Results 61 to 70 of about 1,294,412 (315)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Association between thyroid function and thyroid homeostasis parameters and the prevalence and all-cause and cardiovascular mortality of chronic kidney disease: a population-based study

BMC Public Health
Background To evaluate the relationship between thyroid function and thyroid homeostasis parameters with the prevalence of chronic kidney disease (CKD) and furtherly explore the all-cause and cardiovascular mortality among individuals with CKD using data
Xue Liu, Yuhao Zhang, Yuchen Li, Xiude Fan, Haiqing Zhang   +4 more
doaj   +1 more source

A stoichiometric reaction scheme for Saccharothrix algeriensis growth and thiolutin production [PDF]

, 2010
A new bacterial species, Saccharothrix algeriensis NRRL B-24137, was isolated in 1992 in the Sahara desert. This filamentous bacterium is able to produce dithiolopyrrolones, molecules presenting antibacterial, antifungal, and anticancer properties.
Brandam, Cédric, Lebrihi, Ahmed, Meyer, Xuân-Mi, Strub, Caroline   +3 more
core   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Heart rate response and recovery during exercise and dementia risk: a prospective UK biobank study

Scientific Reports
The heart rate response/recovery (HRR) index, a common indicator for cardiovascular health during exercise, has been linked with neurocognitive disorders and mortality.
Yiran Wei, Yonglin Shan, Wenxiao Fan, Xin Huang, Jiahao Ding, Ming Mao, Qianying Liu, Minle Tian, Xuewei Li, Jie Lu, Hongli Chang, Yi Dong, Yifeng Du, Chengxuan Qiu, Xiaolei Han, Yongxiang Wang   +15 more
doaj   +1 more source

The classification of obesity based on metabolic status redefines the readmission of non-Hodgkin’s lymphoma—an observational study

Cancer & Metabolism, 2023
Background The relationship between obesity and non-Hodgkin’s lymphoma (NHL) was controversial, which may be due to the crudeness definition of obesity based on body mass index (BMI).
Hang Dong, Honglin Guo, Jing Du, Yiping Cheng, Dawei Wang, Junming Han, Zinuo Yuan, Zhenyu Yao, Ran An, Xiaoqin Wu, Kyle L. Poulsen, Zhixiang Wang, Shanshan Shao, Xiude Fan, Zhen Wang, Jiajun Zhao   +15 more
doaj   +1 more source

Glucose Metabolism in Sheep Fed Grass Supplemented with Gliricidia Sepium [PDF]

, 2014
The limiting factor on improving ruminant production for most of the available feed in developing countries are low in quality. Therefore high fibre diet must be supplemented by high nutritivefeed such as leguminous trees that much available in those ...
Suharyono, S. (Suharyono), Teleni, E. (E), Widiawati, Y. (Y)   +2 more
core  

Impaired Glucose Metabolism in Liver Cirrhosis [PDF]

, 2013
Background: Approximately 30% of patients who suffer cirrhosis maybe diabetic, called hepatogenous diabetes (HD). Insulin resistance seems to be the pathophysiologic basis for HD.
Ndraha, S. (Suzanna), Santoso, M. (Mardi), Sunardi, I. D. (Ivan), Tendean, M. (Marshel), Wician, F. (Fendra)   +4 more
core   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Association of Sleep Duration With Incident Carotid Plaque: A Prospective Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Sleep is an important determinant of cardiovascular health. We sought to investigate the longitudinal association between sleep duration and incident carotid plaque in a rural Chinese population.
Meijie Chen, Xiaotong Ma, Yuan Xue, Xiang Wang, Yuanyuan Zhao, Peng Yan, Xiaohui Liu, Yifeng Du, Chengxuan Qiu, Qinjian Sun   +9 more
doaj   +1 more source