insulin signaling ...
Enxuan Jing, Pragalath Sundararajan, Ishita Deb Majumdar, Suwagmani Hazarika, Samantha Fowler, Angela Szeto, Stephane Gesta, Armando J. Mendez, Vivek K. Vishnudas, Rangaprasad Sarangarajan, Niven R. Narain   +10 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Effect of an aqueous extract of Scoparia dulcis on blood glucose, plasma insulin and some polyol pathway enzymes in experimental rat diabetes

Brazilian Journal of Medical and Biological Research, 2004
The effects of an aqueous extract of the plant Scoparia dulcis (200 mg/kg) on the polyol pathway and lipid peroxidation were examined in the liver of streptozotocin adult diabetic male albino Wistar rats.
M. Latha, L. Pari
doaj   +1 more source

Reduction of m-chlorophenacyl chloride coupled with regeneration of NADPH by recombinant Escherichia coli cells co-expressing both carbonyl reductase and glucose 1-dehydrogenase

Annals of Microbiology, 2015
Both Sys1 and Sygdh, two codon-optimized genes encoding SyS1 and SyGDH, were synthesized based on the carbonyl reductase (S1) and glucose 1-dehydrogenase (GDH) gene sequences, respectively, from Candida magnoliae and Thermoplasma acidophilum, and co-expressed in Escherichia coli BL21(DE3) using two strategies.
Tao Yu, Jian-Fang Li, Li-Juan Zhu, Die Hu, Chao Deng, Yu-Ting Cai, Min-Chen Wu   +6 more
openaire   +1 more source

Metabolic responses of primary and transformed cells to intracellular Listeria monocytogenes. [PDF]

, 2012
The metabolic response of host cells, in particular of primary mammalian cells, to bacterial infections is poorly understood. Here, we compare the carbon metabolism of primary mouse macrophages and of established J774A.1 cells upon Listeria monocytogenes
Wolfgang Eisenreich (108576), Anette Schulz (108573), Andreas Götz (108569), Gillmaier, Nadine, Götz, Andreas, Nadine Gillmaier, Schulz, Anette, Werner Goebel, Goebel, Werner, Eisenreich, Wolfgang, Werner Goebel (7241), Andreas Götz, Anette Schulz, Wolfgang Eisenreich, Nadine Gillmaier (108566)   +14 more
core   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

High risk of severe anaemia after chlorproguanil-dapsone+artesunate antimalarial treatment in patients with G6PD (A-) deficiency. [PDF]

, 2008
BACKGROUND: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common inherited human enzyme defect. This deficiency provides some protection from clinical malaria, but it can also cause haemolysis after administration of drugs with oxidant ...
Modiano David, Fanello, C. I., Modiano, D., Karema, C., Lee, Sue, Bancone Germana, Uwimana, A, KAREMA C, Avellino Pamela, David Modiano, UWIMANA A, Uwimana, A., Fanello, CI, Germana Bancone, d'Alessandro Umberto, LEE SJ, Umberto d'Alessandro, Uwimana, Aline, Karema, C, Lee Sue J., Avellino, P, Modiano, D, Karema Corine, Pamela Avellino, Karema, Corine, D'Alessandro, U., D'ALESSANDRO U, Bancone, Germana, d'Alessandro, Umberto, Fanello Caterina I., Modiano, David, FANELLO CI, Fanello, Caterina I, Lee, S. J., Lee, Sue J, Sue J Lee, Corine Karema, Uwimana Aline, Aline Uwimana, D'Alessandro, U, Avellino, Pamela, Avellino, P., Caterina I Fanello, Bancone, G.   +43 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Isoenzyme genotyping and phylogenetic analysis of oxacillin-resistance Staphylococcus aureus isolates

Brazilian Journal of Oral Sciences, 2017
Aim: The propagation of S. aureus in hospital and dental environments is considered an important public health problem since resistant strains can cause serious infections in humans. The genetic variability of 99 oxacillin-resistant S.
Marcelo Fabiano Gomes Boriollo, Manoel Francisco Rodrigues Netto, Jeferson Júnior da Silva, Thaísla Andrielle da Silva, Maysa Eduarda de Castro, Júlio César Elias, José Francisco Höfling   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source