Results 71 to 80 of about 32,088 (220)

Molecular Insights Into β‐Glucuronidase Inhibition by Alhagi Graecorum Flavonoids: A Computational and Experimental Approach

ChemistryOpen
In this study, we aimed to investigate the inhibitory mechanisms of β‐glucuronidase by flavonoids derived from Alhagi graecorum through both experimental and computational approaches.
Dr. Emadeldin M. Kamel, Saleh Maodaa, Esam M. Al‐Shaebi, Al Mokhtar Lamsabhi   +3 more
doaj   +1 more source

From Phenolic Profile to Gut Function: Comparative Effects of Region-Specific Shilajit on Selected Culturable Intestinal Microbial Groups and β-Glucuronidase Activity—A Preliminary Study

Molecules
Shilajit is a complex natural phytomineral substance whose composition and biological activity may vary depending on geographical origin. This study compared three commercially available Shilajit samples from Russia (S1), Nepal (S2), and Iran (S3) in ...
Elham Kamgar, Małgorzata Gumienna, Barbara Górna-Szweda, Miroslava Kačániová, Przemysław Łukasz Kowalczewski, Joanna Zembrzuska   +5 more
doaj   +1 more source

Application of sonication-assisted Agrobacterium-mediated transformation in Chenopodium rubrum L

Plant, Soil and Environment, 2003
Chenopodium rubrum belongs to the plant species in which standard Agrobacterium-mediated transformation procedures remain inefficient. We demonstrate that the employment of sonication-assisted Agrobacterium-mediated transformation (SAAT) effectively ...
J.I. Flores Solís, P. Mlejnek, K. Studená, S. Procházka   +3 more
doaj   +1 more source

Arabidopsis inositol polyphosphate kinase activities regulate COP9 deneddylation functions in phosphate homeostasis

Journal of Integrative Plant Biology, EarlyView.
Plant phosphate (Pi) homeostasis relies on coordinated activities of the inositol polyphosphate kinases IPK1 and ITPK1, which balance localized InsP7 biosynthesis to control COP9 signalosome (CSN)‐dependent deneddylation of cullin 1 (CUL1). Perturbation of this equilibrium affects the stability of SPX4, a key negative regulator of phosphate starvation ...
Yashika Walia, Medha Noopur, Ishana Bhattacharya, Bhaskar Chandra Sahoo, Mritunjay Kasera, Naga Jyothi Pullagurla, Smritikana Dutta, Guizhen Liu, Gabriel Schaaf, Henning Jessen, Debabrata Laha, Souvik Bhattacharjee, Saikat Bhattacharjee   +12 more
wiley   +1 more source

Inhibitory Effects of Baicalein Derived from Japanese Traditional Herbal Medicine on SN-38 Glucuronidation

Journal of Pharmacy & Pharmaceutical Sciences, 2018
Purpose: The chemotherapeutic agent irinotecan is hydrolyzed to its active form SN-38 by human carboxyesterases, but SN-38 is converted into the inactive form SN-38G by hepatic UDP-glucuronosyltransferases (UGTs).
Takashi Satoh, Ayaka Igarashi, Misaki Tanno, Koki Yamada, Natsuko Takahashi-Suzuki, Kazuhiro Watanabe   +5 more
doaj   +1 more source

Dodder seedlings benefit from apoplastic nutrition by inducing SWEET15‐mediated unloading of sucrose from the host's phloem

New Phytologist, EarlyView.
Cuscuta reflexa infection sites. Summary Cuscuta species are holoparasitic plants that penetrate host stems with haustoria, connect to the vasculature and exhaust water, nutrients and carbohydrates. Parasite seedlings possess only limited maternal reserves and the development of a vascular connection takes several days.
Maleen Hartenstein, Dominik Eydam, Antonia Klatt, Arne Greif, Peter Slaby, Ronja Burggraf, Franz Klebl, Isabell Albert, Uwe Sonnewald, Ruth Stadler, Markus Albert   +10 more
wiley   +1 more source

Fecal microbial determinants of fecal and systemic estrogens and estrogen metabolites: a cross-sectional study

Journal of Translational Medicine, 2012
Background High systemic estrogen levels contribute to breast cancer risk for postmenopausal women, whereas low levels contribute to osteoporosis risk. Except for obesity, determinants of non-ovarian systemic estrogen levels are undefined.
Flores Roberto, Shi Jianxin, Fuhrman Barbara, Xu Xia, Veenstra Timothy D, Gail Mitchell H, Gajer Pawel, Ravel Jacques, Goedert James J   +8 more
doaj   +1 more source

Turnip mosaic virus utilizes the lipid droplet biogenesis machinery to facilitate its propagation in plants

New Phytologist, EarlyView.
Potyvirus turnip mosaic virus induces neutral lipid accumulation and lipid droplet biogenesis in infected leaves for its own benefit. Summary Lipid droplets (LDs), which are dedicated to storing neutral lipids (NLs), are dynamic organelles involved in numerous other functions, including membrane remodeling during abiotic stress.
Léna Jambou, Nathalie Arvy, Marguerite Batsale, Luc Sofer, Sara Shakir, Marielle Cochet, Vincent Simon, Charlotte Quinteau, Thomas Scotti, Nathan M. Doner, Satinder K. Gidda, Robert T. Mullen, Sabine D'Andréa, Jean‐Luc Gallois, Denis Coulon, Claire Bréhélin, Sylvie German‐Retana   +16 more
wiley   +1 more source

Knocking Out Two Polyphenol Oxidase Genes Significantly Improves Recombinant Protein Purification in Nicotiana benthamiana

Plant Biotechnology Journal, EarlyView.
ABSTRACT Efficient purification remains a key technical challenge affecting the recovery efficiency of recombinant proteins in plant‐based systems. Complex metabolites, particularly polyphenols, often cause recombinant protein aggregation during purification.
Hai‐Ping Diao, Hui‐Xin Meng, Xue‐Jiao Xu, Zeng‐Lin Zhang, Jian‐Feng Zhang, Yong‐Feng Guo, Inhwan Hwang, Shi‐Jian Song   +7 more
wiley   +1 more source

Natural Flavonoids from Licorice as Potent Inhibitors of β-Glucuronidase Elucidated Through Computational Studies

Molecules
Gut bacterial β-glucuronidase is an important molecular target in several therapeutic applications. β-glucuronidase inhibitors can effectively alleviate gastrointestinal toxicity caused by certain drugs.
Jingli Liu, Yingying Xue, Hao Yan, Jing Zhou, Xu Long, Yuping Tang   +5 more
doaj   +1 more source