Results 241 to 250 of about 1,294,412 (315)

Measurement of brain glucose metabolism in obesity and diabetes. [PDF]

Diabetologia
Hwang JJ, Bini J, Belfort-DeAguiar R.
europepmc   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Association between sleep disorders and alterations in glucose metabolism, insulin, and glucagon in patients with type 2 diabetes. [PDF]

Medicine (Baltimore)
Song Z, Zhao H, Yu X, Sun X.
europepmc   +1 more source

Tim1 Deficiency Mediates Gestational Hyperglycemia‐Related Syncytiotrophoblast Dysfunction and Fetal Growth Restriction

Advanced Science, EarlyView.
Hyperglycemia during pregnancy impairs the fusion of trophoblast cells into syncytiotrophoblasts, leading to fetal growth restriction. This impaired fusion is mediated by Tim1 downregulation via hyperglycemia‐induced ROS. Antioxidant therapy during pregnancy promotes syncytiotrophoblast formation by upregulating Tim1 expression, thus alleviating fetal ...
Junsen She, Rui Liu, Chen Fang, Shuyu Zhang, Yizhi Hu, Fei Guo, Yuhang Long, Mengzhen Ding, Haiyan Wu, Bokang Zhou, Zexin Yang, Ying Jiang, Jianzhong Sheng, Ling Gao, Hefeng Huang   +14 more
wiley   +1 more source

Microglia Mitochondria Support Neuronal Maturation via Metabolic and Transcriptional Reprogramming in Human 3D In Vitro Brain Model

Advanced Science, EarlyView.
xx xx. ABSTRACT Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by disrupted neuronal circuit maturation. Emerging evidence implicates microglial function and mitochondrial regulation as contributors to ASD‐associated biology, yet the mechanisms linking these processes to neuronal development remain poorly defined ...
Sydney P. Sterben, Charitha C. Anamala, Sahan B. S. Kansakar, Vaishnavi Koduri, Volha Liaudanskaya   +4 more
wiley   +1 more source

Anoctamin 5 mutation leads to abnormal bone homeostasis of GDD by regulating AMPK-dependent glucose metabolism. [PDF]

Front Endocrinol (Lausanne)
Li H, Xu H, Sun K, Wang S, Zhang M, Lin L, Zhang S, Dong R, Hu Y.   +8 more
europepmc   +1 more source

Semaglutide Protects Retinal Ganglion Cells Against Rotenone-Induced Degeneration via Improved Glucose Metabolism. [PDF]

Invest Ophthalmol Vis Sci
Mouhammad ZA, Tribble JR, Nicol A, Andreopoulou E, García-Bermúdez MY, Aldana BI, Vohra R, Kolko M, Williams PA.   +8 more
europepmc   +1 more source

Tau pathology reprograms glucose metabolism to support cortical hyperexcitability, excitatory/inhibitory imbalance, and sleep loss. [PDF]

NPJ Dement
Irmen RE, Turner SM, Snipes JA, Schloss KH, Wang X, Williams HC, Velmurugan GV, Hunt JB, Li J, Sullivan PG, Lee DC, Bauer AQ, Johnson LA, Macauley SL.   +13 more
europepmc   +1 more source

Adipocytic sclerostin loop3-LRP4 interaction required by sclerostin to impair whole-body lipid and glucose metabolism. [PDF]

Nat Commun
Jiang H, Tao X, Yu S, Zhang Y, Ma Y, Li N, Wang S, Zhang N, Yang X, Ding S, Zhong C, Li H, Li Z, Wen X, Zhang H, Chen Z, Sun M, Luo H, Ren M, Lei C, Yu Y, Liu J, Zhang Z, Lyu A, Sheng H, Li D, Wang L, Zhang G, Zhang BT.   +28 more
europepmc   +1 more source

Association Between Iron Overload and Glucose Metabolism in Children and Youth with Transfusion-Dependent Beta Thalassemia: The Role of Chelation Therapy. [PDF]

Mediterr J Hematol Infect Dis
İncefidan İ, Kazancı EG, Güven D, Kara Ö.   +3 more
europepmc   +1 more source