Results 151 to 160 of about 181,335 (186)

Exercise reduces muscle glucose transport protein (GLUT-4) mRNA in type 1 diabetic patients

Journal of Applied Physiology, 1993
We examined the effect of acute exercise on muscle glucose transporter (GLUT-4) protein and mRNA concentrations in nine male type 1 diabetic patients (age 31 +/- 3 yr, body mass index 23.6 +/- 0.7 kg/m2, insulin dose 44 +/- 4 U/day, glycosylated hemoglobin 7.8 +/- 0.4%) and in nine healthy control subjects (34 +/- 1 yr, 25.3 +/- 0.8 kg/m2).
V A, Koivisto, R E, Bourey, H, Vuorinen-Markkola, L, Koranyi   +3 more
openaire   +2 more sources

Daidzein promotes glucose uptake through glucose transporter 4 translocation to plasma membrane in L6 myocytes and improves glucose homeostasis in Type 2 diabetic model mice

The Journal of Nutritional Biochemistry, 2014
Daidzein shows estrogenic, antioxidant and antiandrogenic properties as well as cell cycle regulatory activity. However, the antihyperglycemic effect of daidzein remains to be elucidated. In this study, we investigated the in vitro effect of daidzein on glucose uptake, AMPK phosphorylation and GLUT4 translocation on plasma membrane in L6 myotubes and ...
Sun Hee, Cheong, Keisuke, Furuhashi, Katsuki, Ito, Masato, Nagaoka, Takayuki, Yonezawa, Yutaka, Miura, Kazumi, Yagasaki   +6 more
openaire   +2 more sources

Muscle- and fibre type-specific expression of glucose transporter 4, glycogen synthase and glycogen phosphorylase proteins in human skeletal muscle

Pfl�gers Archiv European Journal of Physiology, 2004
The muscle- and fibre type-specific expression of skeletal muscle glucose transporter 4 (GLUT4), glycogen synthase (GS) and glycogen phosphorylase (GP) was investigated in six young male subjects. Single muscle fibres were dissected from vastus lateralis (VL), soleus (SO) and triceps brachii (TB) muscle biopsy samples.
Daugaard, J. R., Richter, Erik A.
openaire   +3 more sources

Effects of glipizide on glucose metabolism and muscle content of the insulin-regulatable glucose transporter (GLUT 4) and glycogen synthase activity during hyperglycaemia in type 2 diabetic patients

Acta Diabetologica, 1994
To examine whether sulphonylureas influence hyperglycaemia-induced glucose disposal and suppression of hepatic glucose production (HGP) in type 2 diabetes mellitus, a 150-min hyperglycaemic (plasma glucose 14 mmol/l) clamp with concomitant somatostatin infusion was used in eight type 2 diabetic patients before and after 6 weeks of glipizide (GZ ...
O, Schmitz, S, Lund, J F, Bak, L, Orskov, P H, Andersen, N, Møller, O, Rasmussen, J S, Christiansen, O, Pedersen   +8 more
openaire   +2 more sources

[Change of glucose transporter 4 and its influence on glucose and fatty-acid metabolism in type 2 diabetic myocardium].

Zhonghua yi xue za zhi, 2006
To investigate the relationship between sarcolemmal content of glucose transporter 4 (GLUT4) and the myocardial glucose and fatty acid utilization in type 2 diabetes.Twenty-four Sprague-Dawley rats were randomized into four groups: control, HFD/STZ, control/RSG and HFD/STZ/RSG.
Zhong-yuan, Wen, Yong, Wu, Yan, Li, Xiao-lin, Chen, Teng, Wang, Jing-ping, Ouyang, Geng-shan, Li   +6 more
openaire   +1 more source

Effects of Huanglian Jiedu Decoction on glucose transporter 4 in target tissues of type 2 diabetic rats

Journal of Chinese Integrative Medicine, 2007
OBJECTIVE To investigate the molecular mechanism of Huanglian Jiedu Decoction (HLJDD), a traditional Chinese compound herbal medicine, in treating type 2 diabetes mellitus (T2DM) by observing its effects on glucose transporter 4 (GLUT4) protein expression and translocation in adipose and skeletal muscle tissues of rats with T2DM.
openaire   +1 more source

Type 2 (non-insulin-dependent) diabetes mellitus and glucose transporter gene (GLUT 1 andGLUT 4) polymorphism

Acta Diabetologica, 1992
Glucose transporter genes have been proposed as candidate genes for type 2 (non-insulin-dependent) diabetes mellitus. We chose to study the adult skeletal muscle glucose transporter gene (GLUT 4) andGLUT 1 in consideration of previous conflicting results obtained by different authors.
C. Magnani, F. Capra, A. Calderara, P. A. Bonini, R. Taramelli, M. Ferrari, A. E. Pontiroli   +6 more
openaire   +1 more source

Effects of Chinese herbal medicine Yiqi Zengmin Formula on expression of glucose transporter 4 in skeletal muscle in type 2 diabetic rats

Journal of Chinese Integrative Medicine, 2011
To investigate the effects of traditional Chinese compound recipe Yiqi Zengmin (YQZM) formula on expression of glucose transporter 4 (GLUT4) in skeletal muscle of rats with type 2 diabetes induced by high-fat diet combined with low-dose-streptozotocin injection.Fifty male rats were randomly divided into two groups: model group fed with high-fat diet (n=
Hong-li, Xue, Zeng, Zhang, Wen-jian, Wang, Wei-hua, Chen, Jian, Ying   +4 more
openaire   +2 more sources

Combination therapy of sodium–glucose co-transporter-2 inhibitors and dipeptidyl peptidase-4 inhibitors in type 2 diabetes: rationale and evidences

Expert Review of Clinical Pharmacology, 2015
No single antidiabetic agent can correct all the pathophysiologic defects manifested in type 2 diabetes mellitus (T2DM) and, therefore, multiple agents are often required to achieve optimal glycemic control. Combination therapies, having different mechanisms of action, not only have the potential to complement their action, but may possess the ...
Awadhesh Kumar, Singh, Ritu, Singh
openaire   +2 more sources

Piceatannol, a resveratrol derivative, promotes glucose uptake through glucose transporter 4 translocation to plasma membrane in L6 myocytes and suppresses blood glucose levels in type 2 diabetic model db/db mice

Biochemical and Biophysical Research Communications, 2012
The skeletal muscle cells are one of the main sites of glucose uptake through glucose transporter 4 (GLUT4) in response to insulin. In muscle cells, 5' adenosine monophosphate-activated protein kinase (AMPK) is known as another GLUT4 translocation promoter.
Miki, Minakawa, Yutaka, Miura, Kazumi, Yagasaki   +2 more
openaire   +2 more sources