Results 81 to 90 of about 63,621 (270)

The Diagnostic Odyssey of a Biochemically Confirmed Case of ML II: The First Western Patient With LYSET Deficiency

Clinical Genetics, EarlyView.
We identify a female patient with a homozygous nonsense variant (p.Gln38Ter) in the LYSET gene. This is the first western report of a challenging case of an extensive diagnostic odyssey and demonstrates that the LYSET gene must be considered in the differential diagnosis when M6P‐labeled lysosomal enzymes are altered.
Fernanda Sperb‐Ludwig, Taciane Alegra, Leonardo Martinello da Rosa, Nataniel Floriano Ludwig, Renata Voltolini Velho, Ida Vanessa Doederlein Schwartz   +5 more
wiley   +1 more source

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

Impact of bidirectional relationships between streptococcus anginosus group and host tissue matrix components on cellular activity: Role in establishment of infection [PDF]

, 2003
This paper investigates pathogenic mechanisms of the Streptococcus anginosus group (SAG) of bacteria which influence the biological activity of periodontal ligament (PDL) cells, endothelial cells and also how matrix proteins produced by these host cells ...
Waddington, Rachel J., Landrygan-Bakri, Janine, Wilson, Melanie, Williams, David W., Lewis, Michael Alexander Oxenham   +4 more
core   +10 more sources

Presence of benznidazole conjugated metabolites in urine identified by β-glucuronidase treatment

Brazilian Journal of Pharmaceutical Sciences, 2020
Chagas disease is a serious public health problem in Latin America and, due to migration, in other non-endemic regions. Benznidazole (BNZ) is first choice drug in pediatric therapeutics. However, little is known regarding its metabolism in humans.
María Elena Marson, Facundo García Bournissen, Jaime Altcheh, Guillermo Moscatelli, Samantha Moroni, Guido Enrique Mastrantonio   +5 more
doaj   +1 more source

lincRNA6679 promotes FnPR1B expression via phosphorylation‐activated FnWRKY14 to enhance strawberry resistance to Botrytis cinerea

Journal of Integrative Plant Biology, EarlyView.
In strawberry, Botrytis cinerea induces the expression of the long, intergenic non‐coding RNA lincRNA667，which upregulates the transcription factor gene FnWRKY14. FnWRKY14 then binds to the promoter of the pathogenesis‐related gene FnPR1B, enhancing strawberry resistance to B. cinerea.
Yuhan Guan, Zhuo Zhang, Zihui Zhang, Yan Wang, Wei Guo, Zhihong Zhang, He Li   +6 more
wiley   +1 more source

Determination of Rottlerin, a Natural Protein Kinases C Inhibitor, in Pancreatic Cancer Cells and Mouse Xenografts by RP-HPLC Method. [PDF]

, 2013
Rottlerin is a natural polyphenolic ketone isolated from the pericarps of Mallotus phillippinensis. In previous studies we showed that parenteral administration of rottlerin reduced tumor growth in murine xenograft models of pancreatic cancer. The aim of
Edderkaoui, Mouad, Eibl, Guido, Go, Vay-Liang, Lu, Qing-Yi, Lugea, Aurelia, Moro, Aune, Pandol, Stephen, Zhang, Lifeng   +7 more
core   +1 more source

Premières observations sur les activités enzymatiques developpées dans le moût de raisins par certains champignons filamenteux

OENO One, 1986
La composition macromoléculaire des extraits alcooliques de moûts parasités par certains champignons filamenteux est variable, également certaines activités enzymatiques qui leur sont associées. Tandis que l'extrait de Botrytis cinerea se caractérise par
Maria Vitória San Romão, Maria Filomena Silva Alemão   +1 more
doaj   +1 more source

OsCPN10a, cooperating with OsCPN20 and OsHSP60‐3B negatively regulate ABA signaling and enhance seed storability in rice

Journal of Integrative Plant Biology, EarlyView.
Abscisic acid signaling homeostasis is essential for seed storability. The molecular chaperone OsCPN10a enhances rice seed storability by forming a trimeric chaperone complex with OsCPN20‐OsHSP60‐3B that attenuates abscisic acid signaling via direct interaction with OsPYL10‐OsABIL1, thereby maintaining starch integrity and offering a promising target ...
Sufeng Liao, Yidong Wei, Yongsheng Zhu, Kunyang Li, Ting Chen, Shuai Zhao, Fangxi Wu, Jinlan Wang, Pengbo Yu, Hongguang Xie, Liping Chen, Qiuhua Cai, Huaan Xie, Jianfu Zhang   +13 more
wiley   +1 more source

Long-Term Follow-up Posthematopoietic Stem Cell Transplantation in a Japanese Patient with Type-VII Mucopolysaccharidosis [PDF]

, 2020
The effectiveness of hematopoietic stem cell transplantation (HSCT) for type-VII mucopolysaccharidosis (MPS VII, Sly syndrome) remains controversial, although recent studies have shown that it has a clinical impact. In 1998, Yamada et al.
Fukao, Toshiyuki, Orii, Kenji, Orii, Tadao, Suzuki, Yasuyuki, Tomatsu, Shunji   +4 more
core   +1 more source

Efficient Protein Expression and Virus-Induced Gene Silencing in Plants Using a Crinivirus-Derived Vector. [PDF]

, 2018
Plant virus-based vectors are valuable tools for recombinant gene expression and functional genomics for both basic and applied research. In this study, Lettuce infectious yellows virus (LIYV) of the genus Crinivirus was engineered into a virus vector ...
Falk, Bryce W, Qiao, Wenjie
core   +3 more sources