Results 21 to 30 of about 1,898 (179)

Glycosphingolipids and neuroinflammation in Parkinson’s disease

Molecular Neurodegeneration, 2020
Parkinson's disease is a progressive neurodegenerative disease characterized by the loss of dopaminergic neurons of the nigrostriatal pathway and the formation of neuronal inclusions known as Lewy bodies.
Karim Belarbi, Elodie Cuvelier, Marie-Amandine Bonte, Mazarine Desplanque, Bernard Gressier, David Devos, Marie-Christine Chartier-Harlin   +6 more
doaj   +1 more source

Glucosylceramide flippases contribute to cellular glucosylceramide homeostasis

Journal of Lipid Research
Lipid transport is an essential cellular process with importance to human health, disease development, and therapeutic strategies. Type IV P-type ATPases (P4-ATPases) have been identified as membrane lipid flippases by utilizing nitrobenzoxadiazole (NBD)-labeled lipids as substrates.
Natsuki Kita, Asuka Hamamoto, Siddabasave Gowda B. Gowda, Hiroyuki Takatsu, Kazuhisa Nakayama, Makoto Arita, Shu-Ping Hui, Hye-Won Shin   +7 more
openaire   +4 more sources

Glucosylceramide synthase activity in murine epidermis: quantitation, localization, regulation, and requirement for barrier homeostasis

Journal of Lipid Research, 1998
Ceramides, which derive from the hydrolysis of glucosylceramide (GlcCer), are the predominant lipid species in the stratum corneum and are critical for epidermal permeability barrier homeostasis. UDP-glucose:ceramide glucosyltransferase (GlcCer synthase)
Chujor S.N. Chujor, Kenneth R. Feingold, Peter M. Elias, Walter M. Holleran   +3 more
doaj   +1 more source

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl‐Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies

Angewandte Chemie, EarlyView.
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster, Òscar Vidal‐Gironès, Rowan de Graaf, Ken Kok, Lindsey T. Lelieveld, Jackelien Hoogervorst, Maria J. Ferraz, José Pablo Rivas‐Fernández, Rob F. Lammers, Herman S. Overkleeft, Johannes M. F. G. Aerts, Rolf G. Boot, Carme Rovira, Marta Artola   +13 more
wiley   +2 more sources

Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury

Journal of Lipid Research, 2017
Acute kidney injury (AKI), resulting from chemotherapeutic agents such as cisplatin, remains an obstacle in the treatment of cancer. Cisplatin-induced AKI involves apoptotic and necrotic cell death, pathways regulated by sphingolipids such as ceramide ...
Tess V. Dupre, Mark A. Doll, Parag P. Shah, Cierra N. Sharp, Deanna Siow, Judit Megyesi, James Shayman, Alicja Bielawska, Jacek Bielawski, Levi J. Beverly, Maria Hernandez-Corbacho, Christopher J. Clarke, Ashley J. Snider, Rick G. Schnellmann, Lina M. Obeid, Yusuf A. Hannun, Leah J. Siskind   +16 more
doaj   +1 more source

Loss of glucosylceramide synthase impairs the growth and virulence of Fusarium oxysporum f. sp. cubense

Phytopathology Research, 2022
Glucosylceramides are a class of membrane lipids that serve as vital structural and signaling molecules in eukaryotes. In this study, we explored the function of FocGCS, a glucosylceramide synthase (GCS) in Fusarium oxysporum f. sp. cubense tropical race
Jian Wang, Kun Zhang, Li-Qun Huang, He-Nan Bao, Na Hai, Yu-Bing Yang, Si-Wen Liu, Chun-Yu Li, Nan Yao   +8 more
doaj   +1 more source

Fungal glucosylceramides: from structural components to biologically active targets of new antimicrobials

Frontiers in Microbiology, 2011
The first work reporting synthesis of glucosylceramide (cerebrin, GlcCer) by yeasts was published in 1930. During approximately 70 years members of this class of glycosphingolipids (GSL) were considered merely structural components of plasma membrane in ...
Leonardo eNimrichter, Marcio Lourenço Rodrigues   +1 more
doaj   +1 more source

Sitosterol and glucosylceramide cooperative transversal and lateral uneven distribution in plant membranes

Scientific Reports, 2021
The properties of biomembranes depend on the presence, local structure and relative distribution assumed by the thousands of components it is made of.
V. Rondelli, A. Koutsioubas, J. Pršić, E. Deboever, J. M. Crowet, L. Lins, M. Deleu   +6 more
doaj   +1 more source

Highly efficient preparation of sphingoid bases from glucosylceramides by chemoenzymatic method[S]

Journal of Lipid Research, 2016
Sphingoid base derivatives have attracted increasing attention as promising chemotherapeutic candidates against lifestyle diseases such as diabetes and cancer. Natural sphingoid bases can be a potential resource instead of those derived by time-consuming
Siddabasave Gowda B. Gowda, Seigo Usuki, Mostafa A.S. Hammam, Yuta Murai, Yasuyuki Igarashi, Kenji Monde   +5 more
doaj   +1 more source

The Host Immune Response to Scedosporium/Lomentospora

Journal of Fungi, 2021
Infections caused by the opportunistic pathogens Scedosporium/Lomentospora are on the rise. This causes problems in the clinic due to the difficulty in diagnosing and treating them.
Idoia Buldain, Leire Martin-Souto, Aitziber Antoran, Maialen Areitio, Leire Aparicio-Fernandez, Aitor Rementeria, Fernando L. Hernando, Andoni Ramirez-Garcia   +7 more
doaj   +1 more source