Results 81 to 90 of about 43,079 (209)

β-Glucuronidase triggers extracellular MMAE release from an integrin-targeted conjugate [PDF]

, 2019
A non-internalizing αvβ3 integrin ligand was conjugated to the anticancer drug MMAE through a β-glucuronidase-responsive linker. In the presence of β-glucuronidase, only the conjugate bearing a PEG4 spacer inhibited the proliferation of integrin ...
Müller, Christoph, Arosio, Daniela, Hechler, Torsten, Belvisi, Laura, Dal Corso, Alberto, López Rivas, Paula, Pahl, Andreas, Breunig, Christian, Pignataro, Luca, Gennari, Cesare, Rivas Paula Lopez, Hechler Torsten, Dal Corso Alberto, Breunig Christian, Gennari Cesare, Belvisi Laura, Pignataro Luca, Pahl Andreas, Arosio Daniela, Mueller Christoph   +19 more
core   +1 more source

Knocking Out Two Polyphenol Oxidase Genes Significantly Improves Recombinant Protein Purification in Nicotiana benthamiana

Plant Biotechnology Journal, EarlyView.
ABSTRACT Efficient purification remains a key technical challenge affecting the recovery efficiency of recombinant proteins in plant‐based systems. Complex metabolites, particularly polyphenols, often cause recombinant protein aggregation during purification.
Hai‐Ping Diao, Hui‐Xin Meng, Xue‐Jiao Xu, Zeng‐Lin Zhang, Jian‐Feng Zhang, Yong‐Feng Guo, Inhwan Hwang, Shi‐Jian Song   +7 more
wiley   +1 more source

A case of mucolipidosis Ⅱalpha/beta caused by GNPTAB gene mutation and its enzyme analysis

Zhongguo linchuang yanjiu
Objective To summarize the clinical features,enzymatic and genetic diagnostic approaches in a neonatal case of mucolipidosis(ML)Ⅱα/β caused by compound heterozygous mutations in the N-acetylglucosamine - 1 -phosphatetransferase subunits alpha and beta ...
LIANG Rujia, LIU Fang, YIN Xiaowei, DU Zhifang, LIU Jun   +4 more
doaj   +1 more source

Unexpected Suppression of Tomato Fruit Cuticle Formation by Overexpression of a Key Cutin Biosynthetic Enzyme

Plant Biotechnology Journal, EarlyView.
ABSTRACT Fruit cuticles regulate the diffusion of water, gases and solutes, functioning as essential protective interfaces against environmental and biotic stresses. Engineering cuticle structure and mechanics therefore represents a promising strategy for improving fruit quality and resilience.
Gulab Chand Arya, Ekram Wassel, Vibha Mishra, Ekaterina Manasherova, Ruth E. Stark, Hagai Cohen   +5 more
wiley   +1 more source

Agrobacterium-Mediated Stable Transformation of Medicinal Plant Andrographis paniculata Callus Expressing β-glucuronidase (GUS) Gene

Indonesian Journal of Biotechnology, 2015
This study was carried out to establish a stable genetic transformation in callus culture of Andrographispaniculata mediated by Agrobacterium tumefaciens. The leaf disks of A. paniculata were infected with A.
Erly Marwani, Agustina Tangapo, Fenny Martha Dwivany   +2 more
doaj  

Molecular Insights Into β‐Glucuronidase Inhibition by Alhagi Graecorum Flavonoids: A Computational and Experimental Approach

ChemistryOpen
In this study, we aimed to investigate the inhibitory mechanisms of β‐glucuronidase by flavonoids derived from Alhagi graecorum through both experimental and computational approaches.
Dr. Emadeldin M. Kamel, Saleh Maodaa, Esam M. Al‐Shaebi, Al Mokhtar Lamsabhi   +3 more
doaj   +1 more source

Indole bearing thiadiazole analogs: synthesis, β-glucuronidase inhibition and molecular docking study

BMC Chemistry, 2019
Background Indole based thiadiazole derivatives (1–22) have synthesized, characterized by NMR and HREI-MS and evaluated for β-Glucuronidase inhibition. All compounds showed outstanding β-glucuronidase activity with IC50 values ranging between 0.5 ± 0.08 ...
Noor Barak Almandil, Muhammad Taha, Mohammed Gollapalli, Fazal Rahim, Mohamed Ibrahim, Ashik Mosaddik, El Hassane Anouar   +6 more
doaj   +1 more source

A MYB‐Related Transcriptional Module Cooperatively Represses Xylem Development in Poplar

Plant Biotechnology Journal, EarlyView.
ABSTRACT MYB transcription factors play crucial roles in regulating plant growth and development, but the functions of the MYB‐related subfamily in woody plants remain poorly understood. In this study, we characterized PagMYBR028, an MYB‐related transcription factor from poplar ‘84 K’ (Populus alba × Populus glandulosa), which was predominantly ...
Gaofeng Fan, Jiahui Jiang, Zihan Cheng, Feixiang Ma, Zhanling Sun, Zelin Li, Yu Qi, Guanzheng Qu, Tingbo Jiang   +8 more
wiley   +1 more source

Weak androgen reduces the rate constant of beta-glucuronidase induction.

, 1985
Administration of androgen to mice induces kidney beta-glucuronidase. Measuring beta-glucuronidase activity, rate of beta-glucuronidase synthesis, beta-glucuronidase mRNA activity and beta-glucuronidase mRNA concentration, the time course of induction
Paigen, K, Watson, G, Bullock, L P
core   +1 more source

Evaluation of the gut microbiome and sex hormones in postmenopausal women with newly diagnosed hormone receptor-positive breast cancer versus healthy women: a prospective case-control study

Journal of Cancer Research and Clinical Oncology
Purpose The functional composition and diversity of the gut microbiome may affect breast cancer risk by modulation of systemic sex hormones. Gut bacteria with β-glucuronidase enzymatic activity may deconjugate estrogens, leading to increased estrogen ...
Maryann Kwa, Grant Hussey, Yelena Novik, Adrian A. Franke, Angelina Volkova, Karina Flores, Martin J. Blaser, James Speyer, Ruth Oratz, Marleen Meyers, Komal Jhaveri, Ezeddin Fadel, Adriana Heguy, Jonas Schluter, Kelly V. Ruggles, Sylvia Adams   +15 more
doaj   +1 more source