Results 91 to 100 of about 103,359 (263)

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Phlorotannins from Alaskan Seaweed Inhibit Carbolytic Enzyme Activity

Marine Drugs, 2014
Global incidence of type 2 diabetes has escalated over the past few decades, necessitating a continued search for natural sources of enzyme inhibitors to offset postprandial hyperglycemia.
Joshua Kellogg, Mary H. Grace, Mary Ann Lila   +2 more
doaj   +1 more source

Analysis of the α-glucosidase sequence.

, 2013
A. Alignment of amino acid sequences of α-glucosidase from R. prolixus (AgluRp), Culex quinquefasciatus (AGluCulex, AGluCulex2, AGluCulex3), α-amylase from Aedes aegypti (AmAeds), maltase-like Agm2 from Anopheles gambiae (MaltaseAgm2), maltase 2 from ...
Ligia Souza Ferreira (370709), Gonçalo Apolinário de Souza-Filho (370713), Olga Lima Tavares Machado (370720), Carlos Peres Silva (370718), José Roberto da Silva (370708), Viviane Veiga do Nascimento (370719), Marilvia Dansa-Petretski (370723), Flávia Borges Mury (370707), Jayme Augusto de Souza-Neto (370715), Paulo Eduardo Martins Ribolla (370717), Marília Amorim Berbert-Molina (370721), Beatriz dos Santos Ferreira (370711)   +11 more
core   +1 more source

Intestinal α-Glucosidase Inhibitors in Achillea millefolium [PDF]

, 2017
Achillea millefolium is a plant used as a component of anti-diabetic preparation but the bioactive compounds responsible for its use are not known. Inhibition of intestinal α-glucosidase is a preferable effect for prevention and treatment of diabetes ...
Kato, Eisuke, Noda, Kota, Kawabata, Jun
core   +1 more source

“Nature's Polymer Reimagined: Conventional and Green Routes to Pectin, Its Bioactive Promise and Industrial Applications”

Food Chemistry International, EarlyView.
Pectin, a versatile natural polymer, is extracted through conventional and emerging green extraction methods, offering multifunctional bioactive properties useful in food, pharmaceutical, and environmental applications. ABSTRACT Pectin, a molecular tapestry woven from diverse polysaccharides, holds a pivotal role across food, pharmaceutical, and ...
Afra Anika Rafique, Aunwesha Sahani, Md Morsaline Billah, Kazi Mohammed Didarul Islam   +3 more
wiley   +1 more source

Inhibitory Effects of Bioassay-Guided Isolation of Anti-Glycation Components from Taraxacum coreanum and Simultaneous Quantification

Molecules, 2018
Inhibition of the formation of advanced glycation end products (AGEs) is an attractive strategy in diabetes treatment. Taraxacum coreanum extracts were suggested to have antidiabetic effects. However, studies on the components of T. coreanum are lacking,
Kang Hee Lee, Wan Kyunn Whang
doaj   +1 more source

Nocodazole, a microtubule-active drug, interferes with apical protein delivery in cultured intestinal epithelial cells (Caco-2) [PDF]

, 1989
The polarized delivery of membrane proteins to the cell surface and the initial secretion of lysosomal proteins into the culture medium were studied in the polarized human intestinal adenocarcinoma cell line Caco-2 in the presence or absence of the ...
Hauri, H.P., Klumperman, J., Eilers, U., U Eilers, J Klumperman, Hauri, H. P., H P Hauri   +6 more
core   +2 more sources

Effect of Pretreatment Methods on the Proximate Composition, Antinutritional Factors, Antioxidants Properties, and In Vitro Antidiabetic Activities of Hypsizygus ulmarius

Food Chemistry International, EarlyView.
The effect of pretreatment methods on the proximate content, antinutrient factors, antioxidant, and in vitro antidiabetic activities of elm oyster mushroom was studied. It was observed and statistically concluded that soaking in 0.5% salt solution for 5 min had the least deteriorating effect on the antioxidant and in vitro antidiabetic activities ...
Oluwadamilola Ogunsade, Saka Olasunkanmi Gbadamosi, Tunde Afolabi Morakinyo, Adedayo Olubunmi Adeboye, Akinsola Albert Famuwagun   +4 more
wiley   +1 more source

Correction/Mutation of Acid Alpha-D-Glucosidase Gene by Modified Single- Stranded Oligonucleotides: In Vitro and in Vivo Studies

, 2009
Deficiency in acid alpha-D-glucosidase results in Pompe's disease. Modified single-stranded oligonucleotide (ODN) was designed to correct the acid alpha-D-glucosidase gene with a C1935-->A (Asp-->Glu) point mutation which causes a complete loss of ...
林淑萍, LIN, SHWU-BIN
core  

Impact of Sprouting and Brachystegia eurycoma Supplementation on the Functional, Proximate Composition, and Bioactive, Antioxidant, and Enzyme‐Inhibitory Properties of Sorghum Flour

Food Chemistry International, EarlyView.
Sprouting and Brachystegia eurycoma supplementation improved sorghum flour nutrition, antioxidant activity and enzyme inhibition for functional foods. ABSTRACT Sprouting and cereal–legume supplementation are effective strategies for improving the functional, nutritional, and nutraceutical qualities of cereal‐based flour and products.
Khadijat Oluwashola Abdulrazaaq, Emmanuel Anyachukwu Irondi, Emmanuel Oladipo Ajani   +2 more
wiley   +1 more source