Results 41 to 50 of about 2,015 (206)

Zinc Treatment Reverses and anti-Zn-Regulated miRs Suppress Esophageal Carcinomas In Vivo [PDF]

open access: yes, 2023
Esophageal squamous cell carcinoma (ESCC) is a deadly disease with few prevention or treatment options. ESCC development in humans and rodents is associated with Zn deficiency (ZD), inflammation, and overexpression of oncogenic microRNAs: miR-31 and miR ...
Brydges, Christopher R   +7 more
core   +1 more source

Charge neutralization and β-elimination cleavage mechanism of family 42 L-rhamnose-α-1,4-D-glucuronate lyase revealed using neutron crystallography [PDF]

open access: gold, 2022
Naomine Yano   +6 more
openalex   +1 more source

Intervertebral Disc Proteoglycans: Multifunctional Tissue Stabilizing and Instructional Cell Regulatory Proteins That Control Tissue Homeostasis

open access: yesJOR SPINE, Volume 8, Issue 4, December 2025.
Matrix and cell‐associated proteoglycans are important tissue‐stabilizing, weight‐bearing, and tension‐resisting proteins in the intervertebral disc. Their glycosaminoglycan components have growth factor binding and cell‐instructive properties that allow cells to regulate tissue composition and function.
James Melrose
wiley   +1 more source

Sex‐Specific Lasting Metabolome Effects of Adverse Gestational Conditions and Prevention by Myo‐Inositol Supplementation During Suckling

open access: yesMolecular Nutrition &Food Research, Volume 69, Issue 23, December 2025.
This graphical abstract illustrates the effects of myo‐inositol supplementation during suckling in reducing long‐term metabolic impacts from mild gestational calorie restriction (GCR). Using a metabolomics approach, 164 metabolites were identified, with greater metabolic alterations in males.
Rocío A. Martín‐Chamorro   +6 more
wiley   +1 more source

Unveiling the Potential of Lentilactobacillus hilgardii in Malolactic Fermentation: Comparative Genomics and Fermentation Dynamics

open access: yesMicrobial Biotechnology, Volume 18, Issue 12, December 2025.
This study explores the metabolic potential of Lentilactobacillus hilgardii for malolactic fermentation in winemaking. Genomic and in silico analyses, combined with experimental validation, reveal its resilience at low temperatures and unique enzymatic traits. Comparative insights with Oenococcus oeni highlight L.
Giacomo Mantegazza   +5 more
wiley   +1 more source

Transcriptomic and enzymological evidence for plastid peptidoglycan synthesis in the gymnosperm Picea abies

open access: yesThe Plant Journal, Volume 124, Issue 5, December 2025.
Significance Statement Peptidoglycan (murein) biosynthesis is involved in chloroplast division in mosses, while Arabidopsis MurE mutants are defective in chloroplast development. We have shown that the gymnosperm Picea abies expresses 11 genes of the peptidoglycan biosynthesis pathway, and that P.
Yayoi Sugita   +11 more
wiley   +1 more source

Classification of Clinical Isolates of Klebsiella pneumoniae Based on Their in vitro Biofilm Forming Capabilities and Elucidation of the Biofilm Matrix Chemistry With Special Reference to the Protein Content [PDF]

open access: yes, 2019
Klebsiella pneumoniae is a human pathogen, capable of forming biofilms on abiotic and biotic surfaces. The limitations of the therapeutic options against Klebsiella pneumoniae is actually due to its innate capabilities to form biofilm and harboring ...
Ashish Kumar Singh   +10 more
core   +1 more source

New analytical methodologies for doping control – detection of anabolic androgenic steroids in human urine [PDF]

open access: yes, 2011
Dissertation submitted to Faculdade de Ciências e Tecnologia - Universidade Nova de Lisboa in fulfilment of the requirements for the degree of Doctor of Philosophy (Biochemistry - Biotechnology)The use of anabolic androgenic steroids (AAS) and other ...
Galésio, Marco André Miranda
core  

Phase III biotransformation enzyme involvement in the ovarian response to ovotoxic environmental exposures [PDF]

open access: yes, 2016
The mammalian ovary is comprised of follicles at various stages of growth and is responsible for gamete and steroid hormone production. Conservation of ovarian function is vital for female reproductive and general health, and disruption can lead to ...
Thomas, Porsha Q.
core   +3 more sources

Some Cytological Effects of Glucuronic Acid, Na-glucuronate, Glucuronic Amide, and Pyridoxal Phosphate on Tumor Cells

open access: yesThe Japanese Journal of Genetics, 1963
腫瘍細胞におよぼす glucuronic acid, Na-glucuronate, glucuronic amide および pyridoxal phosphate の影響を MTK 肉腫-III, エールリッヒ腹水癌および HeLa 細胞を用いて in vivo と in vitro で観察した。腫瘍細胞はいずれの薬物処理においても顕著な異常は示さなかった。また, 処理動物の生存日数は対照群と大差なかった。高濃度処理の場合にのみ, 細胞の分裂頻度がわずかながら増大し, HeLa 細胞の細胞質内にグリコーゲンと推定される微少顆粒が一時的に出現するのが観察された。
openaire   +2 more sources

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