Vaginal Microbiota and Ovarian Cancer: A New Frontier in Immunomodulation and Diagnosis
Immunology, EarlyView.Microbial imbalance, dysbiosis, plays a role in ovarian carcinogenesis by interacting with the immune system and altering inflammatory pathways, notably Th17 pathways. In contrast, eubiosis, characterised by Lactobacillus dominance, protects against infections and maintains hormone metabolism.
Wafa Babay +4 more
wiley +1 more source
Systematic mutational analysis of the cation-independent mannose 6-phosphate/insulin-like growth factor II receptor cytoplasmic domain - An acidic cluster containing a key aspartate is important for function in lysosomal enzyme sorting [PDF]
, 1997 We have used systematic mutational analysis to identify signals in the 166-residue murine cation-independent mannose 6-phosphate/insulin-like growth factor II receptor cytoplasmic domain required for efficient sorting of lysosomal enzymes.
Chen, Hong Jung +2 more
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A Doxorubicin-Glucuronide Prodrug Released from Nanogels Activated by High-Intensity Focused Ultrasound Liberated β-Glucuronidase [PDF]
, 2020 Helena C. Besse +7 more
openalex +1 more source
Journal of Fish Diseases, EarlyView.ABSTRACT Lactococcus garvieae, Lactococcus petauri and Lactococcus formosensis are etiological agents of piscine lactococcosis, a disease reported in Italy since the early 1990s and linked to significant aquaculture losses. To the best of our knowledge, this study reports the first detection of L. formosensis subsp. formosensis in farmed rainbow trout (
Silvia Colussi +12 more
wiley +1 more source
The Hepatocellular Hypoxia Criteria:2’Nitroimidazole Effect on Hepatocyte Carbohydrate Metabolizing Enzymes [PDF]
, 2008 Aim: to understand the 2’-nitroimidazole induced hypoxia and liver cell interaction, we proposed a “Hapatocellular Hypoxia Criteria”.
Rakesh Sharma
core +1 more source
Journal of Biological Chemistry, 2013 Background: The structure of GH115 glucuronidases that remove glucuronic acid from xylan chains is unknown. Results: Bacteroides ovatus GH115 glucuronidase is a dimeric enzyme that contains a flexible active site pocket.
A. Rogowski +7 more
semanticscholar +1 more source
Journal of Integrative Plant Biology, EarlyView.During strawberry ripening, abscisic acid signaling activates SnRK2.6, which phosphorylates and degrades the JAZ12 repressor. This releases the MYC2 transcription factor, directly activating jasmonic acid biosynthesis genes. The resulting jasmonic acid accumulation drives aroma production, thereby coupling ripening with scent formation through this ...
Kenan Jia +10 more
wiley +1 more source
Synthesis of Chromen-4-One-Oxadiazole Substituted Analogs as Potent β-Glucuronidase Inhibitors
Molecules, 2019 Chromen-4-one substituted oxadiazole analogs 1–19 have been synthesized, characterized and evaluated for β-glucuronidase inhibition. All analogs exhibited a variable degree of β-glucuronidase inhibitory activity with IC50 values ranging ...
Muhammad Taha +10 more
doaj +1 more source
Use of the KlADH4 promoter for ethanol-dependent production of recombinant human serum albumine in Kluyveromyces lactis [PDF]
, 1999 KlADH4 is a gene of Kluyveromyces lactis encoding a mitochondrial alcohol dehydrogenase activity which is specifically induced by ethanol. The promoter of this gene was used for the expression of heterologous proteins in K.
CRISA A. +6 more
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In vitro metabolic studies of REV-ERB agonists SR9009 and SR9011 [PDF]
, 2016 SR9009 and SR9011 are attractive as performance-enhancing substances due to their REV-ERB agonist effects and thus circadian rhythm modulation activity.
Deventer, Koen +4 more
core +3 more sources