Results 11 to 20 of about 1,898 (179)
Гинекология, 2023 Aim. To determine the change of lipid levels in the cervical epithelial cells during the treatment of chronic cervicitis and low-grade squamous intraepithelial lesions (LSIL) with 0.1% activated glycyrrhizic acid. Materials and methods.
Alisa O. Tokareva +10 more
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Characterization of Scedosporium apiospermum glucosylceramides and their involvement in fungal development and macrophage functions. [PDF]
PLoS ONE, 2014 Scedosporium apiospermum is an emerging fungal pathogen that causes both localized and disseminated infections in immunocompromised patients. Glucosylceramides (CMH, GlcCer) are the main neutral glycosphingolipids expressed in fungal cells. In this study,
Rodrigo Rollin-Pinheiro +4 more
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Targeted lipidomics reveals a novel role for glucosylceramides in glucose response
Journal of Lipid Research, 2023 The addition of excess glucose to the diet drives a coordinated response of lipid metabolism pathways to tune the membrane composition to the altered diet.
Mark A. Xatse +3 more
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Property-based design of a glucosylceramide synthase inhibitor that reduces glucosylceramide in the brain [PDF]
Journal of Lipid Research, 2012 Synthesis inhibition is the basis for the treatment of type 1 Gaucher disease by the glucosylceramide synthase (GCS) inhibitor eliglustat tartrate. However, the extended use of eliglustat and related compounds for the treatment of glycosphingolipid storage diseases with CNS manifestations is limited by the lack of brain penetration of this drug ...
Scott D. Larsen +9 more
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Sphingolipid metabolism during epidermal barrier development in mice
Journal of Lipid Research, 2002 In rodents, a competent skin barrier to water loss is formed within 2 or 3 days prior to birth. Acquisition of barrier function during rat gestation correlates with the formation of a stratum corneum enriched in ceramides, cholesterol, and fatty acids ...
Thomas Doering +2 more
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The fate and function of glycosphingolipid glucosylceramide [PDF]
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2003 In higher eukaryotes, glucosylceramide is the simplest member and precursor of a fascinating class of membrane lipids, the glycosphingolipids. These lipids display an astounding variation in their carbohydrate head groups, suggesting that glycosphingolipids serve specialized functions in recognition processes. It is now realized that they are organized
van Meer, G. +2 more
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Glucosylceramides of pig epidermis: structure determination.
Journal of Lipid Research, 1983 Six series of glucosylceramides from pig epidermis have been identified, and their structures have been determined. The structural types identified are: 1, N-acylglucosylsphingosines (33%); 2, N-acylglucosylphytosphingosines (13%); 3, N-(omega ...
P W Wertz, D T Downing
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The role of glucosylceramide and glucosylceramide synthase in liver disease: from bench to bedside
Acta Biochimica Polonica, 2020 The cell membrane, which is lipid-rich, is not only a simple mechanical barrier but also an important and complex component of the cell. It also communicates with the external environment. Sphingomyelin is an important class of phospholipids in the membrane that performs many functions.
Jian Gan +3 more
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Improved Inhibitors of Glucosylceramide Synthase [PDF]
Journal of Biological Chemistry, 1999 Previous work has led to the identification of inhibitors of glucosylceramide synthase, the enzyme catalyzing the first glycosylation step in the synthesis of glucosylceramide-based glycosphingolipids. These inhibitors have two identified sites of action: the inhibition of glucosylceramide synthase, resulting in the depletion of cellular ...
L, Lee, A, Abe, J A, Shayman
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Uptake by neuroblastoma cells of glucosylceramide, glucosylceramide glucosidase, its stimulator protein, and phosphatidylserine [PDF]
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1986 Serum-free cultured neuroblastoma cells (clone NlE-115) have been shown to absorb emulsified glucosylceramide, glucosylceramide glucosidase, an activator protein for the enzyme, and phosphatidylserine from a synthetic medium. Uptake of the enzyme was augmented by phosphatidylserine, and vice versa.
Datta, Subhash C. +2 more
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