Results 221 to 230 of about 84,281 (289)

CKAP4 Regulates ERS‐Induced Apoptosis in Osteoclasts Through FOXO3 in Periodontitis

Cell Proliferation, EarlyView.
CKAP4 promotes the transcription of PERK via FOXO3 in OCs, thereby facilitating ER stress‐induced apoptosis. In periodontitis, the reduction of CKAP4 in OCs leads to decreased OC apoptosis, which exacerbates alveolar bone resorption. ABSTRACT Periodontitis is a prevalent oral disease characterised by chronic inflammation and irreversible alveolar bone ...
Jiayu Cheng, Dihao Tao, Wenzhe Wang, Huiyu Wang, Hanzhe Wang, Yufan Liang, Jia Guo, Wenhao Liu, Yiming Wang, Jianhua Yang, Xiaoning He, Ce Shan, Bei Li   +12 more
wiley   +1 more source

Fine modulation of carbon flow in central carbon metabolism via ribosome-binding site modification in <i>Escherichia coli</i>. [PDF]

Metab Eng Commun
Sawada S, Imada T, Nagai H, Mundt P, Matsuda F, Shimizu H, Toya Y.   +6 more
europepmc   +1 more source

Targeting Egfr‐Mediated Cell Proliferation and Lipid Metabolism Separation Effectively Accelerate Liver Regeneration

Cell Proliferation, EarlyView.
AREG coordinates cell proliferation and lipid metabolism reprogramming during liver regeneration and targeting lipid metabolism can promote liver regeneration. ABSTRACT Hepatocyte proliferation restores liver mass after partial hepatectomy (PHx), but the metabolic cost of this process remains unclear.
Yuelei Hu, Shifei Song, Ruilin Wang, Ni An, Jinmei Diao, Yuguo Chen, Juan Liu, Guoyue Lv   +7 more
wiley   +1 more source

Protective effect of pentoxifylline against high-glucose-induced ferroptosis in vascular smooth muscle cells. [PDF]

J Mol Endocrinol
Zhou J, Jiao L, Jin S, Ran Y, Meng X, Bai L, Xi Y, Wang J, Zhao Z.   +8 more
europepmc   +1 more source

Inflammatory Cytokines Impair Glucagon Expression and Secretion in Pancreatic α‐Cells

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Insulin resistance and obesity‐associated inflammation are key drivers in the pathogenesis of Type 2 diabetes mellitus (T2DM). Whilst inflammatory cytokines are well known to impair β‐cell function, their impact on pancreatic α‐cells and glucagon (GCG) regulation remains poorly understood. In this study, we investigated the effects of the
Caroline Bickelmann, Cedric Wilden, Leticia Prates‐Roma, Matthias W. Laschke, Emmanuel Ampofo, Selina Wrublewsky   +5 more
wiley   +1 more source

Integrated multi-dimensional modeling of non-model bacteria identifies engineering targets for acarbose biosynthesis optimization. [PDF]

Cell Rep Methods
Cai F, Zhang S, Dai Y, Zhao Z, Fu X, Kang Q, Shi Y, Wang Z, Bai L.   +8 more
europepmc   +1 more source

Mechanisms of Thrombocytosis in Iron‐Deficiency Anemia

European Journal of Haematology, EarlyView.
ABSTRACT Iron‐deficiency anemia is frequently accompanied by reactive thrombocytosis, yet the mechanisms underlying this association remain incompletely understood. Beyond impaired erythropoiesis, iron availability has emerged as an active regulator of hematopoietic lineage decisions.
João Vitor Facco, Diane S. Krause, Sara T. Olalla Saad   +2 more
wiley   +1 more source

The MdERF17-MdbHLH149 Module Mediates Ethylene-Induced Starch Degradation Through the Transcriptional Repression of α-Amylase MdAMY1 in Apple. [PDF]

Plant Biotechnol J
Xiao F, Wang CK, Zhang JC, Jian XY, Xiang Y, Zhang WJ, Meng JC, Wang WY, Hu DG.   +8 more
europepmc   +1 more source

Methods to Study Mitochondrial Metabolism and Homeostasis in Fission Yeast

Yeast, EarlyView.
Ferran Gómez‐Armengol, Elena Hidalgo, Montserrat Vega   +2 more
wiley   +1 more source

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

The FEBS Journal, EarlyView.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna, Alessandro Cherubini, Ersilia Varone, Serena Germani, Alice Marrazza, Ester Zito   +5 more
wiley   +1 more source