Results 211 to 220 of about 84,281 (289)

A multi-tetracycline responsive induction system for gene expression in <i>Bacillus subtilis</i>. [PDF]

Appl Environ Microbiol
Reich-Veillette K, Rhoads AE, Libby EA.
europepmc   +1 more source

Sugar Metabolisms Altered By Undissociated Forms of Organic Acids Based on the Emergence of [GAR+] Cells in Saccharomyces cerevisiae

Yeast, EarlyView.
ABSTRACT The glucose repression system is a mechanism for effective energy acquisition by glucose assimilation in microorganisms. In yeast, Saccharomyces cerevisiae, which is known as a prion‐like protein [GAR+], is involved in the bypass of glucose repression. It has been reported that the emergence of [GAR+] cells was promoted by lactate and acetate.
Koichi Tanabe, Atsuhiko Nakata, Mizuki Hosotani, Jun Shima   +3 more
wiley   +1 more source

<i>Candida albicans</i> promotes TSST-1 production by <i>Staphylococcus aureus</i> through glucose depletion and relief of CcpA-mediated repression. [PDF]

J Bacteriol
Carriou M, Badiou C, Soulard A, d'Enfert C, Dufresne K, Lina G.   +5 more
europepmc   +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

The selective degradation of PDE4B shortform, using a PROTAC, leads to inhibition of several hallmarks of cancer in HCT116 cells

British Journal of Pharmacology, EarlyView.
Background and Purpose Colorectal cancer is one of the most prevalent cancers worldwide, and novel precision medicine approaches are rapidly improving patient outcomes. Phosphodiesterase 4B (PDE4B) is a member of an enzyme family (PDE4) that hydrolyses intracellular cAMP to control spatial and temporal signalling cues.
Alina Zorn, John Daniel Pediani, Madihah Hussain, Jiayue Ling, Elaine Brown, Igor Belka, Eduardo Torres, Cathy Swindlehurst, Kyle Chan, David Stirling, George S. Baillie, Yuan Yan Sin   +11 more
wiley   +1 more source

Artificial repression looping control by regulated autoinhibition of transcription activator-like effector dimer proteins. [PDF]

Nucleic Acids Res
Becker NA, Peters JP, Maher Iii LJ.
europepmc   +1 more source

MAPK Inhibitor‐Tolerant Persister Cells in Melanoma: Mechanisms and Therapeutic Vulnerabilities

Cancer Science, EarlyView.
Melanoma response to MAPK inhibition progresses from drug‐sensitive cells to drug‐tolerant persister states, which enable survival through adaptive signaling, metabolic rewiring, and phenotypic plasticity. These persister cells serve as an intermediate reservoir from which resistant tumors ultimately emerge. ABSTRACT Though major advancements have been
Bhoomi Shah, Mackenzie M. Mayhew, Jacob Sellers, Russell G. Witt   +3 more
wiley   +1 more source

Systematic engineering of Escherichia coli for biosynthesis of 3-hydroxypropionic acid from glucose and malonate. [PDF]

BMC Biotechnol
Wang Y, Cao M, Hu M, Xu H, Du Y, Sun C, Kong L, Luo Y, Liu X, Yang J, Liang B.   +10 more
europepmc   +1 more source

Gasdermin‐Mediated Pyroptosis: Novel Strategies Against Colorectal Cancer

Cancer Science, EarlyView.
Pyroptosis is a double‐edged sword in colorectal cancer (CRC): chronic low‐grade pyroptosis promotes tumor progression, whereas acute induction of pyroptosis in cancer cells triggers antitumor immunity and enhances therapeutic response. Targeting gasdermin‐mediated pyroptosis represents a promising strategy for CRC treatment.
Kaibo Guo, Yuqian Feng, Jiamin Lu, Nuerbiye Abudurexiti, Xinlei Zhou, Mengfan Wei, Song Zheng   +6 more
wiley   +1 more source

H19 inhibition orchestrates DNMT3B-dependent epigenetic reprogramming of glycolytic enzymes in the liver during diabetes. [PDF]

Cell Commun Signal
Rizvi A, Kansal R, Datta M.
europepmc   +1 more source