Results 161 to 170 of about 41,118 (335)

Beyond nocardioform: Transcriptionally active microbes and host responses in equine mucoid placentitis

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background Nocardioform placentitis (NP) is an understudied form of equine placentitis historically attributed to nocardioform bacteria, yet it remains uncertain whether these organisms are the sole pathogens involved. Objectives To elucidate the pathophysiology of NP and the host–pathogen interaction. Study Design In vivo clinical multi‐omics
Machteld van Heule   +10 more
wiley   +1 more source

Reinventing henna: Enzyme‐catalysed colour release from stabilized Lawsonia inermis L. extracts

open access: yesInternational Journal of Cosmetic Science, EarlyView.
The instability and reduced dyeing performance of a cosmetic formulation containing 2‐hydroxy‐1,4‐naphthoquinone (lawsone), derived from Lawsonia inermis L., is demonstrated in comparison to a novel two‐component system. This system comprises one formulation with naturally occurring lawsone precursors and a second containing a specific hydrolase ...
Nele Dallmann   +2 more
wiley   +1 more source

Requirement of group I lytic polysaccharide monooxygenase for turnover of chitinous cuticle during moulting in two forest pest beetles, Monochamus alternatus and Psacothea hilaris

open access: yesInsect Molecular Biology, EarlyView.
Group I LPMO15‐1 cDNAs from two economically important forest insect pests, M. alternatus and P. hilaris, were cloned. MaLPMO15‐1 and PhLPMO15‐1 show a similar pattern of expression during late stages of development. RNAi for LPMO15‐1 causes failure of adult eclosion in both M. alternatus and P. hilaris.
Daehyeong Kim   +4 more
wiley   +1 more source

Lower glycemic status was associated with pancreatic cancer risk in prediabetes, but not in diabetes: A nationwide cohort study

open access: yesJournal of Diabetes Investigation, EarlyView.
In a nationwide Korean cohort of nearly 3 million adults, higher fasting blood glucose within the prediabetic range—but not glycemic control among people with diabetes—was associated with increased pancreatic cancer risk, highlighting the importance of optimal glucose control in nondiabetic populations.
Dong‐Hoe Koo   +3 more
wiley   +1 more source

Predictors of glycemic control with imeglimin for type 2 diabetes: Results of machine learning analyses using clinical trial data

open access: yesJournal of Diabetes Investigation, EarlyView.
Identifying patient characteristics predictive of treatment response is crucial for optimizing type 2 diabetes outcomes. Using data from three phase 2/3 imeglimin trials in Japan, this analysis applied machine learning to determine characteristics associated with HbA1c improvement.
Katsuhiko Hagi   +4 more
wiley   +1 more source

Epi-Cyclophellitol Cyclosulfate, a Mechanism-Based Endoplasmic Reticulum α-Glucosidase II Inhibitor, Blocks Replication of SARS-CoV-2 and Other Coronaviruses [PDF]

open access: diamond
Melissa Thaler   +18 more
openalex   +1 more source

Linderalactone mitigates diabetic renal injury by inhibiting macrophage inflammation via the Dectin1/Syk/CARD9/IRF5/NF‐κB pathway

open access: yesJournal of Diabetes Investigation, EarlyView.
ABSTRACT Background Inflammation plays an essential role in the pathogenesis of diabetic nephropathy (DN). Linderalactone (LNL), as a natural sesquiterpene lactone, has been discovered to have anti‐inflammatory activation. However, the effects of linderalactone on diabetes‐associated renal damage remain unclear.
Hao Chen   +7 more
wiley   +1 more source

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