Development of a high-throughput label-free method for enrichment of antimetabolite-resistant yeast strains using pico-litre agarose beads. [PDF]
Appl Microbiol BiotechnolGovindaraju SB +3 more
europepmc +1 more source
Proteostasis of organelles in aging and disease
The FEBS Journal, EarlyView.Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi +5 more
wiley +1 more source
Role of Sirtuin 6 in the Pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease. [PDF]
Curr Issues Mol BiolKim Y, Hwang S.
europepmc +1 more source
Quantitative analysis of DNA‐GATA1 binding alterations linked to hematopoietic disorders
The FEBS Journal, EarlyView.Native holdup allows the quantitative determination of affinities between full‐length transcription factors and DNA. Mutations in either the protein or the DNA can modulate binding strength, which can be precisely quantified using this approach. Applied to GATA1, it revealed mutations that alter DNA binding.
Boglarka Zambo +6 more
wiley +1 more source
Carbon metabolism and niche adaptation in <i>Streptococcus pyogenes</i> pathogenesis. [PDF]
mSphereXu W, Okumura CYM.
europepmc +1 more source
The R203W substitution drives PACS‐1 syndrome by disrupting intramolecular regulation
The FEBS Journal, EarlyView.The middle region (MR) of PACS‐1 controls engagement with specific partner proteins. This manuscript presents the structure of the Furin binding region (FBR) and how interactions with partners are regulated through the interplay between a basic patch in the FBR and an acidic cluster in the MR.
Troy C. Krzysiak +7 more
wiley +1 more source
A daily cycle of White Collar Complex dephosphorylation sustains circadian rhythmicity in <i>Neurospora</i>. [PDF]
Proc Natl Acad Sci U S AWang B, Zhou X, Loros JJ, Dunlap JC.
europepmc +1 more source
Characterization of carbon metabolism and glucose repression in yeasts
, 2013 openaire +2 more sources
KU80 suppresses endonuclease G activity to preserve genomic integrity
The FEBS Journal, EarlyView.Under normal conditions, EndoG remains restricted to mitochondria and the genome remains intact. When KU80 is absent, EndoG translocates into the nucleus, where it promotes DNA fragmentation and genomic instability. Thus, this work highlights the importance of KU80 in tightly controlling EndoG localization to preserve genome stability.
Jargalan Batsaikhan +8 more
wiley +1 more source