Results 31 to 40 of about 1,898 (179)

Glucosylceramide acyl chain length is sensed by the glycolipid transfer protein.

PLoS ONE, 2018
The glycolipid transfer protein, GLTP, can be found in the cytoplasm, and it has a FFAT-like motif (two phenylalanines in an acidic tract) that targets it to the endoplasmic reticulum (ER).
Anders P E Backman, Josefin Halin, Henrik Nurmi, Anna Möuts, Matti A Kjellberg, Peter Mattjus   +5 more
doaj   +1 more source

Antiviral activity of glucosylceramides isolated from Fusarium oxysporum against Tobacco mosaic virus infection.

PLoS ONE, 2020
Natural elicitors derived from pathogenic microorganisms represent an ecologic strategy to achieve resistance in plants against diseases. Glucosylceramides (GlcCer) are classified as neutral glycosphingolipids.
Mariana C Bernardino, Michel Leon C O Couto, Maite F S Vaslin, Eliana Barreto-Bergter   +3 more
doaj   +1 more source

Age-dependent changes in the sphingolipid composition of mouse CD4+ T cell membranes and immune synapses implicate glucosylceramides in age-related T cell dysfunction. [PDF]

PLoS ONE, 2012
To determine whether changes in sphingolipid composition are associated with age-related immune dysfunction, we analyzed the core sphingolipidome (i.e., all of the metabolites through the first headgroup additions) of young and aged CD4(+) T cells. Since
Alberto Molano, Zhaofeng Huang, Melissa G Marko, Angelo Azzi, Dayong Wu, Elaine Wang, Samuel L Kelly, Alfred H Merrill, Stephen C Bunnell, Simin Nikbin Meydani   +9 more
doaj   +1 more source

Acylglucosylceramides of pig epidermis: structure determination

Journal of Lipid Research, 1983
The acylglucosylceramides of pig epidermis comprise 56% of the total glucosylceramides and 3.3% of the total epidermal lipid by weight. Contrary to an earlier report on this lipid, the amide-linked fatty acid is not a dihydroxypentatriacontadienoic acid;
P W Wertz, D T Downing
doaj   +1 more source

4,8-Sphingadienine and 4-hydroxy-8-sphingenine activate ceramide production in the skin

Lipids in Health and Disease, 2012
Background Ingestion of glucosylceramide improves transepidermal water loss (TEWL) from the skin, but the underlying mechanism by which a small amount of dietary glucosylceramide can vastly improve skin conditions remains unclear.
Shirakura Yoshiyuki, Kikuchi Kanako, Matsumura Kenji, Mukai Katsuyuki, Mitsutake Susumu, Igarashi Yasuyuki   +5 more
doaj   +1 more source

Dysregulated metabolism of ceramides and glycosphingolipids in Parkinson’s disease

Journal of Lipid Research
Alterations in sphingolipid metabolism have been implicated in the pathogenesis of Parkinson's disease (PD), yet findings regarding peripheral sphingolipid changes remain inconsistent.
Yu-Fong Peng, Szu-Ju Chen, Jeng-Lin Li, Chin-Hsien Lin, Ching-Hua Kuo   +4 more
doaj   +1 more source

Comparative metabolomic profiling of women undergoing in vitro fertilization procedures reveals potential infertility-related biomarkers in follicular fluid

Scientific Reports, 2022
Infertility is a worldwide concern, affecting one in six couples throughout their reproductive period. Therefore, enhancing the clinical tools available to identify the causes of infertility may save time, money, and emotional distress for the involved ...
Mohamed Ziad Dabaja, Aline Amaro dos Santos, Denise Maria Christofolini, Caio Parente Barbosa, Diogo Noin de Oliveira, Arthur Noin de Oliveira, Carlos Fernando Odir Rodrigues Melo, Tatiane Melina Guerreiro, Rodrigo Ramos Catharino   +8 more
doaj   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

A gut microbiome‐lipid axis in early pregnancy is associated with metabolic dysregulation and diabetes risk

iMeta, EarlyView.
Early‐pregnancy microbiome and lipidome profiling identified a microbiome‐glycosphingolipid axis associated with later gestational diabetes mellitus (GDM) risk. In the prospective pregnancy cohort, women who later developed GDM showed altered gut microbial composition, enriched microbial lipid biosynthesis pathways, and broad plasma lipidomic changes ...
Zhonghan Sun, Chang He, Xiaonan Ma, Ping Wu, Tianlei Wang, Jiaying Yuan, Yanni Pu, Xiaofeng Zhou, Zhendong Mei, Huiling Song, Yetong Wang, Haiyan Yue, Yuanqing Fu, Jusheng Zheng, An Pan, Da Chen, Shangyu Hong, Xiong‐Fei Pan, Yan Zheng   +18 more
wiley   +1 more source

Effect of Expression of Human Glucosylceramidase 2 Isoforms on Lipid Profiles in COS-7 Cells

Metabolites, 2020
Glucosylceramide (GlcCer) is a major membrane lipid and the precursor of gangliosides. GlcCer is mainly degraded by two enzymes, lysosomal acid β-glucosidase (GBA) and nonlysosomal β-glucosidase (GBA2), which may have different isoforms because of ...
Peeranat Jatooratthawichot, Chutima Talabnin, Lukana Ngiwsara, Yepy Hardi Rustam, Jisnuson Svasti, Gavin E. Reid, James R. Ketudat Cairns   +6 more
doaj   +1 more source