Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential [PDF]
, 2015 Autophagy is a conserved homeostatic process active in all human cells and affecting a spectrum of diseases. Here we use a pharmaceutical screen to discover new mechanisms for activation of autophagy.
Ahmed, Zahra +16 more
core +3 more sources
Glucocerebrosidase deficiency leads to neuropathology via cellular immune activation.
PLoS GeneticsMutations in GBA (glucosylceramidase beta), which encodes the lysosomal enzyme glucocerebrosidase (GCase), are the strongest genetic risk factor for the neurodegenerative disorders Parkinson's disease (PD) and Lewy body dementia.
Evelyn S Vincow +6 more
doaj +1 more source
Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A [PDF]
, 2018 Chaperone-mediated autophagy (CMA) is a selective degradative process for cytosolic proteins that contributes to the maintenance of proteostasis. The signaling mechanisms that control CMA are not fully understood but might involve response to stress ...
Arias, Esperanza +5 more
core +3 more sources
PLoS ONE, 2015 Gaucher disease is characterized by lysosomal accumulation of glucosylceramide due to deficient activity of lysosomal glucocerebrosidase (GBA). In cells, glucosylceramide is also degraded outside lysosomes by the enzyme glucosylceramidase 2 (GBA2) of ...
Daniela Herrera Moro Chao +16 more
doaj +1 more source
Delineating pathological pathways in a chemically-induced mouse model of Gaucher disease [PDF]
, 2016 Great interest has been shown in understanding the pathology of Gaucher disease (GD), due to the recently discovered genetic relationship with Parkinson's disease. For such studies, suitable animal models of GD are required.
Eilam, R +11 more
core +1 more source
Cell wall degrading enzymes in Trichoderma asperellum grown on wheat bran [PDF]
, 2015 Trichoderma asperellum is a filamentous fungus that is able to produce and secrete a wide range of extracellular hydrolytic enzymes used for plant cell wall degradation.
Bech, Lasse +2 more
core +2 more sources
Autophagic lysosome reformation dysfunction in glucocerebrosidase deficient cells: relevance to Parkinson disease. [PDF]
, 2016 Glucocerebrosidase (GBA1) gene mutations increase the risk of Parkinson disease (PD). While the cellular mechanisms associating GBA1 mutations and PD are unknown, loss of the glucocerebrosidase enzyme (GCase) activity, inhibition of autophagy and ...
Doherty, MK +5 more
core +2 more sources
Ruthenibacterium lactatiformans gen. nov., sp.nov., an anaerobic, lactate-producing member of the family Ruminococcaceae isolated from human faeces [PDF]
, 2016 Two novel strains of Gram-stain-negative, rod-shaped, obligately anaerobic, non-spore-forming, non-motile bacteria were isolated from the faeces of healthy human subjects.
Bozhenko, Vladimir K. +6 more
core +1 more source
Xylan degrading enzymes from fungal sources [PDF]
, 2015 Fungi have the ability to degrade xylan as the major component of plant cell wall hemicellulose. Fungi have evolved batteries of xylanolytic enzymes that concertedly act to depolymerise xylan backbones decorated with variable carbohydrate branches. As an
Connerton, Ian F., Kirikyali, N.
core +2 more sources
Microbial β-Glucosidase: sources, production and applications [PDF]
, 2017 Cellulose is the most abundant biopolymer in biosphere and the major constituent of plant biomass. Cellulose polymer is made up of β-glucose units linked by β-glucosidic bonds. Cellulase is an enzymatic system that catalyzes the hydrolysis of cellulose
Ahmed, Amer +3 more
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