Results 81 to 90 of about 3,930 (214)
Glucocerebrosidase deficiency promotes protein aggregation through dysregulation of extracellular vesicles. [PDF]
PLoS Genetics, 2018 Mutations in the glucosylceramidase beta (GBA) gene are strongly associated with neurodegenerative diseases marked by protein aggregation. GBA encodes the lysosomal enzyme glucocerebrosidase, which breaks down glucosylceramide.
Ruth E Thomas +5 more
doaj +1 more source
SrfJ, a salmonella type III secretion system effector regulated by PhoP, RcsB, and IolR. [PDF]
, 2012 Virulence-related type III secretion systems are present in many Gram-negative bacterial pathogens. These complex devices translocate proteins, called effectors, from the bacterium into the eukaryotic host cell. Here, we identify the product of srfJ, a
Bernal Bayard, Joaquín +2 more
core +1 more source
Plant Biotechnology Journal, Volume 24, Issue 1, Page 256-272, January 2026.ABSTRACT Plant systems have gained increased attention as an alternative platform for producing heterologous proteins, particularly for industrially relevant proteins. The Cynara cardunculus L. flower extract is traditionally used in cheese production across Mediterranean countries due to its milk‐clotting properties.
Saraladevi Muthusamy +8 more
wiley +1 more source
Differential Quantitative Proteomics of Human Microvascular Endothelial Cells 1 by iTRAQ Reveals Palladin to be a New Biomarker During TGF-β1 Induced Endothelial Mesenchymal Transition [PDF]
, 2017 The study uses global quantitative proteomics to investigate the molecular mechanisms behind the induction of endothelial-mesenchymal transition (EndMT) by transforming growth factor–β (TGF-β).
Bednarek, Radosław +7 more
core +1 more source
Plant Biotechnology Journal, Volume 24, Issue 1, Page 187-203, January 2026.ABSTRACT Plants are promising next‐generation hosts for recombinant protein production; however, major challenges remain with regard to enhancing the efficiency of downstream processing, particularly in the removal of cellular residues and purification of the expressed proteins.
Hiroyuki Kajiura +3 more
wiley +1 more source
Neurobiology of Disease, 2022 Preclinical and clinical studies support a strong association between mutations in the GBA1 gene that encodes beta-glucocerebrosidase (GCase) (EC 3.2.1.45; glucosylceramidase beta) and Parkinson's disease (PD).
Alexia Polissidis +9 more
doaj +1 more source
Progress of non‐motor symptoms in early‐onset Parkinson's disease
Ibrain, Volume 11, Issue 4, Page 422-438, Winter 2025.This study reviews the research progress related to non‐motor symptoms (NMS) in patients with early onset Parkinson's disease (EOPD), including neuropsychiatric symptoms, autonomic dysfunction, sleep disorders, and sensory disorders and also summarizes the characteristics of NMS in the genetic form of Parkinson's disease (PD).
Fanshi Zhang +5 more
wiley +1 more source
1-O-acylceramides are natural components of human and mouse epidermis[S]
Journal of Lipid Research, 2013 The lipid-rich stratum corneum functions as a barrier against pathogens and desiccation inter alia by an unbroken meshwork of extracellular lipid lamellae.
Mariona Rabionet +9 more
doaj +1 more source
Genome-Wide Expression Analysis in Drosophila Reveals Genes Controlling Circadian Behavior [PDF]
, 2002 In Drosophila, a number of key processes such as emergence from the pupal case, locomotor activity, feeding, olfaction, and aspects of mating behavior are under circadian regulation.
Ceriani, Maria Fernanda +5 more
core +1 more source
MedComm – Oncology, Volume 4, Issue 4, December 2025.Parkinson's disease (PD) and glioma are neurological disorders with distinct and even opposing mechanisms: α‐synuclein deposition and neuronal loss in PD versus glial cell malignancy in glioma. Despite these differences, their contrasting pathologies highlight multiple therapeutic targets.
Tianli Pan +7 more
wiley +1 more source